Zobrazeno 1 - 10
of 504
pro vyhledávání: '"SREBPs"'
Autor:
Siyuan Liu, Xinzhu Li, Panpan Fan, Yujia Gu, Aizhu Yang, Weiyi Wang, Lijun Zhou, Huanhua Chen, Fangyuan Zheng, Junjie Lin, Zihua Xu, Qingchun Zhao
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117575- (2024)
Sterol regulatory element binding proteins (SREBPs) are a series of cholesterol-related transcription factors. Their role in regulating brain cholesterol biosynthesis, amyloid accumulation, and tau tangles formation has been intensively studied in pr
Externí odkaz:
https://doaj.org/article/5bdceb8aaeab4d75820bf7c6a86e2a76
Publikováno v:
Translational Oncology, Vol 44, Iss , Pp 101925- (2024)
Background/Aims: Prostate cancer is the most frequently diagnosed cancer among men in the United States and is the second leading cause of cancer-related deaths in men. The incidence of prostate cancer is gradually rising due to factors such as aging
Externí odkaz:
https://doaj.org/article/fe863165ae344813a2f888cf92d67210
Publikováno v:
Heliyon, Vol 10, Iss 8, Pp e29367- (2024)
The prevalence of obesity and its primary associated comorbidities, such as type 2 diabetes and fatty liver disease, has reached epidemic proportions, with no successful treatment available at present. Heat shock protein 90 (HSP90), a crucial chapero
Externí odkaz:
https://doaj.org/article/fcdfc274a08948dfaf14bff3d051b163
Autor:
Tianqi Cai, Xiaoxue Xu, Ling Dong, Shufei Liang, Meiling Xin, Tianqi Wang, Tianxing Li, Xudong Wang, Weilong Zheng, Chao Wang, Zhengbao Xu, Meng Wang, Xinhua Song, Lingru Li, Jingda Li, Wenlong Sun
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e29168- (2024)
Background: Lipid metabolism disorders have become a major global public health issue. Due to the complexity of these diseases, additional research and drugs are needed. Oroxin A, the major component of Oroxylum indicum (L.) Kurz (Bignoniaceae), can
Externí odkaz:
https://doaj.org/article/4bab525183424b5387ab484cfbcf8c44
Akademický článek
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Publikováno v:
Ecotoxicology and Environmental Safety, Vol 271, Iss , Pp 116010- (2024)
Tri-ortho-cresyl phosphate (TOCP), an organophosphorus compound (OP), which is widely used as plasticizer, flame retardant and other industrial products, has been reported to cause multiple toxicities including neurotoxicity and reproductive toxicity
Externí odkaz:
https://doaj.org/article/06c305b4c9cf46eaa6b9f6e08db2999b
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
The phenomenon of polypharmacy is a common occurrence among older people with multiple health conditions due to the rapid increase in population aging and the popularization of clinical guidelines. The prevalence of metabolic syndrome is growing quic
Externí odkaz:
https://doaj.org/article/fd862cd898a64395a2633b85cfa83962
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 1, Pp 100472- (2024)
Liver steatosis is a common metabolic disorder resulting from imbalanced lipid metabolism, which involves various processes such as de novo lipogenesis, fatty acid uptake, fatty acid oxidation, and VLDL secretion. In this study, we discovered that KL
Externí odkaz:
https://doaj.org/article/9066ce0e78ad41ee98a5c0b279fdb2c9
Autor:
Qingsong Xia, Fuer Lu, Yu Chen, Jingbin Li, Zhaoyi Huang, Ke Fang, Meilin Hu, Yujin Guo, Hui Dong, Lijun Xu, Jing Gong
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116060- (2024)
Excessive synthesis of triglycerides and cholesterol accelerates the progression of hepatic steatosis in metabolic-associated fatty liver disease (MAFLD). However, the precise mechanism by which 6-gingerol mitigates hepatic steatosis in MAFLD model m
Externí odkaz:
https://doaj.org/article/b387effc22304be49c6b34a4a5639989
Autor:
Shan Shen, Mingyang Shen, Lirun Kuang, Keyu Yang, Shiran Wu, Xinde Liu, Yuting Wang, Yong Wang
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107037- (2024)
Sirtuins, also called silent information regulator 2, are enzymes that rely on nicotinamide adenine dinucleotide (NAD+) to function as histone deacetylases. Further investigation is warranted to explore the advantageous impacts of Sirtuin 1 (SIRT1),
Externí odkaz:
https://doaj.org/article/ff1bf81ed87647b4930206c54df147ca