Abstract P4-14-08: Serum concentrations of tamoxifen and Z-endoxifen may predict sexual dysfunction in the 2nd year of adjuvant endocrine treatment

Autor: Gunnar Mellgren, Ea Lien, S Lunde, E Bifulco, BH Gripsrud, K Lode, RA Lind, SS Hustad, J Jonassen, Håvard Søiland, JT Kvaløy, NS Gebreslase, ME Haugstøyl, Emiel A. M. Janssen, Tone Hoel Lende, Turid Aas, Thomas Helland, KB Hagen

Publikováno v: Cancer Research. 79:P4-14

Background and rationale: Side effects of adjuvant treatment with tamoxifen (tam) may impair Quality of Life (QoL) and have been suggested as an independent variable for discontinuation of tam1. There are large inter-patient variabilities in prevalen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::525bd65f1703d45a6b3747889acecb9a
https://doi.org/10.1158/1538-7445.sabcs18-p4-14-08

Abstract P2-09-11: Metabolite-guided long-term prediction of outcome in tamoxifen treated breast cancer patients

Autor: SS Hustad, Gunnar Mellgren, Vessela N. Kristensen, Timothy L. Lash, Bjørn Naume, Elin Borgen, Eam Janssen, N Henne, Håvard Søiland, Ea Lien, E Bifulco, Thomas Helland

Publikováno v: Cancer Research. 77:P2-09

Background The genetic polymorphisms of CYP2D6 determine its enzymatic activity thereby the pharmacokinetic velocity by which tamoxifen (tam) is converted into active metabolites. Combined analyses of tam metabolites compared to CYP2D6 type and long-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca7cf6605c9eff31ad916c683c6185c
https://doi.org/10.1158/1538-7445.sabcs16-p2-09-11

Presurgical Oral Tamoxifen vs Transdermal 4-Hydroxytamoxifen in Women With Ductal Carcinoma In Situ: A Randomized Clinical Trial.

Autor: Khan SA; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Mi X; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Xu Y; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Blanco LZ Jr; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Akasha AM; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Pilewskie M; Department of Surgery, University of Michigan, Ann Arbor., Degnim AC; Department of Surgery, Mayo Clinic, Rochester, Minnesota., AlHilli Z; Department of Surgery, Cleveland Clinic, Cleveland, Ohio., Amin AL; Department of Surgery, University Hospitals, Cleveland, Ohio., Hwang ES; Department of Surgery, Duke University Medical Center, Durham, North Carolina., Guenther JM; Deparmtent of Surgery, St Elizabeth Healthcare, Edgewood, Kentucky., Kocherginsky M; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Benante K; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Zhang S; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Helland T; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Hustad SS; Department of Clinical Science, University of Bergen, Bergen, Norway., Gursel DB; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Mellgren G; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Dimond E; Division of Cancer Prevention, National Cancer Institute Bethesda, Maryland., Perloff M; Division of Cancer Prevention, National Cancer Institute Bethesda, Maryland., Heckman-Stoddard BM; Division of Cancer Prevention, National Cancer Institute Bethesda, Maryland., Lee O; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Publikováno v: JAMA surgery [JAMA Surg] 2023 Dec 01; Vol. 158 (12), pp. 1265-1273.