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Publikováno v:
Glycobiology
Skp1 is hydroxylated by an O2-dependent prolyl hydroxylase (PhyA) that contributes to O2-sensing in the social amoeba Dictyostelium and the mammalian pathogen Toxoplasma gondii. HO-Skp1 is subject to glycosylation and the resulting pentasaccharide af
Autor:
Camelia M. Monoranu, Peter Riederer, Silvia Mandel, Moussa B.H. Youdim, Josefine Ruder, Edna Grünblatt
Publikováno v:
Neurotoxicity Research. 33:560-568
Parkinson's disease is the most common neurodegenerative disorder after Alzheimer's disease, with the majority of cases being sporadic or "idiopathic". The aetiology of the sporadic form is still unknown, but there is a broad consensus that Parkinson
Autor:
Marc Tessier-Lavigne, Yuya Yamagishi
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 774-782 (2016)
SummaryAxon degeneration is a tightly regulated, self-destructive program that is a critical feature of many neurodegenerative diseases, but the molecular mechanisms regulating this program remain poorly understood. Here, we identify S-phase kinase-a
Axon degeneration is a prominent event in many neurodegenerative disorders. Axon injury stimulates an intrinsic self-destruction program that culminates in activation of the prodegeneration factor SARM1 and local dismantling of damaged axon segments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d7835e08826ec7def9407b1c85b0d4
https://europepmc.org/articles/PMC6140512/
https://europepmc.org/articles/PMC6140512/
Autor:
Amol S. Phule, Maganti Sheshu Madhav, Kalyani M. Barbadikar, P. Ananda Kumar, M.B.B. Prasad Babu, P. Senguttuvel
Publikováno v:
3 Biotech. 8
A set of reference genes expressing stably under aerobic and anaerobic conditions in rice is essential to execute omics studies relating to aerobic adaptations. Stability of expression of ten rice reference genes, viz. Actin, eEF-1a, eIF-5C, Exp1, Ex
Autor:
Edward C. Lauterbach
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 40:236-239
Recently, the genes p19 S-phase kinase-associated protein 1A (SKP1), huntingtin interacting protein-2 (UBE2K), aldehyde dehydrogenase family 1 subfamily A1 (ALDH1A1), 19 S proteasomal protein PSMC4, and heat shock 70-kDa protein 8 (HSPA8) have been f
Publikováno v:
Neurodegenerative Diseases. 7:108-111
Background: High-throughput gene-based platform studies in human postmortem substantia nigra (SN) from sporadic Parkinson’s disease (PD) cases have revealed significant dysregulation of genes involved in biological processes linked to previously es
Publikováno v:
Parkinsonism & Related Disorders. 15:S148-S151
Large-scale transcriptomics analysis of gene expression profile of sporadic Parkinson's disease (PD) substantia nigra (SN) has identified a number of differentially expressed genes participating in the neurotoxic cascade of DA neurons death, in parti
Autor:
Edna Grünblatt, Gideon Rechavi, Moussa B.H. Youdim, Ninette Amariglio, Silvia Mandel, Peter Riederer, Jasmine Jacob Hirsch
Publikováno v:
Annals of the New York Academy of Sciences. 1053:356-375
Sporadic Parkinson's disease (PD) constitutes 99% of the disorder, while the remaining 1% of the cases is of familial (genetic) origin. The mutations reported to be associated with familial PD indicate impairment in protein processing and misfolding,