Zobrazeno 1 - 10
of 99
pro vyhledávání: '"SLC14A2"'
Autor:
T. V. Ivanenko
Publikováno v:
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Vol 16, Iss 2, Pp 154-157 (2023)
The development and progression of diabetes involves several molecular mechanisms, in particular: insulin resistance, dysfunction of beta cells, inflammatory processes. These mechanisms can disrupt insulin signaling pathways, contribute to beta-cell
Externí odkaz:
https://doaj.org/article/55949bf2ce74470db160234546374e90
Publikováno v:
Current issues in pharmacy and medicine: science and practice; Vol. 16 No. 2 (2023); 154-157
Актуальные вопросы фармацевтической и медицинской науки и практики; Том 16 № 2 (2023); 154-157
Актуальні питання фармацевтичної і медичної науки та практики; Том 16 № 2 (2023); 154-157
Актуальные вопросы фармацевтической и медицинской науки и практики; Том 16 № 2 (2023); 154-157
Актуальні питання фармацевтичної і медичної науки та практики; Том 16 № 2 (2023); 154-157
The development and progression of diabetes involves several molecular mechanisms, in particular: insulin resistance, dysfunction of beta cells, inflammatory processes. These mechanisms can disrupt insulin signaling pathways, contribute to beta-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=scientific_p::e5559513c83998b66347ce3c8885ccef
http://pharmed.zsmu.edu.ua/article/view/281209
http://pharmed.zsmu.edu.ua/article/view/281209
Publikováno v:
J Am Soc Nephrol
Background The repertoire of protein expression along the renal tubule depends both on regulation of transcription and regulation of alternative splicing that can generate multiple proteins from a single gene. Methods A full-length, small-sample RNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1eea2f60858de6e6eda462ba9b697da
https://pubmed.ncbi.nlm.nih.gov/33769951
https://pubmed.ncbi.nlm.nih.gov/33769951
Autor:
Craig N. Johnson, Atsuko Y. Higashi, Abdul Soofi, Sanjeevkumar R. Patel, Gregory R. Dressler, Saji Abraham, Ann M. Laszczyk
Publikováno v:
J Am Soc Nephrol
Background As the glomerular filtrate passes through the nephron and into the renal medulla, electrolytes, water, and urea are reabsorbed through the concerted actions of solute carrier channels and aquaporins at various positions along the nephron a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52dfab62cb7bb969e08029d97bae45b
https://pubmed.ncbi.nlm.nih.gov/32381599
https://pubmed.ncbi.nlm.nih.gov/32381599
Autor:
Jeff M. Sands, Janet D. Klein
Publikováno v:
Studies of Epithelial Transporters and Ion Channels ISBN: 9783030554538
Urea transporters are a relatively recent discovery in the overall history of kidney physiology. Urea transport proteins were first proposed in the late 1980s when observations of urea permeability could not be explained by paracellular transport or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ea644fa9058a43d7f4cab8f5d274775
https://doi.org/10.1007/978-3-030-55454-5_9
https://doi.org/10.1007/978-3-030-55454-5_9
Publikováno v:
Journal of Medicinal Chemistry. 61:3209-3217
Urea transporter A (UT-A) isoforms encoded by the Slc14a2 gene are expressed in kidney tubule epithelial cells, where they facilitate urinary concentration. UT-A1 inhibition is predicted to produce a unique salt-sparing diuretic action in edema and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669371f36d6572e2f1f762e94e762440
https://doi.org/10.1021/acs.jmedchem.8b00343
https://doi.org/10.1021/acs.jmedchem.8b00343
Publikováno v:
Kidney International. 91:338-351
Urea transporters (UT) are a family of transmembrane urea-selective channel proteins expressed in multiple tissues and play an important role in the urine concentrating mechanism of the mammalian kidney. UT inhibitors have been identified to have diu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5922981ffdf5412f618d457533bc7df
https://doi.org/10.1016/j.kint.2016.09.017
https://doi.org/10.1016/j.kint.2016.09.017
Autor:
Jeff M. Sands, Janet D. Klein
Publikováno v:
Current Opinion in Nephrology and Hypertension. 25:444-451
Urea is transported by urea transporter proteins in kidney, erythrocytes, and other tissues. Mice in which different urea transporters have been knocked out have urine-concentrating defects, which has led to the development and testing of urea transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e79db6739c237c6216f113a20f4d6c9
https://doi.org/10.1097/mnh.0000000000000252
https://doi.org/10.1097/mnh.0000000000000252
Autor:
Gavin Stewart
Publikováno v:
British Journal of Pharmacology. 164:1780-1792
In mammals, urea is the main nitrogenous breakdown product of protein catabolism and is produced in the liver. In certain tissues, the movement of urea across cell membranes is specifically mediated by a group of proteins known as the SLC14A family o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94aac7afbe6032883c5cf739f373fb31
https://doi.org/10.1111/j.1476-5381.2011.01377.x
https://doi.org/10.1111/j.1476-5381.2011.01377.x
Autor:
Craig P. Smith
Publikováno v:
Experimental Physiology. 94:180-185
Urea transporters (UTs) encoded by the Slc14a1 (UT-B) and Slc14a2 (UT-A) genes mediate urea flux across cellular membranes. Considerable research has accrued detailing the function and distribution of members of both subfamilies. Much research effort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d654acefb994fde439b73d48f327202d
https://doi.org/10.1113/expphysiol.2008.043042
https://doi.org/10.1113/expphysiol.2008.043042