A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals

Autor: David Shum, Seung Kew Yoon, Marc Peter Windisch, Soonju Park, Eva Zusinaite, Eunji Jo, Denis E. Kainov, Jaewon Yang, Pil Soo Sung, Alexander König

Publikováno v: JHEP Reports
JHEP Reports, Vol 3, Iss 4, Pp 100296-(2021)

Background & Aims Chronic hepatitis B is an incurable disease. Addressing the unmet medical need for therapies has been hampered by a lack of suitable cell culture models to investigate the HBV life cycle in a single experimental setup. We sought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d39818aec9a96715b2a465ff2da762
https://hdl.handle.net/11250/3045132

A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals.

Autor: Yang J; Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea., König A; Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea., Park S; Screening Discovery Platform, Institut Pasteur Korea, Seongnam-si, South Korea., Jo E; Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea., Sung PS; Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.; Catholic University Liver Research Center, The Catholic University of Korea, Seoul, South Korea., Yoon SK; Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.; Catholic University Liver Research Center, The Catholic University of Korea, Seoul, South Korea., Zusinaite E; Institute of Technology, University of Tartu, Tartu, Estonia., Kainov D; Institute of Technology, University of Tartu, Tartu, Estonia.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Shum D; Screening Discovery Platform, Institut Pasteur Korea, Seongnam-si, South Korea., Windisch MP; Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea.; Division of Bio-Medical Science and Technology, University of Science and Technology, Daejeon, South Korea.

Publikováno v: JHEP reports : innovation in hepatology [JHEP Rep] 2021 Apr 30; Vol. 3 (4), pp. 100296. Date of Electronic Publication: 2021 Apr 30 (Print Publication: 2021).