Zobrazeno 1 - 10
of 587
pro vyhledávání: '"SLC30A8"'
Autor:
Md. Moin Uddin, Md. Tanvir Hossain, Md. Arju Hossain, Asif Ahsan, Kamrul Hasan Shamim, Md. Arif Hossen, Md. Shahinur Rahman, Md Habibur Rahman, Kawsar Ahmed, Francis M. Bui, Fahad Ahmed Al-Zahrani
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37280- (2024)
Background and aims: The single nucleotide polymorphisms (SNPs) in SLC30A8 gene have been recognized as contributing to type 2 diabetes (T2D) susceptibility and colorectal cancer. This study aims to predict the structural stability, and functional im
Externí odkaz:
https://doaj.org/article/9c6ee84657854cf6b643038131e12cc3
Autor:
Shafayater Nur Nadia, Md. Hasib, Imrul Hasan, Abdullah Al Saba, Mohammad Sayem, Akio Ebihara, A.K.M. Mahbub Hasan, A.H.M. Nurun Nabi
Publikováno v:
Endocrine and Metabolic Science, Vol 16, Iss , Pp 100189- (2024)
Zinc transporter ZnT8, encoded by SLC30A8, is expressed highly in pancreatic β-cells that effluxes Zn2+ into insulin granules which is required to secret insulin from the granules. Genome-wide association study identified twelve loss of function mut
Externí odkaz:
https://doaj.org/article/d684d5876d294c78aa6978a78773e0ba
Autor:
Lucia Azzollini, Dolores Del Prete, Gernot Wolf, Christoph Klimek, Mattia Saggioro, Fernanda Ricci, Eirini Christodoulaki, Tabea Wiedmer, Alvaro Ingles-Prieto, Giulio Superti-Furga, Lia Scarabottolo
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100166- (2024)
Zinc is an essential trace element that is involved in many biological processes and in cellular homeostasis. In pancreatic β-cells, zinc is crucial for the synthesis, processing, and secretion of insulin, which plays a key role in glucose homeostas
Externí odkaz:
https://doaj.org/article/b2fa08c76d0344f2a94893954e294f90
Autor:
Farhana Siddiqi Mitu, Md. Murad Hossain, Shuvo Chandra Das, Md. Mafizul Islam, Dhirendra Nath Barman, Shipan Das Gupta
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Type 2 diabetes mellitus (T2DM) is considered to be a polygenic disorder that emerges as a result of complicated gene-environment interactions. Several investigations revealed that SLC30A8 rs13266634 polymorphism elevates T2DM ris
Externí odkaz:
https://doaj.org/article/5ce4b3c1764a4392b6cded2b5d4cabf6
Akademický článek
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Autor:
George Firth, Eleni Georgiadou, Alexander Griffiths, Maral Amrahli, Jana Kim, Zilin Yu, Ming Hu, Theodora J. Stewart, Isabelle Leclerc, Haruka Okamoto, Daniel Gomez, Philip J. Blower, Guy A. Rutter
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionCommon variants in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8 (expressed largely in pancreatic islet alpha and beta cells), are associated with altered risk of type 2 diabetes. Unexpectedly, rare loss-of-functi
Externí odkaz:
https://doaj.org/article/75ed93d9f1f64c898d27e6bd1f975e33
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
E. S. Mel’nikova, S. V. Mustafina, O. D. Rymar, A. A. Ivanova, L. V. Shcherbakova, M. Bobak, S. K. Maljutina, M. I. Voevoda, V. N. Maksimov
Publikováno v:
Сахарный диабет, Vol 25, Iss 3, Pp 215-225 (2022)
BACKGROUND: The prevalence of Type 2 diabetes mellitus (T2DM) has reached epidemic proportions and it is estimated to affect over 400 million people worldwide. Moreover, the incidence of diabetes is expected to continue to rise and it is projected to
Externí odkaz:
https://doaj.org/article/3debac1b93c446eb96f4319e75a074ad
Publikováno v:
AIMS Molecular Science, Vol 8, Iss 4, Pp 301-310 (2021)
Objective: The aim of the current study was to explore the gene enrichment and dysregulated pathways on the basis of interaction network analysis of SLC30A8 in type 1 diabetes mellitus (T1DM). SLC30A8 polymorphism could be characterized as a benefic
Externí odkaz:
https://doaj.org/article/de57a00ac6c347bfa5e4094f6622e63b