Zobrazeno 1 - 10
of 232
pro vyhledávání: '"SOAT1"'
Autor:
Nicole Y. Farhat, Derek Alexander, Kyli McKee, James Iben, Jorge L. Rodriguez-Gil, Christopher A. Wassif, Niamh X. Cawley, William E. Balch, Forbes D. Porter
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4217 (2024)
Niemann-Pick disease type C1 (NPC1) is a lysosomal disorder due to impaired intracellular cholesterol transport out of the endolysosomal compartment.. Marked heterogeneity has been observed in individuals with the same NPC1 genotype, thus suggesting
Externí odkaz:
https://doaj.org/article/655a087fd72f40a59361c7ef1111416f
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
Autor:
Chanyue Zhao, Li Li, Chenrui Li, Chengyuan Tang, Juan Cai, Yu Liu, Jinfei Yang, Yiyun Xi, Ming Yang, Na Jiang, Yachun Han, Yan Liu, Shilu Luo, Li Xiao, Lin Sun
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-14 (2022)
Abstract Background Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorders has clinical value in delaying the progression of DKD, but the precise mechanism by which molecules mediat
Externí odkaz:
https://doaj.org/article/af9f574304b546e88f4a17bbe788984d
Autor:
Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun, Fuchu He
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Background Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use. Here, based on our previous study of sterol O-acyltransferase 1 (SOAT1) in hepat
Externí odkaz:
https://doaj.org/article/eb6cedfeb2024e6494046d30dff1a4ca
Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains a major public health problem and its pathogenesis remains unresolved. A recent proteomics study discovered a lipid enzyme Sterol O-acyltransferase (SOAT1) inv
Externí odkaz:
https://doaj.org/article/a0efa4b489ee4fce9e20b43d748c0eba
Autor:
Xuyang Guo, Shaolong Zhou, Zhuo Yang, Zi-An Li, Weihua Hu, Lirui Dai, Wulong Liang, Xinjun Wang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Metabolic reprogramming is a hallmark of glioma, and sterol O-acyltransferase 1 (SOAT1) is an essential target for metabolic therapy. However, the prognostic value of SOAT1 and its association with immune infiltration has not been fully elucidated. U
Externí odkaz:
https://doaj.org/article/8055421aa4114568b261d5aff1679592
Autor:
Taylor C. Harned, Radu V. Stan, Ze Cao, Rajarshi Chakrabarti, Henry N. Higgs, Catherine C. Y. Chang, Ta Yuan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5525 (2023)
Cholesterol is a key component of all mammalian cell membranes. Disruptions in cholesterol metabolism have been observed in the context of various diseases, including neurodegenerative disorders such as Alzheimer’s disease (AD). The genetic and pha
Externí odkaz:
https://doaj.org/article/5caa6aa440cf4cbe8ec2bc52f2f180ce
Autor:
Löhr, Mario, Härtig, Wolfgang, Schulze, Almut, Kroiß, Matthias, Sbiera, Silviu, Lapa, Constantin, Mages, Bianca, Strobel, Sabrina, Hundt, Jennifer Elisabeth, Bohnert, Simone, Kircher, Stefan, Janaki-Raman, Sudha, Monoranu, Camelia-Maria
Targeting molecular alterations as an effective treatment for isocitrate dehydrogenasewildtype glioblastoma (GBM) patients has not yet been established. Sterol-O-Acyl Transferase 1 (SOAT1), a key enzyme in the conversion of endoplasmic reticulum chol
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A89202
https://ul.qucosa.de/api/qucosa%3A89202/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A89202/attachment/ATT-0/
Autor:
Jialin Abuzhalihan, Yong-Tao Wang, Yi-Tong Ma, Zhen-Yan Fu, Yi-Ning Yang, Xiang Ma, Xiao-Mei Li, Fen Liu, Bang-Dang Chen
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-6 (2019)
Abstract Background This study was designed to investigate whether differential DNA methylationin of cholesterol absorption candidate genes can function as a biomarker for patients with coronary heart disease (CHD). Methods DNA methylation levels of
Externí odkaz:
https://doaj.org/article/3f70483d31074273b3e265f3a1ab4ec8
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.