Empirically establishing drug exposure records directly from untargeted metabolomics data.

Autor: Zhao HN; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Kvitne KE; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Department of Pharmacy, University of Oslo, Oslo, Norway., Brungs C; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Mohan S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Charron-Lamoureux V; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Bittremieux W; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Department of Computer Science, University of Antwerp, Antwerp, Belgium., Tang R; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Schmid R; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Lamichhane S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Tykistönkatu 6A, 20520 Turku, Finland., El Abiead Y; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Andalibi MS; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; HIV Neurobehavioral Research Program, University of California San Diego, La Jolla, CA, USA., Mannochio-Russo H; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Ambre M; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Avalon NE; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA., Bryant M; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Caraballo-Rodríguez AM; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Maya MC; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Chin L; Department of Bioengineering, University of California San Diego, La Jolla, California, USA., Ellis RJ; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Franklin D; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Girod S; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada., Gomes PWP; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Faculty of Chemistry, Federal University of Para, Belem, PA, Brazil., Hansen L; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Heaton R; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Iudicello JE; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Jarmusch AK; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Khatib L; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Letendre S; HIV Neurobehavioral Research Program, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Magyari S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., McDonald D; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Mohanty I; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Cumsille A; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Department of Microbiology and Cell Sciences, University of Florida, Museum Drive, Gainesville, FL, USA., Moore DJ; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; HIV Neurobehavioral Research Program, University of California San Diego, La Jolla, CA, USA., Rajkumar P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Ross DH; Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA.; Current address: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Sapre H; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Shahneh MRZ; Department of Computer Science and Engineering, University of California Riverside, Riverside, CA, USA., Thomas SP; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Tribelhorn C; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Tubb HM; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Walker C; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Wang CX; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; HIV Neurobehavioral Research Program, University of California San Diego, La Jolla, CA, USA., Xing S; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Zemlin J; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA., Zuffa S; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Wishart DS; Department of Bioengineering, University of California San Diego, La Jolla, California, USA.; Department of Computing Science, University of Alberta, Edmonton, AB T6G 2E8, Canada., Kaddurah-Daouk R; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, 27708, USA.; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA.; Department of Medicine, Duke University, Durham, NC, USA., Wang M; Department of Computer Science and Engineering, University of California Riverside, Riverside, CA, USA., Raffatellu M; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.; Chiba University, UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA, USA., Zengler K; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.; Program in Materials Science and Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0418, USA., Pluskal T; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Xu L; Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA., Knight R; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.; Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Halicioğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA., Tsunoda SM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Dorrestein PC; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 26. Date of Electronic Publication: 2024 Oct 26.

Lower doses of carvedilol in Japanese heart failure patients with reduced ejection fraction could show the potential to be non-inferior to higher doses in US patients: An international collaborative observational study.

Autor: Maeda M; Laboratory of Clinical Pharmacology, Department of Pharmaceutical Sciences, Osaka University, Osaka, Japan.; Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan.; Department of Molecular Pharmaceutical Science, Graduate School of Medicine, Osaka University, Osaka, Japan., Humber D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, United States of America.; San Diego Health, University of California San Diego, San Diego, CA, United States of America., Hida E; Department of Biostatistics and Data Science, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan., Ohtani T; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan., Wang G; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, United States of America., Wu T; Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan., Takeda S; Laboratory of Clinical Pharmacology, Department of Pharmaceutical Sciences, Osaka University, Osaka, Japan., Situ JN; Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan., Hayashi J; Laboratory of Clinical Pharmacology, Department of Pharmaceutical Sciences, Osaka University, Osaka, Japan., Nonen S; School of Pharmacy, Hyogo Medical University, Hyogo, Japan., Takeda T; Department of Medical Informatics, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan., Okamoto H; Aishin-Memorial Hospital, Sapporo, Japan., Hori M; National Hospital Organization Osaka National Hospital, Osaka, Japan., Sakata Y; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan., Fujio Y; Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan., Tsunoda SM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, United States of America.; San Diego Health, University of California San Diego, San Diego, CA, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Mar 07; Vol. 19 (3), pp. e0299510. Date of Electronic Publication: 2024 Mar 07 (Print Publication: 2024).

An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant.

Autor: Thomas S; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, UC San Diego, La Jolla, California, USA., Gauglitz JM; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, UC San Diego, La Jolla, California, USA., Tripathi A; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, UC San Diego, La Jolla, California, USA., Vargas F; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, UC San Diego, La Jolla, California, USA., Bertrand K; Division of Dysmorphology and Teratology, Department of Pediatrics, UC San Diego, La Jolla, California, USA., Kim JH; Department of Pediatrics, Perinatal Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Chambers C; Division of Dysmorphology and Teratology, Department of Pediatrics, UC San Diego, La Jolla, California, USA., Dorrestein PC; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, UC San Diego, La Jolla, California, USA., Tsunoda SM; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2022 Nov; Vol. 15 (11), pp. 2576-2582. Date of Electronic Publication: 2022 Sep 12.

Physicochemical properties determining drug detection in skin.

Autor: Bittremieux W; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, California, USA.; Department of Computer Science, University of Antwerp, Antwerpen, Belgium., Advani RS; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, California, USA.; Department of Chemistry, University of Massachusetts-Amherst, Amherst, Massachusetts, USA., Jarmusch AK; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, California, USA.; Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA., Aguirre S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, California, USA., Lu A; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, California, USA., Dorrestein PC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.; Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, California, USA., Tsunoda SM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2022 Mar; Vol. 15 (3), pp. 761-770. Date of Electronic Publication: 2021 Nov 28.

Contribution of the Gut Microbiome to Drug Disposition, Pharmacokinetic and Pharmacodynamic Variability.

Autor: Tsunoda SM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, San Diego, CA, 90293-0657, USA. smtsunoda@health.ucsd.edu., Gonzales C; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, San Diego, CA, 90293-0657, USA., Jarmusch AK; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, San Diego, CA, 90293-0657, USA.; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, San Diego, CA, USA., Momper JD; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, San Diego, CA, 90293-0657, USA., Ma JD; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, San Diego, CA, 90293-0657, USA.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2021 Aug; Vol. 60 (8), pp. 971-984. Date of Electronic Publication: 2021 May 07.