An image-based high-content screening for compounds targeting Toxoplasma gondii repurposed inhibitors effective against the malaria parasite Plasmodium falciparum

Autor: Ariane Honfozo, Rodrigue Houngue, Alexandre Vandeputte, Sébastien Dechavanne, Odilon Nouatin, Ménonvè Cynthia Atindehou, Lucie Ayi Fanou, Achille Massougbodji, Célia Dechavanne, Priscille Brodin, Stanislas Tomavo

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Apicomplexa phylum includes numerous obligate intracellular protozoan parasites that are life threatening for humans and animals. In this context, Plasmodium falciparum and Toxoplasma gondii are of particular interest, as they are responsible for mal

Externí odkaz: https://doaj.org/article/bbfbd6f7a41c49198d57b569c3e4c37f

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Autor: Christophe J. Queval, Ok-Ryul Song, Jean-Philippe Carralot, Jean-Michel Saliou, Antonino Bongiovanni, Gaspard Deloison, Nathalie Deboosère, Samuel Jouny, Raffaella Iantomasi, Vincent Delorme, Anne-Sophie Debrie, Sei-Jin Park, Joana Costa Gouveia, Stanislas Tomavo, Roland Brosch, Akihiko Yoshimura, Edouard Yeramian, Priscille Brodin

Publikováno v: Cell Reports, Vol 20, Iss 13, Pp 3188-3198 (2017)

Pathogens have evolved a range of mechanisms to counteract host defenses, notably to survive harsh acidic conditions in phagosomes. In the case of Mycobacterium tuberculosis, it has been shown that regulation of phagosome acidification could be achie

Externí odkaz: https://doaj.org/article/c60ab7168e7d4646a016b88a181239ea

Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection

Autor: Lamba Omar Sangaré, Tchilabalo Dilezitoko Alayi, Benoit Westermann, Agnes Hovasse, Fabien Sindikubwabo, Isabelle Callebaut, Elisabeth Werkmeister, Frank Lafont, Christian Slomianny, Mohamed-Ali Hakimi, Alain Van Dorsselaer, Christine Schaeffer-Reiss, Stanislas Tomavo

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

The retromer complex is a multi-protein component of the endosomal protein sorting machinery. Here, Sangaré et al. identify unique features in the retromer complex of the parasite Toxoplasma gondii, and show that it is crucial for the biogenesis of

Externí odkaz: https://doaj.org/article/2b4b0e9f9cbe44d0921cbc4be51f84a4

The luminal domain of Toxoplasma gondii sortilin adopts a ring-shaped structure exhibiting motifs specific to apicomplexan parasites

Autor: Ariane Honfozo, Rania Ghouil, Tchilabalo Dilezitoko Alayi, Malika Ouldali, Ana-Andreea Arteni, Cynthia Menonve Atindehou, Lucie Ayi Fanou, Yetrib Hathout, Sophie Zinn-Justin, Stanislas Tomavo

Publikováno v: Frontiers in Parasitology. 2

Rhoptries and micronemes are essential for host cell invasion and survival of all apicomplexan parasites, which are composed of numerous obligate intracellular protozoan pathogens including Plasmodium falciparum (malaria) and Toxoplasma gondii (toxop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0d06cb0030c70d96063906412d7ace7
https://doi.org/10.3389/fpara.2023.1103772

A noncanonical autophagy is involved in the transfer of Plasmodium -microvesicles to astrocytes

Autor: Sophie Salomé Desnoulez, Priscille Brodin, Sylviane Pied, Nasreddine Saidi, Frank Lafont, Inès Leleu, Stanislas Tomavo, Delphine Genete

Publikováno v: Autophagy
Autophagy, Taylor & Francis, 2021, pp.1-16. ⟨10.1080/15548627.2021.1993704⟩
Autophagy, 2022, 18 (7), pp.1583-1598. ⟨10.1080/15548627.2021.1993704⟩

International audience; Cerebral malaria is a neuroinflammatory disease induced by P. falciparum infection. In animal models, the neuro-pathophysiology of cerebral malaria results from the sequestration of infected red blood cells (iRBCs) in microves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b953a4f7491e06b8cdae31c28b230127
https://hal.archives-ouvertes.fr/hal-03457297