Zobrazeno 1 - 10
of 41
pro vyhledávání: '"SOTEROULA CHRISTOU"'
Autor:
Basma Naiisseh, Panayiota L. Papasavva, Nikoletta Y. Papaioannou, Marios Tomazou, Lola Koniali, Xenia Felekis, Constantina G. Constantinou, Maria Sitarou, Soteroula Christou, Marina Kleanthous, Carsten W. Lederer, Petros Patsali
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102183- (2024)
β-Thalassemia is brought about by defective β-globin (HBB [hemoglobin subunit β]) formation and, in severe cases, requires regular blood transfusion and iron chelation for survival. Genome editing of hematopoietic stem cells allows correction of u
Externí odkaz:
https://doaj.org/article/b91282ff2bb6418eb5eea22e8d27f4eb
Autor:
SALVATORE DI MAIO, VINCENZO DE SANCTIS, PIERLUIGI MARZUILLO, CHRISTOS KATTAMIS, SHAHINA DAAR, MEHERAN KARIMI, SAKI FOROUGH, ATANAS BANKEV, VALERIA KALEVA, SOTEROULA CHRISTOU, CARMELO FORTUGNO, POLYXENI DELAPORTA, ASHRAF T SOLIMAN, PLOUTARCHOS TZOULIS
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 15, Iss 1 (2023)
Abstract. Objective: To evaluate the age at menarche and menstrual characteristics in patients with transfusion-dependent thalassemia (TDT) who started early chelation therapy (≤ 3 years) with a variety of chelating agents. Design: A retrospective
Externí odkaz:
https://doaj.org/article/f91a52e79be64c3eb1b707a4bfbeb961
Autor:
José Martín Solórzano González, Sara Isabel Reidel, Ines Labidi, Claire Diot Lefebvre, Stella Tamana, Victoria Gutierrez Valle, Eduard van Beers, Raffaella Colombatti, Paola Bianchi, Angelo Loris Brunetta, Dore Peereboom, Frédéric Galactéros, Giovanna Russo, Antonis Kattamis, Laurence Dedeken, Joachim Kunz, Elena Cela, Celeste Bento, Ulf Tedgard, Andreas Glenthøj, Soteroula Christou, Marina Kleanthous, Petros Kountouris, Beatrice Gulbis, Maria Del Mar Mañú Pereira
Publikováno v:
HemaSphere, Vol 7, p e13208ab (2023)
Externí odkaz:
https://doaj.org/article/dda4d76b94d94600b11ff5e166a87910
Autor:
Michael Angastiniotis, Soteroula Christou, Annita Kolnakou, Evangelia Pangalou, Irene Savvidou, Dimitrios Farmakis, Androulla Eleftheriou
Publikováno v:
Thalassemia Reports, Vol 12, Iss 4, Pp 143-156 (2022)
Haemoglobinopathies, including thalassaemias and sickle-cell syndromes, are demanding, lifelong conditions that pose a significant burden to patients, families, and healthcare systems. Despite the therapeutic advances and the resulting improvements i
Externí odkaz:
https://doaj.org/article/ad3490e6c9b5469a8614430bb61f0dd9
Autor:
Coralea Stephanou, Miranda Petrou, Petros Kountouris, Christiana Makariou, Soteroula Christou, Michael Hadjigavriel, Marina Kleanthous, Thessalia Papasavva
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 296 (2024)
The +33 C>G variant [NM_000518.5(HBB):c.-18C>G] in the 5′ untranslated region (UTR) of the β-globin gene is described in the literature as both mild and silent, while it causes a phenotype of thalassemia intermedia in the presence of a severe β-t
Externí odkaz:
https://doaj.org/article/602ef8c19edc49abad13e789fc66f16f
Autor:
Lola Koniali, Christina Flouri, Markela I. Kostopoulou, Nikoletta Y. Papaioannou, Panayiota L. Papasavva, Basma Naiisseh, Coralea Stephanou, Anthi Demetriadou, Maria Sitarou, Soteroula Christou, Michael N. Antoniou, Marina Kleanthous, Petros Patsali, Carsten W. Lederer
Publikováno v:
Cells, Vol 12, Iss 24, p 2848 (2023)
Therapy via the gene addition of the anti-sickling βAS3-globin transgene is potentially curative for all β-hemoglobinopathies and therefore of particular clinical and commercial interest. This study investigates GLOBE-based lentiviral vectors (LVs)
Externí odkaz:
https://doaj.org/article/ced4c48ca6ed44b9a025e89953ea0fe4
Autor:
Nikoletta Y. Papaioannou, Petros Patsali, Basma Naiisseh, Panayiota L. Papasavva, Lola Koniali, Ryo Kurita, Yukio Nakamura, Soteroula Christou, Maria Sitarou, Claudio Mussolino, Toni Cathomen, Marina Kleanthous, Carsten W. Lederer
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Introduction: Genome editing tools, such as CRISPR/Cas, TALE nucleases and, more recently, double-strand-break-independent editors, have been successfully used for gene therapy and reverse genetics. Among various challenges in the field, tolerable an
Externí odkaz:
https://doaj.org/article/0fbfbdfb3fde4f0eb2824e45f9241f24
Autor:
Aikaterini Nanou, Chrisavgi Toumpeki, Pavlos Fanis, Nicoletta Bianchi, Lucia Carmela Cosenza, Cristina Zuccato, George Sentis, Giorgos Giagkas, Coralea Stephanou, Marios Phylactides, Soteroula Christou, Michalis Hadjigavriel, Maria Sitarou, Carsten W. Lederer, Roberto Gambari, Marina Kleanthous, Eleni Katsantoni
Publikováno v:
Haematologica, Vol 106, Iss 4 (2020)
Externí odkaz:
https://doaj.org/article/3de2f56a7d294f9faa59acb2b535f529
Autor:
Petros Kountouris, Kyriaki Michailidou, Soteroula Christou, Michael Hadjigavriel, Maria Sitarou, Anita Kolnagou, Marina Kleanthous, Paul Telfer
Publikováno v:
Haematologica, Vol 106, Iss 9 (2020)
Initiation of regular transfusion in transfusion-dependent thalassemia (TDT) is based on the assessment of clinical phenotype. Pathogenic HBB variants causing β-thalassemia are important determinants of phenotype and could be used to aid decision ma
Externí odkaz:
https://doaj.org/article/3e5b766d488f44e49d259aa3a4c76cbb
Autor:
Alisa Dong, Valentina Ghiaccio, Irene Motta, Shuling Guo, Raechel Peralta, Susan M. Freier, Andy Watt, Sagar Damle, Yasuhiro Ikawa, Danuta Jarocha, Maxwell Chappell, Coralea Stephanou, Paola Delbini, Connie Chen, Soteroula Christou, Marina Kleanthous, Kim Smith-Whitley, Deepa Manwani, Carla Casu, Osheiza Abdulmalik, Maria Domenica Cappellini, Stefano Rivella, Laura Breda
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
β-thalassemia is a disorder caused by altered hemoglobin protein synthesis and affects individuals worldwide. Severe forms of the disease, left untreated, can result in death before the age of 3 years (1). The standard of care consists of chronic an
Externí odkaz:
https://doaj.org/article/0a9af0f8d129480daf7391c3232c9430