β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins

Autor: Natalia Ninkina, Owen M. Peters, Natalie Connor-Robson, Kirill D. Chaprov, Holger B. Kramer, Dominic J. Withers, Arthur T. Kopylov, Vladimir L. Buchman, Steven Millership, Alex Montoya

Publikováno v: The Journal of Biological Chemistry

Synucleins, a family of three proteins highly expressed in neurons, are predominantly known for the direct involvement of α-synuclein in the etiology and pathogenesis of Parkinson's and certain other neurodegenerative diseases, but their precise phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c25bdcdb04d42ed3e6e25fe31cef99
http://europepmc.org/articles/PMC8633583

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

Autor: Connor-Robson, N, Booth, H, Martin, JG, Gao, B, Li, K, Doig, N, Vowles, J, Browne, C, Klinger, L, Juhasz, P, Klein, C, Cowley, SA, Bolam, P, Hirst, W, Wade-Martins, R

Publikováno v: Neurobiology of Disease, Vol 127, Iss, Pp 512-526 (2019)
Neurobiology of Disease

Background Mutations in LRRK2 are the most common cause of autosomal dominant Parkinson's disease, and the relevance of LRRK2 to the sporadic form of the disease is becoming ever more apparent. It is therefore essential that studies are conducted to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b7268c281d6c7f4627e2a8bb7ba71182
https://orca.cardiff.ac.uk/id/eprint/142163/1/1-s2.0-S0969996119300968-main.pdf

Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice

Autor: Paul C. Keane, Christopher Morris, P.J. Kahle, Peter S. Hanson, Fiona E. N. LeBeau, Ahmad Khundakar, Peter G. Blain, Sarah J. Judge, Philippa D. Hepplewhite, Lina Patterson

Publikováno v: Neuroscience letters 711, 134437 (2019). doi:10.1016/j.neulet.2019.134437
Neuroscience Letters

Highlights • Parkinson’s disease (PD) may have an environmental component involving toxin exposure. • Trichloroethylene (TCE) is a major environmental contaminant and can convert to the toxin TaClo. • We administered TCE and TaClo to wild typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c72fc6dc3fd8505e5e8d6afd86da507

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

Autor: Mollereau, B., Rzechorzek, N. M., Roussel, B. D., Sedru, M., Brink, D., Bailly-Maitre, B., Palladino, F., Medinas, D. B., Domingos, P. M., Hunot, S., Chandran, S., Birman, S., Baron, T., Vivien, D., Duarte, C. B., Ryoo, H. D., Steller, H., Urano, F., Chevet, E., Kroemer, G., Ciechanover, A., Calabrese, E. J., Kaufman, R. J., Hetz, C

Publikováno v: Brain Research
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. 〈10.1016/j.brainres.2016.02.033〉
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. ⟨10.1016/j.brainres.2016.02.033⟩
Mollereau, B, Rzechorzek, N M, Roussel, BD, Sedru, M, Van denBrink, D, Bailly-Maitre, B, Palladino, F, Medinas, DB, Domingos, PM, Hunot, S, Chandran, S, Birman, S, Baron, T, Vivien, D, Duarte, CB, Ryoo, HD, Steller, H, Urano, F, Chevet, E, Kroemer, G, Ciechanover, A, Calabrese, EJ, Kaufman, RJ & Hetz, C 2016, ' Adaptive preconditioning in neurological diseases-­ therapeutic insights from proteostatic perturbations ', Brain Research . https://doi.org/10.1016/j.brainres.2016.02.033

In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac2c955da4a10f0f472d98f9cd8189b5
http://europepmc.org/articles/PMC5010532

Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption

Autor: Pamela Lopert, Manisha Patel

Publikováno v: Redox Biology
Redox Biology, Vol 2, Iss C, Pp 667-672 (2014)

Mutations in the DJ-1 gene have been shown to cause a rare autosomal-recessive genetic form of Parkinson’s disease (PD). The function of DJ-1 and its role in PD development has been linked to multiple pathways, however its exact role in the develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a1a94e2d749607bdffffb692abaf3f
http://europepmc.org/articles/PMC4052521