Zobrazeno 1 - 10
of 385
pro vyhledávání: '"SMAC mimetic"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Death receptor (DR) networks are controlled by the assembly of the Death-Inducing Signaling Complex (DISC) and complex II. The family of small molecules FLIPins (FLIP interactors) were developed to target the caspase-8/c-FLIPL heterodimer. FLIPin com
Externí odkaz:
https://doaj.org/article/7aeed166e38d48c38f7c53462df12fb6
Autor:
Wentao Pan, Qiuyun Luo, Eric Liang, Mude Shi, Jian Sun, Huimin Shen, Zhenhai Lu, Lin Zhang, Xianglei Yan, Luping Yuan, Suna Zhou, Hanjie Yi, Yifan Zhai, Miao-zhen Qiu, Dajun Yang
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Immune checkpoint inhibitors are approved for the treatment of various tumors, but the response rate is not satisfactory in certain malignancies. Inhibitor of apoptosis proteins (IAP) ubiquitin-E3 ligase activity is involved in th
Externí odkaz:
https://doaj.org/article/351b402f688449ceb4c6ca9f401e8dfc
Akademický článek
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Autor:
Vikash Kansal, Brendan L. C. Kinney, Srijayaprakash Uppada, Nabil F. Saba, William A. Stokes, Zachary S. Buchwald, Nicole C. Schmitt
Publikováno v:
Cancer Medicine, Vol 12, Iss 13, Pp 13958-13965 (2023)
Abstract Inhibitors of apoptosis proteins (IAPs) inhibit the intrinsic and extrinsic cell death pathways, promoting cell survival. Antagonists of these pathways are under study as anti‐cancer therapeutics. A high proportion of head and neck squamou
Externí odkaz:
https://doaj.org/article/b0c759795a2b40de967a38d3dd103122
Autor:
Jin Koo Kim, Insoon Chang, Younghun Jung, Zach Kaplan, Elliott E. Hill, Russell S. Taichman, Paul H. Krebsbach
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20655- (2023)
Growing evidence suggests an association between Mycoplasma infections and the development and progression of prostate cancer (PCa). In this study, we report that chronic and persistent M. hyorhinis infection induced robust TNF-α secretion from PCa
Externí odkaz:
https://doaj.org/article/4f4e06b48a8f41b6bd2e90617bc026f1
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 10, Pp 4803-4821 (2022)
Smac mimetics are a group of compounds able to facilitate cell death in cancer cells. TNF-related apoptosis-inducing ligand (TRAIL) is a death receptor ligand currently explored in combination with Smac mimetics. The molecular mechanisms determining
Externí odkaz:
https://doaj.org/article/2370a8b21a8142a89caaa340af35d919
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15405 (2023)
Defects in cell death signaling pathways are one of the hallmarks of cancer and can lead to resistance to conventional therapy. Natural products are promising compounds that can overcome this resistance. In the present study we studied the effect of
Externí odkaz:
https://doaj.org/article/0a743fc67f2940a09e0ebd4526ac5af6
Akademický článek
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Autor:
Irfan Ahmad, Safia Irfan, Mirza Masroor Ali Beg, Hosam Kamli, Syed Parveen Ali, Naseem Begum, Mohammad Alshahrani, Prasanna Rajagopalan
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 24, Iss 7, Pp 969-977 (2021)
Objective(s): The Inhibitors of Apoptosis (IAPs) regulate initiator and effector phases of caspase mediated apoptosis. This study evaluates the effects of SMAC mimetic AT-101 in regulation of IAPs/caspases/NFƙB-p65 in an adenocarcinoma cell line.Mat
Externí odkaz:
https://doaj.org/article/7162834f7919432f86f7ae61ed0135e8
Autor:
Gertrud Knoll, Martin Ehrenschwender
Publikováno v:
FEBS Open Bio, Vol 11, Iss 3, Pp 714-723 (2021)
Apoptosis resistance worsens treatment response in cancer and is associated with poor prognosis. Inhibition of anti‐apoptotic proteins can restore cell death and improve treatment efficacy. cIAP1, cIAP2, and XIAP belong to the inhibitor of apoptosi
Externí odkaz:
https://doaj.org/article/27a24602cda5431ba6b1e64a90763e27