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Autor: Andrea Floris, Jia Luo, Jacqueline Frank, Jennifer Zhou, Sandro Orrù, Michela Biancolella, Sabina Pucci, Augusto Orlandi, Paolo Campagna, Antonella Balzano, Komal Ramani, Maria Lauda Tomasi

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-16 (2019)

Abstract Background Ethanol abuse promotes breast cancer development, metastasis and recurrence stimulating mammary tumorigenesis by mechanisms that remain unclear. Normally, 35% of breast cancer is Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2)-positive

Externí odkaz: https://doaj.org/article/71eae85f475d48e09c0f13374dfee2fd

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Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

Autor: Inês Cebola, Michele Solimena, Mickaël Canouil, Paul Gadue, Guy A. Rutter, Sameena Nawaz, Piero Marchetti, Leonardo Alemeida-Souza, Amna Khamis, Anke M. Schulte, Harvey T. McMahon, Gaelle Carrat, Benoit Hastoy, Shuying Jiang, Ming Hu, Fabian L. Cardenas-Diaz, Philippe Froguel, Mark Ibberson

Publikováno v: Cell Reports
Cell Rep. 34:108703 (2021)

Summary Using chromatin conformation capture, we show that an enhancer cluster in the STARD10 type 2 diabetes (T2D) locus forms a defined 3-dimensional (3D) chromatin domain. A 4.1-kb region within this locus, carrying 5 T2D-associated variants, phys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427694070cd0fe6438ee0cd5d923e073
http://europepmc.org/articles/PMC7972990

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The Mechanisms of miR-638/StarD10 in HDL Metabolism

Autor: Ping Ye, Xiaona Wang, Yongyi Bai, Jie Han, Ruihua Cao

Background: MicroRNA (miRNA) plays an important role in regulation of genes, especially in post-transcriptional level. Many studies had studied the role of miRNAs in the development and progression of cardiovascular disease through miRNA knockout mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc00efb5891b4db0b5af2133e754151a
https://doi.org/10.21203/rs.3.rs-142814/v1

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The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

Publikováno v: Molecular Metabolism
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
bioRxiv
Molecular metabolism, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
Molecular Metabolism, Vol 40, Iss, Pp 101015-(2020)
Carrat, G, Haythorne, E, Tomas, A, Haataja, L, Muller, A, Arvan, P, Piunti, A, Cheng, K, Huang, M, Pullen, T J, Georgiadou, E, Stylianides, T, Amirruddin, N S, Salem, V, Distaso, W, Cakebread, A, Heesom, K J, Lewis, P A, Hodson, D J, Briant, L J B, Fung, A, Sessions, R B, Alpy, F, Kong, A, Benke, P, Torta, F, Keong Teo, A K, Leclerc, I, Solimena, M, Wigley, DB & Rutter, G A 2020, ' The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis ', Molecular metabolism, vol. 40, 101015 . https://doi.org/10.1016/j.molmet.2020.101015

Objective Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee31ae299bb38311feeaf4ba6eff987
http://hdl.handle.net/10044/1/80098

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