Zobrazeno 1 - 10
of 228
pro vyhledávání: '"SMAD binding"'
Publikováno v:
Molecular Medicine Reports
The exact mechanisms underlying hypertrophic scarring is yet to be fully understood. However, excessive collagen deposition by fibroblasts has been demonstrated to result in hypertrophic scar formation, and collagen synthesis in dermal fibroblasts is
Autor:
Eijiro Jimi, Shizu Hirata-Tsuchiya, Noriko Saito, Hideki Shiba, Satoru Yamada, Shigeki Suzuki, Chiaki Kitamura, Hang Yuan, Kazuki Okamoto
Publikováno v:
Molecular and Cellular Biochemistry. 469:133-142
Pro-inflammatory cytokines prevent bone regeneration in vivo and activation of nuclear factor-κB (NF-κB) signaling has been proposed to lead to suppression of bone morphogenetic protein (BMP)-induced osteogenesis via direct binding of p65 to Smad4
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 2, Pp 195-210 (2020)
Background/aims Idiopathic pulmonary fibrosis (IPF) is a specific form of progressive and chronic interstitial lung disease of unknown cause. IPF is characterized by excessive deposition of extracellular matrix (ECM) and destructive pathological remo
Autor:
Kohei Miyazono, Tomohiro Ogami, Mitsuyoshi Motizuki, Hiroyuki Aburatani, Yuka Itoh, Chiho Omata, Masao Saitoh, Kunio Miyake, Daizo Koinuma, Shuichi Tsutsumi, Takuma Itoh, Keiji Miyazawa, So-ichi Yaguchi
Publikováno v:
J Biol Chem
Smad proteins are transcriptional regulators activated by TGF-β. They are known to bind to two distinct Smad-responsive motifs, namely the Smad-binding element (SBE) (5′-GTCTAGAC-3′) and CAGA motifs (5′-AGCCAGACA-3′ or 5′-TGTCTGGCT-3′).
Autor:
Pamela L. Mellon, Jessica Cassin, Varykina G. Thackray, Stephanie C Bohaczuk, Theresa I Slaiwa
Publikováno v:
Endocrinology
FSH is critical for fertility. Transcription of FSHB, the gene encoding the beta subunit, is rate-limiting in FSH production and is regulated by both GnRH and activin. Activin signals through SMAD transcription factors. Although the mechanisms and im
Developmental control of jaw length is critical for survival. The jaw skeleton arises from neural crest mesenchyme and previously we demonstrated that these progenitors upregulate bone-resorbing enzymes includingMatrix metalloproteinase 13(Mmp13)when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36401ca2e3338fd4e446e1cee52f0e34
https://doi.org/10.1101/2020.12.23.424223
https://doi.org/10.1101/2020.12.23.424223
Autor:
Suena Ji, Min Jueng Kang, Yeon Jung Kim, Jin Won Cho, Eugene C. Yi, Yun Soo Park, Won Ho Yang, Tae Hyun Kweon, Eunah Kim
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification which occurs on the hydroxyl group of serine or threonine residues of nucleocytoplasmic proteins. It has been reported that the presence of this single sugar motif regula
Autor:
Sun Woo Jin, Young Chul Chung, Hye Gwang Jeong, Jae Ho Choi, Hyun Sun Lee, Gi Ho Lee, Seul Mi Kim
Publikováno v:
Cells
Volume 8
Issue 12
Volume 8
Issue 12
Platycodi radix is a widely sold health food worldwide, which contains numerous phytochemicals that are beneficial to health. Previously, we reported that saponin from the roots of Platycodi radix-derived saponin inhibited toxicant-induced liver dise
Autor:
Saeede Yavari, Monireh Malekpour, Zahra Zare, Azadeh Safaeian, Tina Nayerpour dizaj, Parisa Khanicheragh, Hasan Nejadbiglari, Mohammad Panji, Maryam Shabanzadeh, Mojtaba Abbasi, Narges Maleki, Omid Abazari, Vahideh Behmard
Publikováno v:
Gene. 794:145774
Transforming growth factor-β (TGF-β)-induced Epithelial-to-mesenchymal transition (EMT) process is a fundamental target for preventing cervical cancer cells' progression and invasion. Green tea and its principal active substance, Epigallocatechin-3
Publikováno v:
Biochemical Journal. 474:1531-1546
Transforming growth factor β (TGF-β) contributes to wound healing and, when dysregulated, to pathological fibrosis. TGF-β and the anti-fibrotic nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ) repress each other's ex