Substance P-expressing neurons in the superficial dorsal horn of the mouse spinal cord: insights into their functions and their roles in synaptic circuits

Autor: Miruna Costreie, Erika Polgár, Allen C. Dickie, Oğuz Akar, Andrew M. Bell, Maria Gutierrez-Mecinas, Masahiko Watanabe, Andrew J. Todd

Publikováno v: Neuroscience

Highlights • Substance P-expressing radial cells in lamina II receive half of their excitatory synaptic input from other interneurons. • They are preferentially innervated by transient central cells that express eGFP in a GRP-eGFP mouse line. •

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c71b05c3830273d361951bbbf377255
https://eprints.gla.ac.uk/219536/1/219536.pdf

Expression of huntingtin-associated protein 1 in adult mouse dorsal root ganglia and its neurochemical characterization in reference to sensory neuron subpopulations

Autor: Taiga Ishino, Naoki Maeda, Emi Miyasato, Mir Rubayet Jahan, Abu Md Mamun Tarif, Koh Shinoda, Nabiul Islam, Koh-hei Masumoto, Kanako Nozaki, Akie Yanai

Publikováno v: IBRO Reports, Vol 9, Iss, Pp 258-269 (2020)
IBRO Reports

Highlights • This study is the first to examine HAP1-expression in dorsal root ganglia (DRG). • HAP1 is highly co-expressed with the markers of nociceptive/proprioceptive neurons. • HAP1 is completely lacking in the touch-sensitive DRG neurons.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1d372f4e3a93b9bd429cc22726a04d
https://pubmed.ncbi.nlm.nih.gov/33089002

Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma

Autor: Yujie Zhang, Tao Sun, Qin Guo, Chunhui Ruan, Xinli Chen, Xi He, Qinjun Chen, Chen Jiang, Lisha Liu, Yifei Lu, Yu Zhang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 8, Iss 1, Pp 85-96 (2018)
Acta Pharmaceutica Sinica. B

The blood–brain barrier (BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme (GBM). The present study exploits albumin as drug delivery vehicle to promote the chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c201de0082f6a976026b959a2c466fa
http://www.sciencedirect.com/science/article/pii/S2211383517302824

Neuropeptides and ATP signaling in the trigeminal ganglion

Autor: Haruki Iwai, Atsushi Yamanaka, Eriko Kuramoto, Tetsuya Goto

Publikováno v: Japanese Dental Science Review, Vol 53, Iss 4, Pp 117-124 (2017)
The Japanese Dental Science Review

Summary Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08bad87f1453e7a1040bbc9c7169ba7
https://doi.org/10.1016/j.jdsr.2017.01.003

scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3

Autor: Robert O. Heuckeroth, Beth A. Maguire, Joel C. Bornstein, Christina M. Wright, Deepika R. Kothakapa, Fernanda Abani Mafra, Michael Gonzalez, Kristen M. Smith-Edwards, Jessica B. Anderson, Sabine Schneider, Brian M. Davis, Tao Gao, Marthe J. Howard, Tricia A. Missall, Anita J. L. Leembruggen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1548-1592.e1 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background and Aims Bowel function requires coordinated activity of diverse enteric neuron subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate development of novel therapeutic approaches to treat devastating enteric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6535e3beeee808b007d45b843af28cb3
https://doi.org/10.1016/j.jcmgh.2020.12.014