Zobrazeno 1 - 10
of 3 956
pro vyhledávání: '"SPINDLE-ASSEMBLY CHECKPOINT"'
Autor:
Li Sun, Xuejin Chen, Chunlin Song, Wenjing Shi, Libo Liu, Shuang Bai, Xi Wang, Jiali Chen, Chengyu Jiang, Shuang-min Wang, Zhou-qing Luo, Ruiwen Wang, Yamei Wang, Quan-wen Jin
Publikováno v:
eLife, Vol 13 (2024)
Mitotic anaphase onset is a key cellular process tightly regulated by multiple kinases. The involvement of mitogen-activated protein kinases (MAPKs) in this process has been established in Xenopus egg extracts. However, the detailed regulatory cascad
Externí odkaz:
https://doaj.org/article/8aa72e44a943468c8539d03d42d7f2de
Autor:
Alexandra N. Aquino-Acevedo, Joel A. Orengo-Orengo, Melanie E. Cruz-Robles, Harold I. Saavedra
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract This review aims to outline mitotic kinase inhibitors’ roles as potential therapeutic targets and assess their suitability as a stand-alone clinical therapy or in combination with standard treatments for advanced-stage solid tumors, includ
Externí odkaz:
https://doaj.org/article/c0344e92c24549a4a58a5e3eb44a159c
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract The spindle assembly checkpoint (SAC) ensures chromosome segregation fidelity by manipulating unattached kinetochore‐dependent assembly of the mitotic checkpoint complex (MCC). The MCC binds to and inhibits the anaphase promoting complex/c
Externí odkaz:
https://doaj.org/article/a3d7929ddeff42388b6daf2ea3db6f97
Publikováno v:
eLife, Vol 12 (2024)
The spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle. Centrosomes refine the spatial organization of the mitotic sp
Externí odkaz:
https://doaj.org/article/b767bee0b283458da048adc808a3ddf9
Autor:
Ana Belén Iglesias-Romero, Terersa Soto, Ignacio Flor-Parra, Silvia Salas-Pino, Gabriel Ruiz-Romero, Kathleen L. Gould, José Cansado, Rafael R. Daga
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into multiple adaptive responses. These responses involve transcriptional rewiring and the regulati
Externí odkaz:
https://doaj.org/article/be36313b2d3549719a218fbca1f39f4f
Autor:
Maria Kapanidou, Natalie L. Curtis, Sandra S. Diaz-Minguez, Sandra Agudo-Alvarez, Alfredo Rus Sanchez, Ammar Mayah, Rosette Agena, Paul Brennan, Paula Morales, Raul Benito-Arenas, Agatha Bastida, Victor M. Bolanos-Garcia
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1439 (2024)
Activation of the ubiquitin ligase APC/C by the protein Cdc20 is an essential requirement for proper cell division in higher organisms, including humans. APC/C is the ultimate effector of the Spindle Assembly Checkpoint (SAC), the signalling system t
Externí odkaz:
https://doaj.org/article/1a8dfceca1964136bfc4c345d6773ac1
Autor:
Lucie Crhak Khaitova, Pavlina Mikulkova, Jana Pecinkova, Manikandan Kalidass, Stefan Heckmann, Inna Lermontova, Karel Riha
Publikováno v:
eLife, Vol 12 (2024)
Heat stress is a major threat to global crop production, and understanding its impact on plant fertility is crucial for developing climate-resilient crops. Despite the known negative effects of heat stress on plant reproduction, the underlying molecu
Externí odkaz:
https://doaj.org/article/78a9f19c862349938a4572a4b6d41340
Akademický článek
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Autor:
Kang-Di Zhou, Cai-Xia Zhang, Fu-Rong Niu, Hao-Chen Bai, Dan-Dan Wu, Jia-Cheng Deng, Hong-Yuan Qian, Yun-Lei Jiang, Wei Ma
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 7974-7995 (2023)
The central player for chromosome segregation in both mitosis and meiosis is the macromolecular kinetochore structure, which is assembled by >100 structural and regulatory proteins on centromere DNA. Kinetochores play a crucial role in cell division
Externí odkaz:
https://doaj.org/article/1cf1111fb39040f99db27b477be3a814
Autor:
Jordi Bertran-Alamillo, Ana Giménez-Capitán, Ruth Román, Sara Talbot, Rebecca Whiteley, Nicolas Floc’h, Elizabeth Martínez-Pérez, Matthew J. Martin, Paul D. Smith, Ivana Sullivan, Mikkel G. Terp, Jamal Saeh, Cristina Marino-Buslje, Giulia Fabbri, Grace Guo, Man Xu, Cristian Tornador, Andrés Aguilar-Hernández, Noemí Reguart, Henrik J. Ditzel, Alejandro Martínez-Bueno, Núria Nabau-Moretó, Amaya Gascó, Rafael Rosell, J. Elizabeth Pease, Urszula M. Polanska, Jon Travers, Jelena Urosevic, Miguel A. Molina-Vila
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-24 (2023)
Abstract Background Drugs targeting the spindle assembly checkpoint (SAC), such as inhibitors of Aurora kinase B (AURKB) and dual specific protein kinase TTK, are in different stages of clinical development. However, cell response to SAC abrogation i
Externí odkaz:
https://doaj.org/article/0503e7da1cca40afa0953e96d2560af7