Zobrazeno 1 - 6
of 6
pro vyhledávání: '"SOS, son of sevenless"'
Autor:
Mingfei Ji, Jie Chen, Chuan Lv, Xinyi Li, Zongtao Chai, Jun Pu, Yuran Qiu, Duan Ni, Jian Zhang, Yuanhao Wang, Shaoyong Lu
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3433-3446 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3433-3446 (2021)
RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301d6dec04ce4d283571a3cfb861136b
http://europepmc.org/articles/PMC8642438
http://europepmc.org/articles/PMC8642438
Autor:
Hemant Kumar, Yoav Peleg, Ariel Erijman, Julia M. Shifman, Ashish Noronha, Anamika Singh, Yosef Yarden
Publikováno v:
The Journal of Biological Chemistry
Within the superfamily of small GTPases, Ras appears to be the master regulator of such processes as cell cycle progression, cell division, and apoptosis. Several oncogenic Ras mutations at amino acid positions 12, 13, and 61 have been identified tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6e501be983b2ce2666c2a21b78ab3a
http://europepmc.org/articles/PMC8605244
http://europepmc.org/articles/PMC8605244
Autor:
Gilbert J. Cote, Nguyet Minh Hoang, Oorvashi Roy Puli, Marie Claude Hofmann, Heather E. Danysh, Elena McBeath, Brian P. Danysh, Maria E. Cabanillas, Deepankar K. Sinha, Reid T. Powell
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 11, Pp 1121-1134 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
The ETS family of transcription factors is involved in several normal remodeling events and pathological processes including tumor progression. ETS transcription factors are divided into subfamilies based on the sequence and location of the ETS domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca0dc81b99cd04b707e47e050584981
http://www.sciencedirect.com/science/article/pii/S1476558618304299
http://www.sciencedirect.com/science/article/pii/S1476558618304299
Autor:
Ke Yao, Do Young Lim, Zigang Dong, Feng Zhu, Tatyana A. Zykova, Haitao Li, Ruihua Bai, Lei Wang, Ann M. Bode
Publikováno v:
EBioMedicine
EBioMedicine, Vol 18, Iss C, Pp 73-82 (2017)
EBioMedicine, Vol 18, Iss C, Pp 73-82 (2017)
Approximately 90% of all cancer deaths arise from the metastatic dissemination of primary tumors. Metastasis is the most lethal attribute of colorectal cancer. New data regarding the molecules contributing to the metastatic phenotype, the pathways th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f26f8617e069aef41bcee3a224392da
https://pubmed.ncbi.nlm.nih.gov/28412249
https://pubmed.ncbi.nlm.nih.gov/28412249
Autor:
Simone Kunzelmann, Martin R. Webb
Publikováno v:
Biochemical Journal
The development of novel fluorescence methods for the detection of key biomolecules is of great interest, both in basic research and in drug discovery. Particularly relevant and widespread molecules in cells are ADP and GDP, which are the products of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188663940988052ec22c1c9c00dfb3f8
http://europepmc.org/articles/PMC3204873
http://europepmc.org/articles/PMC3204873
Autor:
Qiu Y; Department of Urology, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, China.; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China., Wang Y; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China., Chai Z; Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China., Ni D; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China., Li X; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China., Pu J; Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200120, China., Chen J; Department of Urology, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, China., Zhang J; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China., Lu S; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China., Lv C; Department of Plastic Surgery, Changhai Hospital, Naval Military Medical University, Shanghai 200438, China., Ji M; Department of Urology, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Nov; Vol. 11 (11), pp. 3433-3446. Date of Electronic Publication: 2021 Feb 25.