Potassium/sodium cation carriers robustly up-regulate CD20 antigen by targeting MYC, and synergize with anti-CD20 immunotherapies to eliminate malignant B cells

Autor: Anna Torun, Aleksandra Zdanowicz, Nina Miazek-Zapala, Piotr Zapala, Bhaskar Pradhan, Marta Jedrzejczyk, Andrzej Ciechanowicz, Zofia Pilch, Marcin Skorzynski, Mikołaj Słabicki, Grzegorz Rymkiewicz, Joanna Barankiewicz, Claudio Martines, Luca Laurenti, Marta Struga, Magdalena Winiarska, Jakub Golab, Magdalena Kucia, Mariusz Z. Ratajczak, Adam Huczynski, Dinis P. Calado, Dimitar G. Efremov, Abdessamad Zerrouqi, Beata Pyrzynska

Publikováno v: Haematologica, Vol 999, Iss 1 (2024)

Our investigation uncovers that nanomolar concentrations of salinomycin, monensin, nigericin, and narasin (a group of potassium/sodium cation carriers) robustly enhance surface expression of CD20 antigen in B-cell-derived tumor cells, including prima

Externí odkaz: https://doaj.org/article/76b782877c9b4f9ebf19e99dbbf87ecd

Potassium/sodium cation carriers robustly up-regulate CD20 antigen by targeting MYC, and synergize with anti-CD20 immunotherapies to eliminate malignant B cells.

Autor: Torun A; Medical University of Warsaw, Warsaw., Zdanowicz A; Medical University of Warsaw, Warsaw, Poland; Doctoral School, Medical University of Warsaw, Warsaw., Miazek-Zapala N; Medical University of Warsaw, Warsaw., Zapala P; Medical University of Warsaw, Warsaw., Pradhan B; Medical University of Warsaw, Warsaw, Poland; Doctoral School, Medical University of Warsaw, Warsaw., Jedrzejczyk M; Adam Mickiewicz University, Poznan., Ciechanowicz A; Medical University of Warsaw, Warsaw., Pilch Z; Medical University of Warsaw, Warsaw., Skorzynski M; Medical University of Warsaw, Warsaw., Słabicki M; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA., Rymkiewicz G; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw., Barankiewicz J; Institute of Hematology and Transfusion Medicine, Warsaw., Martines C; Molecular Hematology Unit, International Centre for Genetic Engineering and Biotechnology, Trieste., Laurenti L; Hematology Unit, Fundazione Policlinico Universitario A Gemelli IRCCS, Rome., Struga M; Medical University of Warsaw, Warsaw., Winiarska M; Medical University of Warsaw, Warsaw., Golab J; Medical University of Warsaw, Warsaw., Kucia M; Medical University of Warsaw, Warsaw., Ratajczak MZ; Medical University of Warsaw, Warsaw., Huczynski A; Adam Mickiewicz University, Poznan., Calado DP; The Francis Crick Institute, London, United Kingdom., Efremov DG; Molecular Hematology Unit, International Centre for Genetic Engineering and Biotechnology, Trieste., Zerrouqi A; Medical University of Warsaw, Warsaw, Poland; Senior authors., Pyrzynska B; Medical University of Warsaw, Warsaw, Poland; Senior authors. beata.pyrzynska@wum.edu.pl.

Publikováno v: Haematologica [Haematologica] 2024 Dec 19. Date of Electronic Publication: 2024 Dec 19.

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