Zobrazeno 1 - 10
of 1 164
pro vyhledávání: '"SNAr"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 767-776 (2024)
A carboranylporphyrin of A3B-type bearing a single pentafluorophenyl ring was prepared through the regioselective nucleophilic aromatic substitution reaction of the p-fluorine atoms in 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin with 9-mercapto-m
Externí odkaz:
https://doaj.org/article/cb0f745a2a554eafa763f16ae9429298
Publikováno v:
Molbank, Vol 2024, Iss 3, p M1863 (2024)
In this study, we report the synthesis of 3-((2-(4-chloro-5-ethoxy-2-nitrophenoxy)acetamido)methyl)phenyl-dimethylcarbamate, designed on the basis of the structures of the commercial acetylcholinesterase inhibitor drug rivastigmine and a substituted
Externí odkaz:
https://doaj.org/article/63ec24ffac61462fb5ef8616726db71d
Autor:
Yan Wu, Ying Bei, Wenjing Li, Weihong Lu, Jian Zhu, Zhengbiao Zhang, Tinglin Zhang, Sen Liu, Kaiyuan Chen, Hong Jin, Luxin Li, Meng Li, Jie Gao, Xiangqiang Pan
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract Fabrication of versatile hydrogels in a facile and effective manner represents a pivotal challenge in the field of biomaterials. Herein, a novel strategy is presented for preparing on‐demand degradable hydrogels with multilevel responsiven
Externí odkaz:
https://doaj.org/article/c44bf7ee72f94b008e086d64b27ad8ac
Publikováno v:
Molecules, Vol 29, Iss 18, p 4322 (2024)
A synthesis of benzo[d]oxazoles by an N-deprotonation–O-SNAr cyclization sequence from anilide precursors is reported. Anilides derived from 2-fluorobenzaldehydes, activated toward SNAr ring closure by C5 electron-withdrawing groups, were prepared
Externí odkaz:
https://doaj.org/article/fb745a45552646928371123b377ce767
Publikováno v:
Molecules, Vol 29, Iss 14, p 3406 (2024)
A one-pot [3+3] aldol-SNAr-dehydration annulation sequence was utilized to fuse hindered phenols onto aromatic substrates. The transformation joins doubly activated 1,3-disubstituted acetone derivatives (dinucleophiles) with C5-activated 2-fluorobenz
Externí odkaz:
https://doaj.org/article/9588f2d2a91c486982656f405c87858f
Publikováno v:
Molbank, Vol 2024, Iss 1, p M1796 (2024)
The quinoline derivative, N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide, was synthesized in a conventional three-step procedure from 4,7-dichloroquinoline using a N-oxidation reaction/C2-amide formation reaction/C4 SNAr reaction sequence. The struc
Externí odkaz:
https://doaj.org/article/03cfee118e1a4140858c1b1ccf2a56c7
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101438- (2024)
The chemistry of chloroquinoxalines has garnered significant interest owing to the potential applications of this nitrogen-containing heterocyclic class in various fields. This manuscript delves into the investigation of heteroaromatic nucleophilic s
Externí odkaz:
https://doaj.org/article/03e568f5b2664733a704a041d3ce8863
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101389- (2024)
In this study, a new series of quinoxaline derivatives were synthesized by the reaction of 2,3-dichloroquinoxaline with aromatic thiols, leading to the formation of 2,3-bis(arylthiol)quinoxaline, 4-chloro-12H-quinoxalino[2,3-b]1,4-benzothiazine and 5
Externí odkaz:
https://doaj.org/article/7317e467e1b146468a847da251d17b0d
Autor:
Collin Zimmer, Jan Brauer, Dorota Ferenc, Jessica Meyr, Patrick Müller, Hans-Joachim Räder, Bernd Engels, Till Opatz, Tanja Schirmeister
Publikováno v:
Molecules, Vol 29, Iss 11, p 2660 (2024)
The aim of this study was to investigate the transition from non-covalent reversible over covalent reversible to covalent irreversible inhibition of cysteine proteases by making delicate structural changes to the warhead scaffold. To this end, dipept
Externí odkaz:
https://doaj.org/article/60ad1902ed054cbca788414b67730366
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