Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1

Autor: Palanivel Kandasamy, Inti Zlobec, Damian T. Nydegger, Jonai Pujol‐Giménez, Rajesh Bhardwaj, Senji Shirasawa, Toshiyuki Tsunoda, Matthias A. Hediger

Publikováno v: Molecular Oncology, Vol 15, Iss 10, Pp 2782-2800 (2021)

Oncogenic KRAS mutations develop unique metabolic dependencies on nutrients to support tumor metabolism and cell proliferation. In particular, KRAS mutant cancer cells exploit amino acids (AAs) such as glutamine and leucine, to accelerate energy meta

Externí odkaz: https://doaj.org/article/b6fc7ae16925449f8d9d9da78bd65412

Amino acid transporters on the guard of cell genome and epigenome

Autor: Uğur, Kahya, Ayşe Sedef, Köseer, Anna, Dubrovska

Publikováno v: Cancers 13(2021)1, 125
Cancers, Vol 13, Iss 125, p 125 (2021)
Cancers

Simple Summary Amino acid transporters play a multifaceted role in tumor initiation, progression, and therapy resistance. They are critical to cover the high energetic and biosynthetic needs of fast-growing tumors associated with increased proliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac95c08f61276814d114f2c6556f044e
https://www.hzdr.de/publications/Publ-31791-1

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Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma.

Autor: Du D; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Liu C; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Qin M; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Zhang X; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Xi T; Research Center of Biotechnology, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China., Yuan S; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China., Hao H; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China., Xiong J; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2022 Feb; Vol. 12 (2), pp. 558-580. Date of Electronic Publication: 2021 Sep 25.