Identification of novel quinazoline derivatives as potent antiplasmodial agents

Autor: Johan Schultz, Dany Pechalrieu, Sergio Valente, Anne Bouchut, Tina S. Skinner-Adams, Giancarlo Fabrizi, Paola B. Arimondo, Urban Hoglund, Katherine T. Andrews, Roberta Mazzone, Sophia Lafitte, Antonello Mai, Alessia Lucidi, Christine Pierrot, Ming Jang Chua, Jamal Khalife, Dante Rotili

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 161, pp.277-291. ⟨10.1016/j.ejmech.2018.10.041⟩
European Journal of Medicinal Chemistry, 2019, 161, pp.277-291. ⟨10.1016/j.ejmech.2018.10.041⟩

International audience; Despite the recent reductions in the global burden of malaria, this disease remains a devastating cause of death in tropical and subtropical regions. As there is no broadly effective vaccine for malaria, prevention and treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a86e82c36d3a424ed430d178a588e9
http://hdl.handle.net/20.500.12210/34198

A role for CD4+ and CD8+ cells and not for CD25+ cells in the control of Plasmodium berghei Anka blood stage parasites in rats

Autor: Dit Vampouille A Acroute, Christine Pierrot, Daniel Dive, Jamal Khalife, Sophia Lafitte

Publikováno v: Parasite, Vol 17, Iss 1, Pp 53-60 (2010)

In previous studies of the infection of rats by P. berghei Anka, we have shown that primary blood stage infection induced the expansion of CD4+ T cells and CD8+ T cells in adult resistant rats while the number of CD4+CD25+ cells was found to be highe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191856543e29ae7158aa1b40f43bb002
https://doaj.org/article/fdc3fddbabaa4081b41a14eb73c3fb29

X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model

Autor: SOPHIE GAUBERT, ALEXANDRA VIANA DA COSTA, CLAUDE-ALAIN MAURAGE, EDUARDO CÉSAR SANTOS LIMA, JOSETTE FONTAINE, SOPHIA LAFITTE, PAOLA MINOPRIO, ANDRÉ CAPRON, JEAN-MARIE GRZYCH

Publikováno v: Parasite Immunology. 21:89-101

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0d36a20ea607f065302a7cd3a118279
https://doi.org/10.1111/cge.1999.21.2.89

Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy

Autor: Sophia Lafitte, Raymond J. Pierce, Jamal Khalife, Géraldine Tellier, Katia Cailliau-Maggio, Jean-François Bodart, Christine Pierrot, Hadidjatou Kalamou, Aline Fréville, Alain Martoriati

Publikováno v: BMC Biology
BMC Biology, 2013, 11 (1), pp.80. ⟨10.1186/1741-7007-11-80⟩
BMC Biology, BioMed Central, 2013, 11 (1), pp.80. ⟨10.1186/1741-7007-11-80⟩

Background It is clear that the coordinated and reciprocal actions of kinases and phosphatases are fundamental in the regulation of development and growth of the malaria parasite. Protein Phosphatase type 1 is a key enzyme playing diverse and essenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff49f6ea9d08843e28a04a6a5ebfc79
https://doi.org/10.1186/1741-7007-11-80

Identification of a Novel Antigen of Schistosoma mansoni Shared with Plasmodium falciparum and Evaluation of Different Cross-Reactive Antibody Subclasses Induced by Human Schistosomiasis and Malaria

Autor: Hélène Lallet, Jamal Khalife, Christine Pierrot, David W. Dunne, Monique Capron, Shona Wilson, Wassim Daher, Sophia Lafitte, Frances M. Jones

Plasmodium falciparumandSchistosoma mansoniare often found in human coinfections, and cross-reactive antibodies to different components of the two parasites have been detected. In this work, we identified a cross-reactiveS. mansonigene product, refer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a7cd62e3afc559671e2788d277d9d0
https://europepmc.org/articles/PMC1479256/