Zobrazeno 1 - 10
of 28
pro vyhledávání: '"SMCs, smooth muscle cells"'
Autor:
Ariane Schumski, Quinte Braster, Oliver Soehnlein, Gerry A. F. Nicolaes, Carlos Silvestre-Roig, Kanin Wichapong
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 934-948 (2021)
Computational and Structural Biotechnology Journal, 19, 934-948. Research Network of Computational and Structural Biotechnology
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 934-948 (2021)
Computational and Structural Biotechnology Journal, 19, 934-948. Research Network of Computational and Structural Biotechnology
Graphical abstract
Highlights • Intrinsically disordered proteins/protein regions (IDPs/IDPRs) are emerging drug targets. • Lack of fast methods hinders the discovery of inhibitors for IDPs/ IDPRs. • Fast and inexpensive structure-based ap
Highlights • Intrinsically disordered proteins/protein regions (IDPs/IDPRs) are emerging drug targets. • Lack of fast methods hinders the discovery of inhibitors for IDPs/ IDPRs. • Fast and inexpensive structure-based ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c60400bc45a465a5727e13acdbffb5
http://europepmc.org/articles/PMC7856395
http://europepmc.org/articles/PMC7856395
Publikováno v:
Journal of Advanced Research, Vol 26, Iss, Pp 123-135 (2020)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract The map illustrating mechanisms associated with lncRNA HIF1A-AS2-mediated inflammation in the atherosclerosis. LncRNA HIF1A-AS2 forms a complex with USF1, which is recruited into the ATF2 promoter to elevate ATF2 expression, thus p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47972e7d0a5a67e00cdb998231298698
http://www.sciencedirect.com/science/article/pii/S2090123220301740
http://www.sciencedirect.com/science/article/pii/S2090123220301740
Autor:
Manuela Viola, Davide Vigetti, Paola Moretto, Evgenia Karousou, Alberto Passi, Ilaria Caon, Arianna Parnigoni
Publikováno v:
Matrix Biology Plus
Matrix Biology Plus, Vol 11, Iss, Pp 100060-(2021)
Matrix Biology Plus, Vol 11, Iss, Pp 100060-(2021)
In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival. Three different isoforms of HA synthases (HAS1, 2, and 3) are responsible for the prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b11cc44a8141b5c204d5fea01a8913
http://europepmc.org/articles/PMC8377009
http://europepmc.org/articles/PMC8377009
Autor:
Jay L. Zweier, Mohamed A. El-Mahdy, Tapan Kumar Kundu, Sahar A. Khaleel, Craig Hemann, Govindasamy Ilangovan
Publikováno v:
The Journal of Biological Chemistry
In smooth muscle, cytoglobin (Cygb) functions as a potent nitric oxide (NO) dioxygenase and regulates NO metabolism and vascular tone. Major questions remain regarding which cellular reducing systems regulate Cygb-mediated NO metabolism. To better de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402d29350bd511c71de9574951fdf260
http://europepmc.org/articles/PMC7948950
http://europepmc.org/articles/PMC7948950
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1261-1273 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1261-1273 (2021)
Neointimal hyperplasia after vascular injury is a representative complication of restenosis. Endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) is involved in the pathogenesis of vascular intimal hyperplasia. PARP16, a member o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3676f4e767ed13ecee8819ada7d766c
https://pubmed.ncbi.nlm.nih.gov/34094832
https://pubmed.ncbi.nlm.nih.gov/34094832
Publikováno v:
Redox Biology, Vol 32, Iss, Pp-(2020)
Redox Biology
Redox Biology
Recent cardiovascular outcome trials found that sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce cardiovascular disease and mortality in type 2 diabetic patients; however, the underlying mechanisms are not fully known. Since the proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a102648fade686c94ccceabb7ce99e6
http://www.sciencedirect.com/science/article/pii/S2213231720302147
http://www.sciencedirect.com/science/article/pii/S2213231720302147
Autor:
Monica Raicu, Maya Simionescu, Mihaela-Loredana Antonescu, Ioana Madalina Fenyo, Simona-Adriana Manea, Adrian Manea
Publikováno v:
Redox Biology
Redox Biology, Vol 16, Iss, Pp 332-343 (2018)
Redox Biology, Vol 16, Iss, Pp 332-343 (2018)
Reactive oxygen species (ROS) generated by up-regulated NADPH oxidase (Nox) contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulators of gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78bd5bc3b6c199e70a5e710bd225dcc
https://doi.org/10.1016/j.redox.2018.03.011
https://doi.org/10.1016/j.redox.2018.03.011
Autor:
Paola Gamba, Huveyda Basaga, Simona Gargiulo, Beyza Vurusaner, Gabriella Testa, Gabriella Leonarduzzi, Giuseppe Poli
Publikováno v:
Redox Biology
Redox Biology, Vol 17, Iss, Pp 400-410 (2018)
Redox Biology, Vol 17, Iss, Pp 400-410 (2018)
Autophagy has been shown to be stimulated in advanced atherosclerotic plaques by metabolic stress, inflammation and oxidized lipids. The lack of published studies addressing the potential stimulation of pro-survival autophagy by oxysterols, a family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cf20d20a8441ccaffe35b2c7968493
http://europepmc.org/articles/PMC5986166
http://europepmc.org/articles/PMC5986166
Autor:
Michael A. Rieger, Mario Looso, Norbert Weissmann, Maria Walter, Franziska Moll, Peter P. Nawroth, Valeska Helfinger, Fabian Hahner, Flávia Rezende, Patrick Janetzko, Ingrid Fleming, Katrin Schröder, Christian Ringel, Ralf P. Brandes, Thomas Fleming, Andreas Weigert, Carsten Kuenne
Publikováno v:
Redox Biol. 15, 12-21 (2018)
Redox Biology, Vol 15, Iss C, Pp 12-21 (2018)
Redox Biology
Redox Biology, Vol 15, Iss C, Pp 12-21 (2018)
Redox Biology
Aim NADPH oxidases are important sources of reactive oxygen species (ROS). Several Nox homologues are present together in the vascular system but whether they exhibit crosstalk at the activity level is unknown. To address this, vessel function of kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a2b66fb96b704096740836bd937bf3
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52450
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52450
Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Autor:
Ramji, Dipak P., Davies, Thomas S.
Publikováno v:
Cytokine & Growth Factor Reviews
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most deaths in westernized societies with numbers increasing at a marked rate in developing countries. The disease is initiated by the activation of the endothelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d1983b7d9f08e9a781930cb08b716481