An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins.

Autor: Yuan W; Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK., Xia Y; BGI-Shenzhen, Shenzhen 518083, China., Bell CG; Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK., Yet I; Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Ward KJ; Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK., Gao F; BGI-Shenzhen, Shenzhen 518083, China., Loomis AK; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, USA., Hyde CL; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, USA., Wu H; BGI-Shenzhen, Shenzhen 518083, China., Lu H; BGI-Shenzhen, Shenzhen 518083, China., Liu Y; BGI-Shenzhen, Shenzhen 518083, China., Small KS; Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK., Viñuela A; Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK., Morris AP; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK [2] Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Berdasco M; Cancer Epigenetics and Biology Program (PEBC), Hospital Duran i Reynals, Barcelona 08908, Spain., Esteller M; 1] Cancer Epigenetics and Biology Program (PEBC), Hospital Duran i Reynals, Barcelona 08908, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia 08907, Spain [3] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia 08010, Spain., Brosnan MJ; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA., Deloukas P; 1] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK [2] King Abdulaziz University, Jeddah 22254, Saudi Arabia., McCarthy MI; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, oxford OX3 7LE, UK [3] Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LE, UK., John SL; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA., Bell JT; Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK., Wang J; 1] BGI-Shenzhen, Shenzhen 518083, China [2] King Abdulaziz University, Jeddah 22254, Saudi Arabia [3] Department of Biology, University of Copenhagen, Copenhagen DK-2200, Denmark [4] The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark., Spector TD; Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK.

Publikováno v: Nature communications [Nat Commun] 2014 Dec 12; Vol. 5, pp. 5719. Date of Electronic Publication: 2014 Dec 12.

An atlas of genetic influences on human blood metabolites.

Autor: Shin SY; Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK., Fauman EB; Pfizer Worldwide Research and Development, Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Cambridge MA, 02140, USA., Petersen AK; Institute of Genetic Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany., Krumsiek J; Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany., Santos R; European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, CB10 1SD, UK., Huang J; Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK., Arnold M; Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany., Erte I; Department of Twin research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK., Forgetta V; Department of Human Genetics, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal H3A 1A5, Canada., Yang TP; Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK., Walter K; Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK., Menni C; Department of Twin research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK., Chen L; Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK.; Department of Hematology, University of Cambridge, Long Road, Cambridge CB2 2PT, UK., Vasquez L; Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK., Valdes AM; Department of Twin research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.; School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK., Hyde CL; Pfizer Worldwide Research and Development, Clinical Research Statistics, 558 Eastern Point Rd, Groton CT 06340, USA., Wang V; Pfizer Worldwide Research and Development, Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Cambridge MA, 02140, USA., Ziemek D; Pfizer Worldwide Research and Development, Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Cambridge MA, 02140, USA., Roberts P; Pfizer Worldwide Research and Development, Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Cambridge MA, 02140, USA., Xi L; Pfizer Worldwide Research and Development, Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Cambridge MA, 02140, USA., Grundberg E; Department of Human Genetics, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal H3A 1A5, Canada.; Genome Quebec Innovation Centre, McGill University, Montreal QCH3A 1A5, Canada., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany., Richards JB; Department of Human Genetics, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal H3A 1A5, Canada.; Department of Medicine, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal H3A 1A5, Canada., Mohney RP; Metabolon Inc., 617 Davis Drive, Durham, NC 27713, USA., Milburn MV; Metabolon Inc., 617 Davis Drive, Durham, NC 27713, USA., John SL; Pfizer Worldwide Research and Development, Cardiovascular and Metabolic Diseases, 620 Memorial Drive, Cambridge, MA 02139, USA., Trimmer J; Pfizer Worldwide Research and Development, Cardiovascular and Metabolic Diseases, 620 Memorial Drive, Cambridge, MA 02139, USA., Theis FJ; Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany.; Department of Mathematics, Technische Universität München, Garching, Germany., Overington JP; European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, CB10 1SD, UK., Suhre K; Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany.; Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar., Brosnan MJ; Pfizer Worldwide Research and Development, Clinical Research Statistics, 558 Eastern Point Rd, Groton CT 06340, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany., Kastenmüller G; Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany., Spector TD; Department of Twin research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK., Soranzo N; Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK.; Department of Hematology, Long Road, Cambridge CB2 0PT, UK.

Publikováno v: Nature genetics [Nat Genet] 2014 Jun; Vol. 46 (6), pp. 543-550. Date of Electronic Publication: 2014 May 11.

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.

Autor: Sorge RE; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada., Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS

Publikováno v: Nature medicine [Nat Med] 2012 Mar 25; Vol. 18 (4), pp. 595-9. Date of Electronic Publication: 2012 Mar 25.

Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild cognitive impairment.

Autor: Hu X; PharmaTx Precision Medicine, Pfizer, Pfizer Global R&D, Groton, CT, USA. Xiaolan.Hu@pfizer.com, Pickering EH, Hall SK, Naik S, Liu YC, Soares H, Katz E, Paciga SA, Liu W, Aisen PS, Bales KR, Samad TA, John SL

Publikováno v: Translational psychiatry [Transl Psychiatry] 2011 Nov 15; Vol. 1, pp. e54. Date of Electronic Publication: 2011 Nov 15.

Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS).

Autor: Limer KL; ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom. kate.limer@manchester.ac.uk, Pye SR, Thomson W, Boonen S, Borghs H, Vanderschueren D, Huhtaniemi IT, Adams JE, Ward KA, Platt H, Payne D, John SL, Bartfai G, Casanueva F, Finn JD, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Silman AJ, Wu FC, O'Neill TW

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2009 Feb; Vol. 24 (2), pp. 314-23.