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Akademický článek

SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease

Autor: Chih-Chang Chao, Chuen-Lin Huang, Jing-Jy Cheng, Chun-Tang Chiou, I-Jung Lee, Ying-Chen Yang, Ting-Huang Hsu, Chia-En Yei, Pei-Ying Lin, Jih-Jung Chen, Nai-Kuei Huang

Publikováno v: Redox Biology, Vol 58, Iss , Pp 102534- (2022)

Epidemiological studies have linked herbicides and Parkinson's disease (PD), with the strongest associations resulting from long exposure durations. Paraquat (PQ), an herbicide, induces PD-like syndromes and has widely been accepted as a PD mimetic.

Externí odkaz: https://doaj.org/article/a5bd6a275cd94268b734a16789761737

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Akademický článek

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Akademický článek

SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485

Autor: Jin Young Sung, Seul Gi Kim, Du Hyong Cho, Jae‐Ryong Kim, Hyoung Chul Choi

Publikováno v: FEBS Open Bio, Vol 10, Iss 7, Pp 1316-1325 (2020)

Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported

Externí odkaz: https://doaj.org/article/e884b1e35a0045f3808f314f1ffac48d

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Akademický článek

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Akademický článek

Resveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1

Autor: Shuang Guo, Hongyan Liao, Jie Liu, Jing Liu, Fanren Tang, Zhongxiang He, Yangchun Li, Qin Yang

Publikováno v: Cellular Physiology and Biochemistry, Vol 50, Iss 4, Pp 1346-1360 (2018)

Background/Aims: Injuries of the brain and spinal cord result in the formation of glial (reactive gliosis) and fibrotic (formed by fibroblasts) scars. Recent studies have shown that the fibrotic scar was much more important for hindering regeneration

Externí odkaz: https://doaj.org/article/fc0cdb81fa134f1da18e544987ac7242

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Akademický článek

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

Autor: Sung-Jun Park, Faiyaz Ahmad, Jee-Hyun Um, Alexandra L. Brown, Xihui Xu, Hyeog Kang, Hengming Ke, Xuesong Feng, James Ryall, Andrew Philp, Simon Schenk, Myung K. Kim, Vittorio Sartorelli, Jay H. Chung

Publikováno v: EBioMedicine, Vol 18, Iss C, Pp 128-138 (2017)

The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle, presumably by activating Sirt1. However, Sirt1 gain of function does not increase mitochondrial function, which raises a question about the central role of Sirt

Externí odkaz: https://doaj.org/article/2b73554243de45c48ea76253461f6cbd

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Akademický článek

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Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts

Autor: Lan Guo, Yaser Almatari, Yu Wang, Penghao Wang, Runhong Mei, Peng Luo, Lei Guo, Shimin Hao

Publikováno v: Aging (Albany NY)

Osteoporosis is a common systemic skeletal metabolism disorder resulting in bone fragility and increased fracture risk. Silent information regulator factor 2 homolog 1 (SIRT1) is crucial in the regulation of several biological processes, including bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44de881dc865ef72b7cdecfa31a684b7
https://doi.org/10.18632/aging.203639

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SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis

Autor: Qiang Wei, Peng Zhang, Chong Chen, Jiapeng Zhang, Tianhai Lin, Ping Han, Lu Qi, Lu Yang, Ping Tan, Jiajia Du, Ailing Zhong, Yiyun Wang, Jingyao Chen, Yu Liu, Manli Wang, Jian Wang, Zhanying Bi, Qiyong Gong

Publikováno v: Oncogene. 40:6081-6092

There are unmet clinical needs for novel therapeutic targets and drugs for bladder cancer. Majority of previous work relied on limited bladder cancer cell lines, which could not well represent the tumor heterogeneity and pathology of this disease. Re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe5d2b870b4a203ab162714ee2a0b6
https://doi.org/10.1038/s41388-021-01999-9

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Effect and mechanism of Angelic Shaoyaosan mediated AMPK/SIRT1 positive feedback loop to promote autophagy and regulate the systemic inflammatory response in acute pancreatitis

Autor: Peijun Sun, Miao Nie

Publikováno v: Cellular and Molecular Biology. 67:101-108

This research was carried out to investigate the effect and mechanism of Angelic Shaoyaosan mediated AMPK/SIRT1 positive feedback loop to promote autophagy and regulate systemic inflammatory response in acute pancreatitis. In this study, the rat panc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfad59057e7cc348105c1661f1651b5b
https://doi.org/10.14715/cmb/2021.67.2.15

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