Zobrazeno 1 - 10
of 476
pro vyhledávání: '"SOD1G93A"'
Autor:
Megan C. Baird, Shibi B. Likhite, Tatyana A. Vetter, Joseph R. Caporale, Holly B. Girard, Florence S. Roussel, Abigail E. Howard, Maura K. Schwartz, Addison R. Reed, Abuzar Kaleem, Xiaojin Zhang, Kathrin C. Meyer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101312- (2024)
Neuroinflammation is a miscreant in accelerating progression of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). However, treatments targeting neuroinflammation alone have led to disappointing results in clinical trials
Externí odkaz:
https://doaj.org/article/e03e2e54945a4ebb95e805af30019e49
Autor:
Illari Salvatori, Valentina Nesci, Alida Spalloni, Veronica Marabitti, Maurizio Muzzi, Henri Zenuni, Silvia Scaricamazza, Marco Rosina, Gianmarco Fenili, Mariangela Goglia, Laura Boffa, Roberto Massa, Sandra Moreno, Nicola Biagio Mercuri, Francesca Nazio, Patrizia Longone, Alberto Ferri, Cristiana Valle
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3251 (2024)
Amyotrophic Lateral Sclerosis (ALS) is considered the prototype of motor neuron disease, characterized by motor neuron loss and muscle waste. A well-established pathogenic hallmark of ALS is mitochondrial failure, leading to bioenergetic deficits. So
Externí odkaz:
https://doaj.org/article/0f689b9b5fad4ddcbc4869bc4873aaeb
Autor:
Kazuki Adachi, Kota Miyata, Yukino Chida, Mikako Hirose, Yuta Morisaki, Koji Yamanaka, Hidemi Misawa
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in which non-cell-autonomous processes have been proposed as its cause. Non-neuronal cells that constitute the environment around motor neurons are known to mediate the pathogenesis
Externí odkaz:
https://doaj.org/article/fd201da49db041519349c083f82cb56f
Autor:
Long-Fang Tu, Tian-Ze Zhang, Yang-Fan Zhou, Qing-Qing Zhou, Hai-Biao Gong, Lei Liang, Lin-Na Hai, Nan-Xin You, Yang Su, Yong-Jun Chen, Xu-Kai Mo, Chang-Zheng Shi, Liang-Ping Luo, Wan-Yang Sun, Wen-Jun Duan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He
Publikováno v:
Journal of Advanced Research, Vol 43, Iss , Pp 205-218 (2023)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by oxidative stress that triggers motor neurons loss in the brain and spinal cord. However, the mechanisms underlying the exact role of oxidative stress in A
Externí odkaz:
https://doaj.org/article/593e781658d74dc986e917b9d16ed2ce
Autor:
Biying Yang, Jingrui Pan, Xiao-Ni Zhang, Hongxuan Wang, Lei He, Xiaoming Rong, Xiangpen Li, Ying Peng
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106210- (2023)
The progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS) is caused by a decline in motor neuron function, resulting in worsened motor impairments, malnutrition, respiratory failure and mortality, and there is a lack of effective
Externí odkaz:
https://doaj.org/article/1432badefe7748058dc015d617a7d069
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Akademický článek
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Autor:
Antonio Mazzaro, Veronica Vita, Marco Ronfini, Irene Casola, Arianna Klein, Gabriella Dobrowolny, Gianni Sorarù, Antonio Musarò, Marco Mongillo, Tania Zaglia
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Rationale: The anatomical substrate of skeletal muscle autonomic innervation has remained underappreciated since it was described many decades ago. As such, the structural and functional features of muscle sympathetic innervation are largely undeterm
Externí odkaz:
https://doaj.org/article/41261813587d47b7a39ec443bb61dd24
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that widely affects motor neurons of the CNS. About 20% of patients with ALS have familial ALS (fALS). One of the classic models of ALS are SOD1G93A mice. Misfolded SOD1 p
Externí odkaz:
https://doaj.org/article/4c5a654ac8a04b3b9d602e874f88db63