Zobrazeno 1 - 10
of 55
pro vyhledávání: '"SQSTM1, sequestosome 1"'
Autor:
Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58c0ac6db641c550d04c5a5c6ba5a1a
https://doi.org/10.1016/j.apsb.2021.07.021
https://doi.org/10.1016/j.apsb.2021.07.021
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the neurotrophic receptor tyrosine kinase 1, 2 and 3 (NTRK1, NTRK2 and NTRK3) genes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c737a8f0c0bb6776695689290564cb8a
http://www.sciencedirect.com/science/article/pii/S2211383520305864
http://www.sciencedirect.com/science/article/pii/S2211383520305864
Publikováno v:
Chinese Journal of Traumatology
Chinese Journal of Traumatology, Vol 25, Iss 1, Pp 1-10 (2022)
Chinese Journal of Traumatology, Vol 25, Iss 1, Pp 1-10 (2022)
Sepsis is a life-threatening clinical syndrome and one of the most challenging health problems in the world. Pathologically, sepsis and septic shock are caused by a dysregulated host immune response to infection, which can eventually lead to multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f78f03c1ea030072286a73467e72f2
https://pubmed.ncbi.nlm.nih.gov/34334261
https://pubmed.ncbi.nlm.nih.gov/34334261
Autor:
Mengru Liu, Shijia Ma, Yue Li, Anil Ahsan, Wenping Yan, Yanrong Zheng, Zhong Chen, Zhanxun Wu, Ming Cao, Xingxian Zhang, Weiwei Hu, Ling Pan, Xiangnan Zhang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1708-1720 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1708-1720 (2021)
Stroke is considered a leading cause of mortality and neurological disability, which puts a huge burden on individuals and the community. To date, effective therapy for stroke has been limited by its complex pathological mechanisms. Autophagy refers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8275a01a7067dd1af9480fcfa0d27454
https://pubmed.ncbi.nlm.nih.gov/34386317
https://pubmed.ncbi.nlm.nih.gov/34386317
Autor:
Keke Wang, Yaxin Chen, Yang Zhou, Rui Wang, Tao Li, Rong Hu, Mengran Cao, Mengdi Yang, Yunjiang Zhou
Publikováno v:
Redox Biology, Vol 29, Iss, Pp-(2020)
Redox Biology
Redox Biology
The human HEAT repeat-containing protein 1 (HEATR1), consisting of 2144 amino acids, is a member of the UTP10 family and contains one HEAT repeat at its C-terminal. HEATR1 has been reported to regulate cytotoxic T lymphocytes and rRNA synthesis, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e05750c9088c8fa20275c4fdf10c40
http://www.sciencedirect.com/science/article/pii/S2213231719309498
http://www.sciencedirect.com/science/article/pii/S2213231719309498
Autor:
Simon Wilkinson
Publikováno v:
Wilkinson, S 2019, ' Emerging Principles of Selective ER Autophagy ', Journal of Molecular Biology . https://doi.org/10.1016/j.jmb.2019.05.012
Journal of Molecular Biology
Journal of Molecular Biology
The endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and signal transduction. It is subject to complex, dynamic sculpting of morphology and composition. Degradation of ER content has an important role to play here. Indeed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246a9d79f96cd380e5927a63fe262605
https://hdl.handle.net/20.500.11820/5820d1dc-24f7-48aa-abb5-a702fa981686
https://hdl.handle.net/20.500.11820/5820d1dc-24f7-48aa-abb5-a702fa981686
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 6, Iss 1, Pp 20-25 (2016)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Diabetes mellitus (DM), an endocrine disorder, will be one of the leading causes of death world-wide in about two decades. Cellular injuries and disorders of energy metabolism are two key factors in the pathogenesis of diabetes, which also become the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4d9dc00da25955adbe0a16dee124b0
http://www.sciencedirect.com/science/article/pii/S2211383515001173
http://www.sciencedirect.com/science/article/pii/S2211383515001173
Publikováno v:
Environment International, Vol 143, Iss, Pp 105949-(2020)
Environment International
Environment International
Graphical abstract
Highlights • DON promotes PEDV entry and replication, and aggravates gut barrier injury. • CRISPR‐Cas9‐mediated LC3B knockout indicated a role of autophagy in the promotion. • p38 activation was required for the DON-
Highlights • DON promotes PEDV entry and replication, and aggravates gut barrier injury. • CRISPR‐Cas9‐mediated LC3B knockout indicated a role of autophagy in the promotion. • p38 activation was required for the DON-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae07793b5f6c7efae1198ecd91e1fd27
https://doi.org/10.1016/j.envint.2020.105949
https://doi.org/10.1016/j.envint.2020.105949
Publikováno v:
Redox Biology
Redox Biology, Vol 18, Iss, Pp 138-157 (2018)
Redox Biology, Vol 18, Iss, Pp 138-157 (2018)
Oxidative stress has been described as a prime driver of granulosa cell (GCs) death during follicular atresia. Increasing evidence suggests potential roles of melatonin in protecting GCs from oxidative injury, though the underlying mechanisms remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43adc123d49df06a5bbff4b86e0bd404
https://pubmed.ncbi.nlm.nih.gov/30014903
https://pubmed.ncbi.nlm.nih.gov/30014903
Autor:
Wenya, Ma, Fengzhi, Ding, Xiuxiu, Wang, Qi, Huang, Lai, Zhang, Chongwei, Bi, Bingjie, Hua, Ye, Yuan, Zhenbo, Han, Mengyu, Jin, Tianyi, Liu, Ying, Yu, Benzhi, Cai, Zhimin, Du
Publikováno v:
EBioMedicine
Therapeutic efficiency of cardiac progenitor cells (CPCs) transplantation is limited by its low survival and retention in infarcted myocardium. Autophagy plays a critical role in regulating cell death and apoptosis, but the role of microRNAs (miRNAs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a531176ef076856323d8e95c94729af8
https://pubmed.ncbi.nlm.nih.gov/29858017
https://pubmed.ncbi.nlm.nih.gov/29858017