Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells

Autor: Meneses-Salas E., García-Melero A., Kanerva K., Blanco-Muñoz P., Morales-Paytuvi F., Bonjoch J., Casas J., Egert A., Beevi S.S., Jose J., Llorente-Cortés V., Rye K.-A., Heeren J., Lu A., Pol A., Tebar F., Ikonen E., Grewal T., Enrich C., Rentero C.

Publikováno v: CELLULAR AND MOLECULAR LIFE SCIENCES
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6) overexpression induces a phenotype reminiscent of NPC1 mutant cells. Here, we demonstrate that this cellula

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