Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

Autor: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1
https://doi.org/10.1016/j.apsb.2020.07.007

Biomechanical, histologic, and molecular characteristics of graft-tunnel healing in a murine modified ACL reconstruction model

Autor: Sai Yao, Fangda Fu, Peijian Tong, Hongting Jin, Taotao Xu, Hongfeng Ruan, Chengliang Wu, Huan Yu, Di Chen, Huan Luo

Publikováno v: Journal of Orthopaedic Translation, Vol 24, Iss, Pp 103-111 (2020)
Journal of Orthopaedic Translation

Summary Purpose The purpose of our study was to introduce and validate a metal-free, reproducible and reliable mouse model of anterior cruciate ligament (ACL) reconstruction (ACLR) surgery as an effective tool for a better understanding of molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be33b81f4d48c4bf41250e4fcc3ac8d
http://www.sciencedirect.com/science/article/pii/S2214031X2030070X

Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6Summary

Autor: Maureen Gannon, Peter A. Kropp, Xiaodong Zhu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 841-856 (2019)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims The Onecut 1 transcription factor (Oc1, a.k.a. HNF6) promotes differentiation of endocrine and duct cells of the pancreas; however, it has no known role in acinar cell differentiation. We sought to better understand the role of Oc1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8340f4db90d84f348eeb0763345455be
http://www.sciencedirect.com/science/article/pii/S2352345X19300207

Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor LesionsSummary

Autor: Juanita L. Merchant, Lin Ding

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 201-210 (2017)
Cellular and Molecular Gastroenterology and Hepatology

Since its initial discovery in Drosophila, Hedgehog (HH) signaling has long been associated with foregut development. The mammalian genome expresses 3 HH ligands, with sonic hedgehog (SHH) levels highest in the mucosa of the embryonic foregut. More r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e077df2ac4c1cce99125281189ce77f3
http://www.sciencedirect.com/science/article/pii/S2352345X17300085

The immune landscape of chondrosarcoma reveals an immunosuppressive environment in the dedifferentiated subtypes and exposes CSFR1+ macrophages as a promising therapeutic target

Autor: Iseulys, Richert, Anne, Gomez-Brouchet, Corinne, Bouvier, Gonzague, Du Bouexic De Pinieux, Marie, Karanian, Jean-Yves, Blay, Aurélie, Dutour

Publikováno v: Journal of Bone Oncology

Survival rate for Chondrosarcoma (CHS) is at a standstill, more effective treatments are urgently needed. Consequently, a better understanding of CHS biology and its immune environment is crucial to identify new prognostic factors and therapeutic tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::137809745bf56c1f8a4c5dca101c9a7b
https://pubmed.ncbi.nlm.nih.gov/32274326