The biological functions and related signaling pathways of SPON2

Autor: Jingrun Zhang, Ge Liu, Yuchen Liu, Pei Yang, Junyuan Xie, Xiaowei Wei

Publikováno v: Frontiers in Oncology, Vol 13 (2024)

Spondin-2 (SPON2), also referred to as M-spondin or DIL-1, is a member of the extracellular matrix protein family known as Mindin-F-spondin (FS). SPON2 can be used as a broad-spectrum tumor marker for more than a dozen tumors, mainly prostate cancer.

Externí odkaz: https://doaj.org/article/da1f580825834f6ea16c07b7425d8c47

Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC.

Autor: Huang, Chengmei^1,2,3 (AUTHOR), Ou, Ruizhang^1,2,3 (AUTHOR), Chen, Xiaoning^1,2,3 (AUTHOR), Zhang, Yaxin^1,2,3 (AUTHOR), Li, Jiexi⁴ (AUTHOR), Liang, Yihao⁵ (AUTHOR), Zhu, Xiaohui^1,2,3 (AUTHOR), Liu, Lei^1,2,3 (AUTHOR), Li, Mingzhou^1,2,3 (AUTHOR), Lin, Dagui⁶ (AUTHOR), Qiu, Junfeng^1,2,3 (AUTHOR), Liu, Guanglong^1,2,3 (AUTHOR), Zhang, Lingjie^1,2,3 (AUTHOR), Wu, Yuanyuan^1,2,3 (AUTHOR), Tang, Huiyi⁷ (AUTHOR), Liu, Yanmin⁶ (AUTHOR), Liang, Li^1,2,3 (AUTHOR), Ding, Yanqing^1,2,3 (AUTHOR) dyq@fimmu.com, Liao, Wenting^1,2,3,6 (AUTHOR) liaowt2002@gmail.com

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 9/28/2021, Vol. 40 Issue 1, p1-17. 17p.

SPON2 promotes the bone metastasis of lung adenocarcinoma via activation of the NF-κB signaling pathway

Autor: Wu, Ming, Kong, Dewei, Zhang, Yan

Publikováno v: In Bone February 2023 167

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Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC

Autor: Chengmei Huang, Ruizhang Ou, Xiaoning Chen, Yaxin Zhang, Jiexi Li, Yihao Liang, Xiaohui Zhu, Lei Liu, Mingzhou Li, Dagui Lin, Junfeng Qiu, Guanglong Liu, Lingjie Zhang, Yuanyuan Wu, Huiyi Tang, Yanmin Liu, Li Liang, Yanqing Ding, Wenting Liao

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)

Abstract Background Tumor-associated macrophages (TAMs) are key regulators of the complex interplay between cancer and the immune microenvironment. Tumor cell-derived spondin 2 (SPON2) is an extracellular matrix glycoprotein that has complicated role

Externí odkaz: https://doaj.org/article/431411549d9c4db3983cd3fcdca9e855