Zobrazeno 1 - 10
of 533
pro vyhledávání: '"SPI1"'
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-13 (2024)
Highlights SPI1 and SMAD5 are upregulated during MC3T3-E1 cell osteogenic differentiation. SPI1 enhances SMAD5 transcription. Icariin increases SMAD5 expression by upregulating SPI1. The SPI1/SMAD5 axis underlies the promoting effect of icariin on MC
Externí odkaz:
https://doaj.org/article/34bf8e3743244c78a5ffc211acc550fd
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveThis study revealed a core regulator and common upstream mechanisms for the multifaceted pathological processes of age-related macular degeneration (AMD) and provided proof-of-concept for this new therapeutic target.MethodsComprehensive gene
Externí odkaz:
https://doaj.org/article/8eadfabd31e84c48a7f42f1931eca149
Autor:
Rada Miskovic, Jelena Ljubicic, Branka Bonaci-Nikolic, Ana Petkovic, Vladana Markovic, Ivan Rankovic, Jelena Djordjevic, Ana Stankovic, Kristel Klaassen, Sonja Pavlovic, Maja Stojanovic
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPU.1-mutated agammaglobulinemia (PU.MA) represents a recently described autosomal-dominant form of agammaglobulinemia caused by mutation of the SPI1 gene. This gene codes for PU.1 pioneer transcription factor important for the maturation
Externí odkaz:
https://doaj.org/article/a0db55a5729a4b6194bf8b078893547f
Publikováno v:
Journal of Inflammation Research, Vol Volume 16, Pp 2675-2687 (2023)
Dongsheng Zhu,1,* Zhitao Zhu,2,* Han Qi3 1Department of Pediatric Surgery, the First People’s Hospital of Lianyungang, Affiliated to Xuzhou Medical University, Lianyungang, Jiangsu, 222000, People’s Republic of China; 2Department of Radio
Externí odkaz:
https://doaj.org/article/3c69c1e1ea95446080a5e4a181bac2ab
Autor:
Xiaofan Tu, Henry M. Gomez, Richard Y. Kim, Alexandra C. Brown, Emma de Jong, Izabela Galvao, Alen Faiz, Anthony Bosco, Jay C. Horvat, Philip Hansbro, Chantal Donovan
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Lung transcriptomics studies in asthma have provided valuable information in the whole lung context, however, deciphering the individual contributions of the airway and parenchyma in disease pathogenesis may expedite the development of novel
Externí odkaz:
https://doaj.org/article/911ea9c2ab394ba2934f8c80d24c27d0
Autor:
Huayi Feng, Tao Wang, Jiali Ye, Yang Yang, Xing Huang, Dong Lai, Zheng Lv, Yan Huang, Xu Zhang
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Background Spi-1 proto-oncogene (SPI1), which encodes an ETS-domain transcription factor, can activate gene expression in myeloid and lymphoid lineages. The role of SPI1 in the tumor immune microenvironment in clear cell renal cell carcinoma
Externí odkaz:
https://doaj.org/article/be121d32915d4fabbef2d45557b4162c
Publikováno v:
Renal Failure, Vol 44, Iss 1, Pp 1819-1832 (2022)
Background/Aim Uremic cardiomyopathy (UCM) is a characteristic cardiac pathology that is commonly found in patients with chronic kidney disease. This study dissected the mechanism of SPI1 in myocardial fibrosis and inflammation induced by UCM through
Externí odkaz:
https://doaj.org/article/4ca5be52f40847ef8c821be2d7c3dc4a
Autor:
Xiao-Di Chen, Jing Xie, Yong Wei, Ji-Feng Yu, Ye Cao, Lu Xiao, Xue-Jing Wu, Cong-Jian Mao, Run-Min Kang, Yong-Gang Ye
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionDespite long-term integrated control programs for Eimeria stiedai infection in China, hepatic coccidiosis in rabbits persists. Th1, Th2, Th17, Treg, Th9, and Th21 cells are involved in immune responses during pathogen infection. It is unc
Externí odkaz:
https://doaj.org/article/bec69e3e19c444ad96917ac8dddecf8b
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Akademický článek
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