Spongionella Secondary Metabolites Regulate Store Operated Calcium Entry Modulating Mitochondrial Functioning in SH-SY5Y Neuroblastoma Cells

Autor: Jon Andoni Sánchez, Amparo Alfonso, Marta Leirós, Eva Alonso, Mostafa E. Rateb, Marcel Jaspars, Wael E. Houssen, Rainer Ebel, Luís M. Botana

Publikováno v: Cellular Physiology and Biochemistry, Vol 37, Iss 2, Pp 779-792 (2015)

Background/Aims: The effect of four secondary metabolites isolated from sponge Spongionella, gracilins H, A, L and tetrahydroaplysulphurin-1 on Calcium ion (Ca2+) fluxes were studied in SH-SY5Y neuroblastoma cells. Methods and Results: These compound

Externí odkaz: https://doaj.org/article/4285f10d124c485292b98d8dba1c3589

Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels

Autor: Shamin Rahimi, Tengteng Zhao, Ayako Makino, Marisela Rodriguez, Angela Harrington, Shanshan Song, Patricia A. Thistlethwaite, Aleksandra Babicheva, Ramon J. Ayon, Francesca Balistrieri, John Y.-J. Shyy, Jason X.-J. Yuan

Publikováno v: American Journal of Physiology-Cell Physiology. 318:C954-C968

The increase in cytosolic Ca2+ concentration ([Ca2+]cyt) and upregulation of calcium-sensing receptor (CaSR) and stromal interaction molecule 2 (STIM2) along with inhibition of voltage-gated K+ (KV) channels in pulmonary arterial smooth muscle cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c18cc62f8e857b3a055830db6c5f093
https://doi.org/10.1152/ajpcell.00487.2019

Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

Autor: Madelaine Magalì Audero, Natalia Prevarskaya, Alessandra Fiorio Pla

Publikováno v: Int J Mol Sci

Solid tumours are characterised by an altered microenvironment (TME) from the physicochemical point of view, displaying a highly hypoxic and acidic interstitial fluid. Hypoxia results from uncontrolled proliferation, aberrant vascularization and alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7034019079d5c17eeaa00accd1038fdd
http://hdl.handle.net/2318/1871658

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid

Autor: Jean-William Dupuy, Karla Alvarez-Valadez, Alexis Groppi, Claire Lescoat, Jenifer Trepiana, Guido Kroemer, Pierre Vacher, Faten Merhi, Pierre Soubeyran, Mojgan Djavaheri-Mergny

Publikováno v: Cells
Cells, MDPI, 2021, 10 (12), pp.3364. ⟨10.3390/cells10123364⟩
Cells, 2021, 10 (12), pp.3364. ⟨10.3390/cells10123364⟩
Addi. Archivo Digital para la Docencia y la Investigación
instname
Cells, Vol 10, Iss 3364, p 3364 (2021)
Cells; Volume 10; Issue 12; Pages: 3364

Calcium ions (Ca2+) play important and diverse roles in the regulation of autophagy, cell death and differentiation. Here, we investigated the impact of Ca2+ in regulating acute promyelocytic leukemia (APL) cell fate in response to the anti-cancer ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e733dfe52eddf5318e41b0dc4481da02
https://hal.archives-ouvertes.fr/hal-03457279

Comparison of Ca2+ Handling for the Regulation of Vasoconstriction between Rat Coronary and Renal Arteries

Autor: Qiu-Xiong Lin, Ji-Jin Lin, Fang Rao, Xin-Wen Huang, Zhi-Ling Zhou, Lin Liu, Fei-Hong Lian, Min Yang, Zhi-Xin Shan, Hui Yang, Sui Jiang, Meng-Zhen Zhang, Chun-Yu Deng, Su-Juan Kuang

Publikováno v: Journal of Vascular Research. 56:191-203

Background: Ca2+ plays an important role in the regulation of vasoconstriction. Ca2+ signaling is regulated by a number of Ca2+-handling proteins. However, whether differences in Ca2+ handling affect the regulation of vasoconstriction in different ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4217994c4eac963f8248a7bd4ae37c1d
https://doi.org/10.1159/000501614