Zobrazeno 1 - 10
of 41
pro vyhledávání: '"SS-68"'
Autor:
Anatoliy A. Nechepurenko, Pavel A. Galenko-Yaroshevsky, Vladimir M. Pokrovskiy, Anait V. Zelenskaya, Konstantin F. Suzdalev, Svetlana A. Lebedeva, Natalia M. Makhnova, Alexandr V. Maksemyuk, Ivan A. Minenko, Roman V. Nikitin, Valeriy G. Abushkevich
Publikováno v:
Research Results in Pharmacology, Vol 9, Iss 4, Pp 31-41 (2023)
Introduction: Atrial fibrillation (AF) is the most common form of cardiac arrhythmias. Studying the pathogenesis of this pathological process will make it possible to look for new methods of treating AF and to predict its occurrence in a more targete
Externí odkaz:
https://doaj.org/article/b9a34f56e99a4ea9bb2a2582dd415fc8
Publikováno v:
Кубанский научный медицинский вестник, Iss 6, Pp 62-66 (2016)
In the experiments on isolated circular segments of the thoracic aorta of a rat it has been proved that indole SS-66 derivative in 10-5 and 10-4 М concentrations can relax smooth muscle cells (SMS) due to its impact on the SMS potassium conduction t
Externí odkaz:
https://doaj.org/article/30878575d2d048c08f13e4722248434e
Autor:
I. L. Cherednik, S. . K Bogus, K. F. Suzdalev, P. A. Galenko-Yaroshevsky, P. G. Storozhuk, V. G. Abushkevich, A. A. Kashkaryan, B. S. Babayan, A. I. Trofimenko
Publikováno v:
Кубанский научный медицинский вестник, Iss 6, Pp 135-139 (2016)
In experiments on anaesthetized cats in the sinoatrial node (SAN), located in induced high-frequency electric field, focus glow (FG) is visualized, which upon stimulation of the vagus nerve (VN) by periodic electrical impulses undergoes significant c
Externí odkaz:
https://doaj.org/article/ebf4124fbc884d258257d48a7a97225b
Publikováno v:
Кубанский научный медицинский вестник, Iss 5, Pp 11-14 (2016)
It was presented that the indole SS-68 derivative (10-6 and 10-5 М) revealed the manifested antianginal action as well as the antiarrhythmic one in experiments on rats' isolated heart, at the same time it had no considerable influence on the contrac
Externí odkaz:
https://doaj.org/article/754d3589d67b4a6b9ab0b7ee896fe149
Autor:
Saida Bogus, Konstantin Suzdalev, Aleksandr Uvarov, Pavel Galenko-Yaroshevsky, Pavel M., Dmitry Vinakov, Natalia Kiseleva, A.N. Kochetkov, A.V. Kiselev
Publikováno v:
Research Results in Pharmacology, Vol 3, Iss 4, Pp 26-34 (2017)
The experiments with rats show that when administered intravenously (5 mg/kg) and intragastrically (5, 10, 15 and 20 mg/kg), SS-68 compound exerts an anti-inflammatory effect (AIE) on models of acute inflammation, caused by carrageenin and serotonin,
Externí odkaz:
https://doaj.org/article/0d0bda835ce74201a1c39edbda1e180a
Publikováno v:
Кубанский научный медицинский вестник, Vol 0, Iss 3, Pp 17-21 (2017)
Aim. Study of SS-68 impact on primary generalized convulsions in basic estimation tests of anticonvulsant action of agents.Material and methods. Study of the SS-68 impact on primary generalized convulsions included an estimation of anticonvulsant act
Externí odkaz:
https://doaj.org/article/3bc27f13a8334a06a12b2903394c3406
Autor:
Saida Bogus, Aleksandr Dukhanin, Aida Kucheryavenko, Dmitry Vinakov, Konstantin Suzdalev, Pavel Galenko-Yaroshevsky
Publikováno v:
Research Results in Pharmacology, Vol 3, Iss 2, Pp 3-13 (2017)
Background: A new indole derivative with the lab code-number SS-68 demonstrates a significant antiarrhythmic (anti-fibrillation) activity associated with the predominant influence on potassium and calcium conductivity of cardiomyocytes plasmalemmas.
Externí odkaz:
https://doaj.org/article/6e2e6bbc50f64b359a1de8ce8210ee73
Publikováno v:
Кубанский научный медицинский вестник, Vol 1, Iss 2, Pp 24-29 (2017)
The influence of compound SS-68, known for its marked antiarrhythmic properties, on the intension of electrophysiological effects of α1- и β- adrenoreceptors stimulation was studied in right atrial preparations from rat. Activation of α1-adrenore
Externí odkaz:
https://doaj.org/article/98664bcf66f54648b9af73ceb50b8718
Publikováno v:
Кубанский научный медицинский вестник, Iss 3, Pp 150-153 (2015)
The substance SS-68 relaxes smooth muscles cells of tracheal rings of guinea pig in vitro. Such effect is selective for β2-adrenergic receptors, and type of this influence depends on method of stimulation on insulated trachea. The duration of effect
Externí odkaz:
https://doaj.org/article/fec2053b2cc5449f9fda38e617936996
Autor:
Pavel Galenko-Yaroshevsky, Alexandr Kulikov, Dmitry Vinakov, Tatyana Avtina, Konstantin Suzdalev, Mikhail Pokrovskii
Publikováno v:
Research Results in Pharmacology, Vol 2, Iss 2, Pp 20-24 (2016)
A method of quantitative determination of SS-68 derivative of indole in rabbit blood plasma by high performance liquid chromatography with tandem mass spectrometric detector (HPLCMS/MS). Conducted pharmacokinetic studies SS-68 in the body of rabbits.
Externí odkaz:
https://doaj.org/article/d30b2ec35e1a45c6af73108e854473df