Zobrazeno 1 - 10
of 112
pro vyhledávání: '"SNC-80"'
Autor:
Victoria L.C. Pallares, Anna E. Pennington, Morgan L. Crowley, Avi Patel, Morgan E. Reeves, Carolina Lopera-Londoño, Marco Mottinelli, Nicholas P. Ho, Francisco León, John D. Fortner, Christopher R. McCurdy, Luis F. Restrepo, Victoria A. Taylor, Jenny L. Wilkerson, Lance R. McMahon, Samuel Obeng, Takato Hiranita, Tobias Braun, Lea R. Gamez-Jimenez, Morgan R. Williamson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:410-427
Relationships between µ-opioid receptor (MOR) efficacy and effects of mitragynine and 7-hydroxymitragynine are not fully established. We assessed in vitro binding affinity and efficacy and discriminative stimulus effects together with antinociceptio
Autor:
Callaghan Ck, Karen Smith, Islam Mn, Shane M. O'Mara, Connie Sanchez, Rouine J, David J. Eyerman, Blumberg L
RationaleMany patients respond inadequately to antidepressant drug treatment; the search for alternate pharmacological treatment mechanisms is ongoing. Until the 1950’s, opium was sometimes used to treat depression, but eventually abandoned due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f89ffd8b983b3d69e3cc86f9d54c4b
Autor:
Agnieszka Sulima, Kenner C. Rice, Angela M. Lindsey, Phillip A. Saccone, James H. Woods, Kathy A. Zelenock, Eric P. Prinssen, Jürgen Wichmann
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 357:17-23
Nociceptin/orphanin FQ receptor (NOP) agonists have been reported to produce antinociceptive effects in rhesus monkeys with comparable efficacy to μ-opioid receptor (MOP) agonists, but without their limiting side effects. There are also known to be
Autor:
Gabriele Murineddu, Gian Luca Casu, Paolo Lazzari, Stefania Ruiu, Giovanni Loriga, Gérard Aimé Pinna, Ilaria Manca, Battistina Asproni, Giorgio Marchese, Christian Dessi
Publikováno v:
European journal of medicinal chemistry (Online) 69 (2013): 413–426. doi:10.1016/j.ejmech.2013.09.014
info:cnr-pdr/source/autori:Loriga G.; Lazzari P.; Ruiu S.; Marchese G.; Manca I.; Casu G.L.; Dessi C.; Pinna G.A.; Asproni B.; Murineddu G./titolo:Synthesis and biological evaluation of novel delta (?) opioid receptor ligands with diazatricyclodecane skeletons/doi:10.1016%2Fj.ejmech.2013.09.014/rivista:European journal of medicinal chemistry (Online)/anno:2013/pagina_da:413/pagina_a:426/intervallo_pagine:413–426/volume:69
info:cnr-pdr/source/autori:Loriga G.; Lazzari P.; Ruiu S.; Marchese G.; Manca I.; Casu G.L.; Dessi C.; Pinna G.A.; Asproni B.; Murineddu G./titolo:Synthesis and biological evaluation of novel delta (?) opioid receptor ligands with diazatricyclodecane skeletons/doi:10.1016%2Fj.ejmech.2013.09.014/rivista:European journal of medicinal chemistry (Online)/anno:2013/pagina_da:413/pagina_a:426/intervallo_pagine:413–426/volume:69
Considering the interesting pharmacological profile of the delta (?) selective opioid agonist compound SNC-80, conformationally constrained analogs containing two diazatricyclodecane ring systems in place of dimethylpiperazine core motif were synthes
Publikováno v:
The Journal of Pain. 6:261-274
Previous studies suggest that sex differences in morphine antinociception in rodents might be attributed to the activational effects of gonadal hormones. The present study determined whether hormonal modulation of opioid antinociception in adult rats
Publikováno v:
European Journal of Pharmacology. 511:207-217
We evaluated the anti-exudative effects (Evan's blue) of mu-, delta- and kappa-opioid receptor agonists in a rat model of carrageenan-induced acute inflammation. The contribution of different components was assessed after the administration of: cyclo
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Autor:
Coop A, Calderon Sn
Publikováno v:
Current Pharmaceutical Design. 10:733-742
The discovery of the selective delta (delta) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of delta-opioid ligands. Much research has been performed to unc
Autor:
Masano Sugiyama, Vanessa Grife, Marc Rubenzik, Eva V. Varga, Henry I. Yamamura, Victor J. Hruby, Kenner C. Rice, William R. Roeske, Dagmar Stropova
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:109-115
Adenylyl cyclase (AC) superactivation is thought to play an important role in opioid tolerance, dependence, and withdrawal. In the present study, we investigated the involvement of protein kinases in chronic delta-opioid agonist-mediated AC superacti