Zobrazeno 1 - 10
of 153
pro vyhledávání: '"SL Perry"'
Autor:
David G. Jayne, Gemma Armstrong, SL Perry, Tom I. Maisey, Mohammed Ibrahim Khot, Thomas A. Hughes, Nicholas P. West, Jim Tiernan
Publikováno v:
International Journal of Experimental Pathology
The transmembrane protein, c-Met, is thought to be overexpressed and activated in colorectal cancer (CRC). This study explored its potential as a diagnostic tissue biomarker for CRC in a large human CRC tissue collection obtained from a randomized cl
Autor:
Henry Watson, SL Perry, Philip Quirke, Amanda D. Race, Paul M. Loadman, Giles J. Toogood, Gael Nana, Mark A. Hull, Suparna Mitra, Henry M. Wood, Caroline Young
Publikováno v:
The Journal of Nutrition
Background Oral administration of purified omega-3 (ω-3) PUFAs is associated with changes to the fecal microbiome. However, it is not known whether this effect is associated with increased PUFA concentrations in the gut. Objectives We investigated t
Autor:
Milene Volpato, John Hutchinson, Catriona Marshall, P. Louise Coletta, Jade A. Spencer, Nicola Ingram, SL Perry, Anna Nicolaou, Paul M. Loadman, Mark A. Hull, Amanda D. Race
Publikováno v:
Nicolaou, A & et al. 2020, ' Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid ', Cancer Chemotherapy and Pharmacology . https://doi.org/10.1007/s00280-020-04157-2
Cancer Chemother Pharmacol
Cancer Chemotherapy and Pharmacology
Cancer Chemother Pharmacol
Cancer Chemotherapy and Pharmacology
PurposeThe naturally-occurring omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) is safe, well-tolerated and inexpensive, making it an attractive anti-cancer intervention. However, EPA has only modest anti-colorectal cancer (CRC) activit
Autor:
Mark A. Levenstein, Gemma Armstrong, Helen Andrew, M. Ibrahim Khot, David G. Jayne, SL Perry, Nikil Kapur, T Maisey, Hafdis S. Svavarsdottir, Greg de Boer
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Three-dimensional (3D) spheroidal cell cultures are now recognised as better models of cancers as compared to traditional cell cultures. However, established 3D cell culturing protocols and techniques are time-consuming, manually laborious and often
Autor:
Nikil Kapur, Thomas A. Hughes, David G. Jayne, Gemma Armstrong, SL Perry, Helen Andrew, T Maisey, M. Ibrahim Khot
Publikováno v:
Photodiagnosis and Photodynamic Therapy. 23:221-229
Background: Photodynamic Therapy (PDT) is an attractive modality for treating solid cancers. This study evaluates the efficacy of Hypericin-PDT as a cytotoxic therapy in colorectal cancer (CRC), using 2D cell cultures and 3D multicellular tumour sphe
Autor:
Mark A. Hull, Clare L. Lawton, Louise Dye, Suparna Mitra, Henry Watson, Giles J. Toogood, Fiona Croden, M Taylor, Paul M. Loadman, SL Perry, Henry M. Wood, Phil Quirke, Jade A. Spencer
Publikováno v:
Gut. 67:1974-1983
ObjectiveOmega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatible with an
Autor:
M Gill, S Mills, CE Parker, MG Bramble, Yvonne Bury, E Walsh, Roisin Bevan, SL Perry, Colin J Rees, Mark A. Hull, D. M. Bradburn
Publikováno v:
British Journal of Cancer
Background: We measured biomarkers of tumour growth and vascularity in interval and screen-detected colorectal cancers (CRCs) in the English Bowel Cancer Screening Programme in order to determine whether rapid tumour growth might contribute to interv
Autor:
Gemma Marston, Mark A. Hull, Milene Volpato, SL Perry, Alessandra Munarini, Andrea Belluzzi, Nicola Ingram, Paul M. Loadman, Amanda D. Race, Gillian Hawcroft, Andrew J. Cockbain, PL Coletta
Publikováno v:
British Journal of Pharmacology. 166:1724-1737
BACKGROUND AND PURPOSE The omega-3 polyunsaturated fatty acid (PUFA) eicosapentaenoic acid (EPA) has antineoplastic activity at early stages of colorectal carcinogenesis, relevant to chemoprevention of colorectal cancer (CRC). We tested the hypothesi
Publikováno v:
British Journal of Cancer
Colorectal cancer is the third most common cancer in the world and the fourth leading cause of cancer-related death (Shike et al, 1990). In 2007 colorectal cancer accounted for 17.1 deaths per 100 000 persons in the United Kingdom (UK Bowel Cancer St
Autor:
Rashida Anwar, Alexander F. Markham, Ian M. Carr, Will Merchant, Kieran Horgan, SL Perry, Christine P. Diggle, Edlo T Verghese, Rajgopal Achuthan, Nader Touqan
Publikováno v:
BMC Clinical Pathology
Background: Inactivation of wild type P53 by its main cellular inhibitors (MDM2 and MDMX) is a well recognised feature of tumour formation in liposarcomas. MDM2 over-expression has been detected in approximately 80% of liposarcomas but only limited i