Integrated Systems Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveals a Tumor-Promoting Role for ST6GAL1

Autor: Emma Kurz, Emily A. Vucic, Gillian G. Baptiste, Shuhui Chen, Dafna Bar-Sagi, Praveen Agrawal, Cristina H. Hajdu, Lara K. Mahal, Cynthia Loomis

Publikováno v: Molecular & Cellular Proteomics : MCP

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. Glycans, such as carbohydrate antigen 19-9, are biomarkers of PDAC and are emerging as important modulators of cancer phenotypes. Herein, we used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241e8ac532a4e9ba5d413672f4db8d4b
https://doi.org/10.1016/j.mcpro.2021.100160

Carbohydrate-to-carbohydrate interactions between α2,3- linked sialic acids on α2 integrin subunits and asialo-GM1 underlie the bone metastatic behavior of LNCaP-derivative C4-2B prostate cancer cells

Autor: Marie-Ange Krzewinski-Recchi, Sophie Groux-Degroote, Séverine Van Slambrouck, Philippe Delannoy, Wim F.A. Steelant, Aurélie Cazet

Publikováno v: Bioscience Reports
Bioscience Reports, Portland Press, 2014, epub ahead of print. ⟨10.1042/BSR20140096⟩
Bioscience Reports, Vol 34, Iss 5, p e00138 (2014)
Bioscience Reports, 2014, epub ahead of print. ⟨10.1042/BSR20140096⟩

Complex interplays among proteins, lipids and carbohydrates can alter the phenotype and are suggested to have a crucial role in tumour metastasis. Our previous studies indicated that a complex of the GSLs (glycosphingolipids), AsGM1 (asialo-GM1), whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4474fc9be233389ca77d0758d443a200
https://hal.archives-ouvertes.fr/hal-01058160

Spatiotemporal changes of tissue glycans depending on localization in cardiac aging.

Autor: Itakura Y; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan., Hasegawa Y; Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan., Kikkawa Y; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.; Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan., Murakami Y; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.; Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan., Sugiura K; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.; Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan., Nagai-Okatani C; Cellular and Molecular Biotechnology Research Institute, National Institutes of Advanced Industrial Science and Technology, 5 Central, Tsukuba, 1-1-1 Higashi, Tsukuba-city, Ibaraki 305-8565, Japan., Sasaki N; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan., Umemura M; Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan., Takahashi Y; Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan., Kimura T; Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan., Kuno A; Cellular and Molecular Biotechnology Research Institute, National Institutes of Advanced Industrial Science and Technology, 5 Central, Tsukuba, 1-1-1 Higashi, Tsukuba-city, Ibaraki 305-8565, Japan., Ishiwata T; Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan., Toyoda M; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.

Publikováno v: Regenerative therapy [Regen Ther] 2023 Jan 07; Vol. 22, pp. 68-78. Date of Electronic Publication: 2023 Jan 07 (Print Publication: 2023).