Zobrazeno 1 - 10
of 36
pro vyhledávání: '"SOCS, suppressor of cytokine signaling"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes, and their development is intricately connected to the disruption of the JAK-STAT signaling pathway, where SOCS proteins play crucial roles. Conditions such as
Externí odkaz:
https://doaj.org/article/83a05da4c8114d09bfed8f8cd1e0ef7b
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020
https://doi.org/10.1016/j.apsb.2020.12.020
Autor:
Jorge Quarleri, M. Victoria Delpino
Publikováno v:
Cytokine & Growth Factor Reviews
SARS-CoV-2 is a recently identified coronavirus accountable for the current pandemic disease known as COVID-19. Different patterns of disease progression infer a diverse host immune response, with interferon (IFN) being pivotal. IFN-I and III are pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0ed2f72291aa86d6f23c42f116bc46
https://doi.org/10.1016/j.cytogfr.2021.01.003
https://doi.org/10.1016/j.cytogfr.2021.01.003
Publikováno v:
Molecular & Cellular Proteomics : MCP
Mol Cell Proteomics
Mol Cell Proteomics
Ubiquitination is a posttranslational protein modification that has been shown to have a range of effects, including regulation of protein function, interaction, localization, and degradation. We have previously shown that the muscle-specific ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88a5086222dd382a409e9eec910c431
http://europepmc.org/articles/PMC8042406
http://europepmc.org/articles/PMC8042406
Autor:
Christian Bogdan
Publikováno v:
Cytokine
Cytokine: X, Vol 2, Iss 4, Pp 100041-(2020)
Cytokine: X, Vol 2, Iss 4, Pp 100041-(2020)
Highlights • Macrophages serve as replicative niche, antimicrobial effectors or immunoregulators. • Functional diversity results from cytokines, micromilieu factors and metabolites. • Micro milieu factors include hypoxia, tonicity and amino aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c346b1974962b6f0934f117cb72355
https://pubmed.ncbi.nlm.nih.gov/33604563
https://pubmed.ncbi.nlm.nih.gov/33604563
Autor:
Craig D. Platt, Kasey Gauthier, Sally H. Vitali, Janet Chou, Rachael F. Grace, Raif S. Geha, Sridevi Devana, Sabrina Weeks, Douglas R. McDonald, George Maher, Adrienne G. Randolph, Pui Y. Lee
Publikováno v:
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Background We studied 2 unrelated patients with immune thrombocytopenia and autoimmune hemolytic anemia in the setting of acute infections. One patient developed multisystem inflammatory syndrome in children in the setting of a severe acute respirato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c623b69478e71243521968ac650a97c
http://europepmc.org/articles/PMC7445138
http://europepmc.org/articles/PMC7445138
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Stat3, a major signaling molecule for proinflammatory cytokines including IL-6, was activated both in inflammatory cells and in SMC in the aortic walls of human AD and mouse AD model. • SMC-specific deletion of S
Highlights • Stat3, a major signaling molecule for proinflammatory cytokines including IL-6, was activated both in inflammatory cells and in SMC in the aortic walls of human AD and mouse AD model. • SMC-specific deletion of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97e00503172b3927b073b90216d64ddb
https://pubmed.ncbi.nlm.nih.gov/32140621
https://pubmed.ncbi.nlm.nih.gov/32140621
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 27, Iss, Pp 115-125 (2021)
Journal of Advanced Research, Vol 27, Iss, Pp 115-125 (2021)
Graphical abstract
Highlight • H2S deficiency derived from CSE depletion contributes to the vascular remodeling and transformation of vascular smooth muscle cells. • PPARδ/SOCS3 signaling pathway is decreased in CSE/H2S deficiency-associate
Highlight • H2S deficiency derived from CSE depletion contributes to the vascular remodeling and transformation of vascular smooth muscle cells. • PPARδ/SOCS3 signaling pathway is decreased in CSE/H2S deficiency-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ffbde171a5ffead26f56bfea788c00
https://pubmed.ncbi.nlm.nih.gov/33318871
https://pubmed.ncbi.nlm.nih.gov/33318871
Akademický článek
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Autor:
Tomomi Miyamoto, Eiki Takahashi, Ichiro Miyoshi, Natsuko Saito, Atsushi Asano, Yoshinori Shimamoto, Kohei Washio, Sanae Fukushima, Shunsuke Kimura, Chitoku Toda, Misato Amagasa, Hiroshi Kitamura, Chieko Nishioka, Shiki Okamoto
Publikováno v:
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 322-329 (2017)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
We previously reported that ubiquitin-specific protease (USP) 2 in macrophages down-regulates genes associated with metabolic diseases, suggesting a putative anti-diabetic role for USP2 in macrophages. In this study, we evaluate this role at both cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db21366930bc0d7858ca686948953bfa
http://hdl.handle.net/10659/00005998
http://hdl.handle.net/10659/00005998