SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice

Autor: Yan Wang, Sheng Zhang, Zhaohui Lan, Vui Doan, Bokyung Kim, Sihan Liu, Meina Zhu, Vanessa L. Hull, Sami Rihani, Chun-Li Zhang, John A. Gray, Fuzheng Guo

Publikováno v: Cell reports, vol 41, iss 12

Children with SOX2 deficiency develop ocular disorders and extra-ocular CNS anomalies. Animal data show that SOX2 is essential for retinal and neural stem cell development. In the CNS parenchyma, SOX2 is primarily expressed in astroglial and oligoden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b415b3bd2db944d5f99dde8eef2e391
https://escholarship.org/uc/item/2c74n4x4

SOX2 Disorder

Autor: Williamson KA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom, Yates TM; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom, FitzPatrick DR; Consultant in Pediatric Genetics, MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

Publikováno v: 1993.