Zobrazeno 1 - 10
of 140
pro vyhledávání: '"SMG1"'
Autor:
Alexander C. Leeksma, Ingrid A. M. Derks, Brett Garrick, Aldo Jongejan, Martino Colombo, Timon Bloedjes, Torsten Trowe, Jim C. Leisten, Michelle Howarth, Mehnaz Malek, Deborah S. Mortensen, Kate Blease, Mathew C. Groza, Rama Krishna Narla, Remco Loos, Marie‐José Kersten, Perry D. Moerland, Jeroen E. J. Guikema, Arnon P. Kater, Eric Eldering, Ellen H. Filvaroff
Publikováno v:
Molecular Oncology, Vol 17, Iss 2, Pp 284-297 (2023)
Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein kinase (DNA‐PK) may have additional targets beyond TORK and DNA‐PK. Therefore, we aimed
Externí odkaz:
https://doaj.org/article/702d5efc32b54942a82e101ab9e8166c
Publikováno v:
Cell Journal, Vol 24, Iss 12, Pp 757-763 (2022)
Objective Chronic myeloid leukemia (CML) is a myeloproliferative malignancy with different stages. Aberrant epigeneticmodifications, such as DNA methylation, have been introduced as a signature for diverse cancers which also plays acrucial role in CM
Externí odkaz:
https://doaj.org/article/45489a85c3334a6f89089f5d4432642d
Autor:
Sifan Sun, Hailiang Fang
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Background Curcumin has a potential therapeutic role in ovarian cancer. However, whether curcumin plays anti-cancer role in ovarian cancer by mediating the circular RNA (circRNA)/microRNA (miRNA)/mRNA network is still unclear. Methods The ex
Externí odkaz:
https://doaj.org/article/822a862c350047b3990faeb441b5e6b1
Publikováno v:
Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-12 (2021)
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is the 6th most common malignant cancer type worldwide. Radiosensitivity has been shown to be significantly increased in patients with human papillomavirus (HPV)-positive HNSCC compare
Externí odkaz:
https://doaj.org/article/f82ea71ed2904ddeb1fcacb05e7e472a
Publikováno v:
Foods, Vol 11, Iss 24, p 4069 (2022)
Diacylglycerols (DAGs) display huge application prospectives in food industries. Therefore, new strategies to produce diacylglycerides are needed. Malassezia globose lipase (SMG1) could be used to synthesize DAGs. However, the poor thermostability of
Externí odkaz:
https://doaj.org/article/bb48b68fbc704d3abc6077138a09a0ac
Autor:
Feifan Wang, Yan Zhang, Xuejian Zhou, Xianwu Chen, Jiayong Xiang, Mengjing Fan, Yanlan Yu, Yueshu Cai, Hongshen Wu, Shihan Huang, Ning He, Zhenghui Hu, Guoqing Ding, Xiaodong Jin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Circular RNA (circRNA) is a newly discovered endogenous non-coding RNA (ncRNA), which is characterized with a closed circular structure. A growing body of evidence has verified the vital roles of circRNAs in human cancer. In this research, we selecte
Externí odkaz:
https://doaj.org/article/b01f027e282344da995aad4e7ddae4c5
Akademický článek
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Publikováno v:
Data in Brief, Vol 33, Iss , Pp 106602- (2020)
Nonsense-mediated mRNA decay (NMD) is a system that controls the quality of mRNA transcripts in eukaryotes by degradation of aberrant transcripts in a pioneer round of translation. In mammals, NMD targets one-third of mutated, disease-causing mRNAs a
Externí odkaz:
https://doaj.org/article/5d6dd54ca5a644b1a6e50ba99f1d7296
Autor:
Alexander C. Leeksma, Ingrid A. M. Derks, Brett Garrick, Aldo Jongejan, Martino Colombo, Timon Bloedjes, Torsten Trowe, Jim C. Leisten, Michelle Howarth, Mehnaz Malek, Deborah S. Mortensen, Kate Blease, Mathew C. Groza, Rama Krishna Narla, Remco Loos, Marie‐José Kersten, Perry D. Moerland, Jeroen E. J. Guikema, Arnon P. Kater, Eric Eldering, Ellen H. Filvaroff
Publikováno v:
Molecular oncology. Elsevier
Leeksma, A C, Derks, I A M, Garrick, B, Jongejan, A, Colombo, M, Bloedjes, T, Trowe, T, Leisten, J C, Howarth, M, Malek, M, Mortensen, D S, Blease, K, Groza, M C, Narla, R K, Loos, R, Kersten, M-J, Moerland, P D, Guikema, J E J, Kater, A P, Eldering, E & Filvaroff, E H 2022, ' SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma ', Molecular oncology . https://doi.org/10.1002/1878-0261.13343
Leeksma, A C, Derks, I A M, Garrick, B, Jongejan, A, Colombo, M, Bloedjes, T, Trowe, T, Leisten, J C, Howarth, M, Malek, M, Mortensen, D S, Blease, K, Groza, M C, Narla, R K, Loos, R, Kersten, M-J, Moerland, P D, Guikema, J E J, Kater, A P, Eldering, E & Filvaroff, E H 2022, ' SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma ', Molecular oncology . https://doi.org/10.1002/1878-0261.13343
Early data suggested that CC-115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA-dependent protein kinase (DNA-PK) may have additional targets beyond TORK and DNA-PK. Therefore, we aimed to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc34b2dab0571f6f622996e577edf883
https://doi.org/10.1002/1878-0261.13343
https://doi.org/10.1002/1878-0261.13343
Autor:
Angel Rivera-Calzada, Andrés López-Perrote, Roberto Melero, Jasminka Boskovic, Hugo Muñoz-Hernández, Fabrizio Martino, Oscar Llorca
Publikováno v:
AIMS Biophysics, Vol 2, Iss 2, Pp 36-57 (2015)
The phosphatidylinositol 3-kinase-like kinases (PIKKs) are large serine-threonine protein kinases with a catalytic domain homologous to the phosphatidylinositol 3-kinase (PI3K). All PIKK family members share a general organization comprising a conser
Externí odkaz:
https://doaj.org/article/55180b8d8ddd46cea18153fcf849b73b