Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis.

Autor: Ramessur R; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Saklatvala J; Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King's College London, London, United Kingdom., Budu-Aggrey A; MRC Integrative Epidemiology Unit at University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, Bristol, United Kingdom., Ostaszewski M; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Möbus L; Finnish Hub for Development and Validation of Integrated Approaches, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Greco D; Finnish Hub for Development and Validation of Integrated Approaches, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Uusimaa, Finland., Ndlovu M; Department of Immunology Research, UCB, Brussels, Belgium., Mahil SK; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Barker JN; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Brown S; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.; Department of Dermatology, NHS Lothian, Edinburgh, Scotland, United Kingdom., Paternoster L; MRC Integrative Epidemiology Unit at University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, Bristol, United Kingdom.; NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom., Dand N; Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King's College London, London, United Kingdom., Simpson MA; Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King's College London, London, United Kingdom., Smith CH; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.

Publikováno v: JAMA cardiology [JAMA Cardiol] 2024 Nov 01; Vol. 9 (11), pp. 1009-1017.

Inflammatory memory in psoriasis: From remission to recurrence.

Autor: Francis L; St John's Institute of Dermatology, King's College London and Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom., Capon F; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom., Smith CH; St John's Institute of Dermatology, King's College London and Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom., Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Mahil SK; St John's Institute of Dermatology, King's College London and Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom. Electronic address: satveer.mahil@kcl.ac.uk.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Jul; Vol. 154 (1), pp. 42-50. Date of Electronic Publication: 2024 May 17.

Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade.

Autor: Francis L; St John's Institute of Dermatology, King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK., McCluskey D; Department of Medical and Molecular Genetics, King's College London, London, UK., Ganier C; Center of Gene Therapy and Regenerative Medicine, King's College London, London, UK., Jiang T; St John's Institute of Dermatology, King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK., Du-Harpur X; Center of Gene Therapy and Regenerative Medicine, King's College London, London, UK., Gabriel J; Center of Gene Therapy and Regenerative Medicine, King's College London, London, UK., Dhami P; Genomics Research Platform, King's College London NIHR Biomedical Research Centre, London, UK., Kamra Y; Genomics Research Platform, King's College London NIHR Biomedical Research Centre, London, UK., Visvanathan S; Boehringer Ingelheim Pharmaceuticals, Ridgefield, USA., Barker JN; St John's Institute of Dermatology, King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK., Smith CH; St John's Institute of Dermatology, King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK., Capon F; Department of Medical and Molecular Genetics, King's College London, London, UK. francesca.capon@kcl.ac.uk., Mahil SK; St John's Institute of Dermatology, King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK. satveer.mahil@kcl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Jan 30; Vol. 15 (1), pp. 913. Date of Electronic Publication: 2024 Jan 30.

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.

Autor: Dand N; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; Health Data Research UK, London, UK., Stuart PE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Bowes J; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Manchester, UK., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Nititham J; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA., Saklatvala JR; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Teder-Laving M; Institute of Genomics, University of Tartu, Tartu, Estonia., Thomas LF; Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Traks T; Department of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia., Uebe S; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Assmann G; RUB University Hospital JWK Minden, Department of Rheumatology, Minden, Germany.; Jose-Carreras Centrum for Immuno- and Gene Therapy, University of Saarland Medical School, Homburg, Germany., Baudry D; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Behrens F; Division of Translational Rheumatology, Immunology - Inflammation Medicine, University Hospital, Goethe University, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany.; Division of Rheumatology, University Hospital, Goethe University, Frankfurt am Main, Germany., Billi AC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Brown MA; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; Genomics England, Canary Wharf, London, UK., Burkhardt H; Division of Rheumatology, University Hospital, Goethe University, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany., Capon F; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Chung R; Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London, UK., Curtis CJ; Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London, UK., Duckworth M; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Ellinghaus E; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., FitzGerald O; UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland., Gerdes S; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Griffiths CEM; Centre for Dermatology Research, University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester, UK.; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; Department of Dermatology, King's College Hospital NHS Foundation Trust, London, UK., Gulliver S; Newlab Clinical Research Inc, St. John's, NL, Canada., Helliwell P; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, UK.; Leeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds, UK., Ho P; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Manchester, UK.; The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, UK., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Holmen OL; HUNT Research Centre, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Huang ZM; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Jadon D; Department of Medicine, University of Cambridge, Cambridge, UK., Köhm M; Division of Translational Rheumatology, Immunology - Inflammation Medicine, University Hospital, Goethe University, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany.; Division of Rheumatology, University Hospital, Goethe University, Frankfurt am Main, Germany., Kraus C; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Lamacchia C; Division of Rheumatology, Geneva University Hospital, Geneva, Switzerland., Lee SH; Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London, UK., Ma F; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Mahil SK; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; St John's Institute of Dermatology, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, UK., McHugh N; Royal National Hospital for Rheumatic Diseases and Dept Pharmacy and Pharmacology, University of Bath, UK., McManus R; Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland., Modalsli EH; Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Nissen MJ; Division of Rheumatology, Geneva University Hospital, Geneva, Switzerland., Nöthen M; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Oji V; Department of Dermatology, University of Münster, Münster, Germany., Oksenberg JR; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA., Patrick MT; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Perez-White BE; Department of Dermatology, Northwestern University, Evanston, IL, USA., Ramming A; Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Rech J; Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Rosen C; Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada., Sarkar MK; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Schett G; Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Schmidt B; Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Tejasvi T; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA., Traupe H; Department of Dermatology, University of Münster, Münster, Germany., Voorhees JJ; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Wacker EM; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Warren RB; Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, UK.; Centre for Dermatology Research, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M6 8HD, UK., Wasikowski R; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Weidinger S; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Wen X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Zhang Z; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Barton A; Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, The University of Manchester, Manchester, UK.; The Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, UK., Chandran V; Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Foerster J; College of Medicine, Dentistry, and Nursing, University of Dundee, Dundee, UK., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Gladman DD; Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada., Gudjonsson JE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Gulliver W; Newlab Clinical Research Inc, St. John's, NL, Canada.; Department of Dermatology, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Hüffmeier U; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Kingo K; Department of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.; Dermatology Clinic, Tartu University Hospital, Tartu, Estonia., Kõks S; Perron Institute for Neurological and Translational Science, Nedlands, WA 6009, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia., Liao W; Deparment of Dermatology, University of California San Francisco, San Francisco, CA, USA., Løset M; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.; Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Nair RP; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Rahman P; Memorial University of Newfoundland, St. John's, NL, Canada., Reis A; Institute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany., Smith CH; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; St John's Institute of Dermatology, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, UK., Di Meglio P; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Barker JN; St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.; St John's Institute of Dermatology, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, UK., Tsoi LC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Simpson MA; Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK., Elder JT; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Oct 05. Date of Electronic Publication: 2023 Oct 05.

Systematic review of deep learning image analyses for the diagnosis and monitoring of skin disease.

Autor: Choy SP; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Kim BJ; St George's University Hospitals NHS Foundation Trust, London, UK., Paolino A; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Tan WR; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Lim SML; Maidstone and Tunbridge Wells NHS Trust, Kent, UK., Seo J; Imperial College London, London, UK., Tan SP; Barking, Havering and Redbridge University Hospitals NHS Trust, London, UK., Francis L; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Tsakok T; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Simpson M; Department of Medical and Molecular Genetics, King's College London, London, UK., Barker JNWN; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Lynch MD; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Corbett MS; Center for Reviews and Dissemination, University of York, York, UK., Smith CH; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Mahil SK; St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK. satveer.mahil@kcl.ac.uk.

Publikováno v: NPJ digital medicine [NPJ Digit Med] 2023 Sep 27; Vol. 6 (1), pp. 180. Date of Electronic Publication: 2023 Sep 27.