Zobrazeno 1 - 10
of 55
pro vyhledávání: '"SONG-YANG ZHANG"'
Publikováno v:
Endocrinology and Metabolism, Vol 39, Iss 4, Pp 559-568 (2024)
The central nervous system regulates feeding, weight and glucose homeostasis in rodents and humans, but the site-specific mechanisms remain unclear. The dorsal vagal complex in the brainstem that contains the nucleus of the solitary tract (NTS) and a
Externí odkaz:
https://doaj.org/article/2cb16dcf7cef4747ac49b2791d427179
Autor:
Pengcheng Wang, Guangyi Zeng, Yu Yan, Song-yang Zhang, Yongqiang Dong, Yangming Zhang, Xingzhong Zhang, Huiying Liu, Zhipeng Zhang, Changtao Jiang, Yanli Pang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1899-1912 (2022)
Atherosclerosis is a chronic multifactorial cardiovascular disease. Western diets have been reported to affect atherosclerosis through regulating adipose function. In high cholesterol diet-fed ApoE–/– mice, adipocyte HIF-1α deficiency or direct
Externí odkaz:
https://doaj.org/article/229f5c0dfda040a3848db3d9e530daf3
Autor:
Song-Yang Zhang, Tony K. T. Lam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-3 (2022)
AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epitheliu
Externí odkaz:
https://doaj.org/article/9bda580c853842f69b7ec4e4552ea866
Autor:
T. M. Zaved Waise, Mozhgan Rasti, Frank A. Duca, Song-Yang Zhang, Paige V. Bauer, Christopher J. Rhodes, Tony K. T. Lam
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the
Externí odkaz:
https://doaj.org/article/ed627460bddc4b5ba603759563251b83
Autor:
Rosa J.W. Li, Battsetseg Batchuluun, Song-Yang Zhang, Mona A. Abraham, Beini Wang, Yu-Mi Lim, Jessica T.Y. Yue, Tony K.T. Lam
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102366- (2021)
Summary: Hypothalamic regulation of lipid and glucose homeostasis is emerging, but whether the dorsal vagal complex (DVC) senses nutrients and regulates hepatic nutrient metabolism remains unclear. Here, we found in rats DVC oleic acid infusion suppr
Externí odkaz:
https://doaj.org/article/372210e912e1406abc4ba8cdaacfc1b7
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101132- (2021)
Objective: The mechanism of nutrient sensing in the upper small intestine (USI) and ileum that regulates glucose homeostasis remains elusive. Short-term high-fat (HF) feeding increases taurochenodeoxycholic acid (TCDCA; an agonist of farnesoid X rece
Externí odkaz:
https://doaj.org/article/1a10f139ef404633a669e702e42eab74
Publikováno v:
Molecular Metabolism, Vol 39, Iss , Pp - (2020)
Background: In response to energy abundant or deprived conditions, nutrients and hormones activate hypothalamic pathways to maintain energy and glucose homeostasis. The underlying CNS mechanisms, however, remain elusive in rodents and humans. Scope o
Externí odkaz:
https://doaj.org/article/18b65e77c68d4ccba89c0d22877285d2
Autor:
Song-Yang Zhang, Yong-Qiang Dong, Pengcheng Wang, Xingzhong Zhang, Yu Yan, Lulu Sun, Bo Liu, Dafang Zhang, Heng Zhang, Huiying Liu, Wei Kong, Gang Hu, Yatrik M. Shah, Frank J. Gonzalez, Xian Wang, Changtao Jiang
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 202-216 (2018)
The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy
Externí odkaz:
https://doaj.org/article/289d7aae1b0c4d0a971b52431bda5090
Autor:
Song-Yang Zhang, Danqing Shao, Huiying Liu, Juan Feng, Baihuan Feng, Xiaoming Song, Qian Zhao, Ming Chu, Changtao Jiang, Wei Huang, Xian Wang
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 459-469 (2017)
Particulate matter with an aerodynamic diameter less than 2.5 μM (PM2.5) is one of the major environmental pollutants in China. In this study, we carried out a metabolomics profile study on PM2.5-induced inflammation. PM2.5 from Beijing, China, was
Externí odkaz:
https://doaj.org/article/d41661dd99684cc6b608ab3c06e0faeb
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Hypoxia-inducible factor (HIF) 1α is a metabolic regulator that plays an important role in immunologic responses. Previous studies have demonstrated that HIF1α participates in the M1 polarization of macrophages. To clarify the mechanism of HIF1α-i
Externí odkaz:
https://doaj.org/article/a36f537ffb1d492e946f3d40ae3302f1