Výsledky vyhledávání - "SPONTANEOUSLY HYPERTENSIVE-RAT"

Akademický článek

Potential blood pressure regulatory effect of low molecular weight α-chymotrypsin extract and its peptides from Stichopus japonicus: Peptide-ACE interaction study via in silico molecular docking

Autor: Hyo-Geun Lee, D.P. Nagahawatta, N.M. Liyanage, Yu Ri Choe, Jae-Young Oh, Won-Kyo Jung, Si-Hyeong Park, You-Jin Jeon, Hyun-Soo Kim

Publikováno v: Journal of Functional Foods, Vol 123, Iss , Pp 106551- (2024)

Hypertension is a significant risk factor for cardiovascular disease and heart damage. Stichopus japonicus (S. japonicus) is a red sea cucumber with antioxidant and anti-hypertensive activities. However, its anti-hypertensive mechanism remains unclea

Externí odkaz: https://doaj.org/article/76317cd147ed43d5bdea5ba716211f40

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Akademický článek

Investigation of the regulatory effect of α-chymotrypsin-assisted hydrolysate from Sebastes schlegelii on blood pressure through in vitro, in silico ACE inhibitory activity, and in vivo spontaneously hypertensive rat hypertensive model

Autor: Jun-Geon Je, Jaehak Sim, Hyo-Geun Lee, Chan-Young Kim, Yujin Roh, Yu Ri Choe, Si-Hyeong Park, Soo-Jin Heo, Won-Kyo Jung, You-Jin Jeon, Hyun-Soo Kim

Publikováno v: Journal of Functional Foods, Vol 121, Iss , Pp 106431- (2024)

This study aimed to screen peptides with antihypertensive effects from the α-chymotrypsin hydrolysate of Sebastes schlegelii (SSA). SSA demonstrated ACE inhibitory activity with an IC50 value of 0.062 ± 0.001 mg/mL. The SSA significantly reduced bo

Externí odkaz: https://doaj.org/article/1a03eefef5ad45fabe73ba655d8cdc41

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Akademický článek

The central mechanisms of electroacupuncture at LR3 in the treatment of spontaneous hypertension: a PET and mRNA transcriptome study

Autor: Jing Li, Chong Peng, Kejie He, Yumei Wang, Xinsheng Lai

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

ObjectiveTo reveal the efficacy and potential mechanisms of electroacupuncture (EA) in treating hypertension.MethodsMale spontaneously hypertensive rats (SHRs) were randomly assigned to the SHR group, EA group, and Sham-EA group, with Wistar-Kyoto ra

Externí odkaz: https://doaj.org/article/4c06a6f2c88442e3a7b08af0732447ca

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Akademický článek

Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats

Autor: Ivana Nemeckova, Samira Eissazadeh, Jana Urbankova Rathouska, Jan Silhavy, Hana Malinska, Michal Pravenec, Petr Nachtigal

Publikováno v: BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-9 (2024)

Abstract Background C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked with atherosclerotic disease, congestive heart failure, and ischemic hea

Externí odkaz: https://doaj.org/article/64bd60ec726e4193987ffab338abf635

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