Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells

Autor: T Haimowitz, Arnone, SK Chunduru, GS Kapoor, Y Mitsuuchi, CG Begley, SC Beck, ME Seipel, Y Deng, SM Condon, CA Benetatos, MA McKinlay

Publikováno v: Cell Death Discovery

The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines results in induction of cell death. A variety of IAP antagonist compounds targeting the baculov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b760e7bc7de64e5935eefe0ef26fbd95
http://europepmc.org/articles/PMC5238498

Biographical Feature: Marc S. Collett (23 May 1951-11 June 2022): the Battle against Viral Disease Has Lost a Valiant Warrior, and the World Has Lost a Splendid Human Being.

Autor: Glassman KF; Consultant, Prescott, Arizona, USA., Brugge JS; Ludwig Center, Harvard Medical Schoolgrid.471403.5, Harvard University, Boston, Massachusetts, USA., Purchio AF; Salt Lake City, Utah, USA., Kakach LT; Cargill, Inc., Wayzata, Minnesota, USA., Fuerst TR; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA., Woods RM; Consultant, Darnestown, Maryland, USA., Stover CK; Stoneham, Massachusetts, USA., Chunduru SK; Idera Pharmaceuticals, Inc., Cambridge, Massachusetts, USA., Hincks JR; ViroDefense, Inc., Chevy Chase, Maryland, USA., McKinlay MA; The Task Force for Global Health, Decatur, Georgia, USA., Nash CH; Nash Consulting, LLC, Chester Spring, Pennsylvania, USA., Pevear DC; VenatoRx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Monath TP; Crozet BioPharma LLC, Lexington, Massachusetts, USA., Rice CM; The Rockefeller Universitygrid.134907.8, New York, New York, USA., Peters P; Hamburg, Minnesota, USA.

Publikováno v: Journal of virology [J Virol] 2023 Jan 31; Vol. 97 (1), pp. e0164322. Date of Electronic Publication: 2022 Dec 05.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

Autor: Tanzer MC; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Khan N; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Rickard JA; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Etemadi N; Olivia Newton John Cancer Research Institute, Heidelberg, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3084, Australia., Lalaoui N; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Spall SK; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Hildebrand JM; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Segal D; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Miasari M; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3084, Australia., Chau D; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Wong WL; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland., McKinlay M; TetraLogic Pharmaceuticals Corporation, Malvern, PA 19355, USA., Chunduru SK; TetraLogic Pharmaceuticals Corporation, Malvern, PA 19355, USA., Benetatos CA; TetraLogic Pharmaceuticals Corporation, Malvern, PA 19355, USA., Condon SM; TetraLogic Pharmaceuticals Corporation, Malvern, PA 19355, USA., Vince JE; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Herold MJ; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia., Silke J; Cell Signalling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2017 Mar; Vol. 24 (3), pp. 481-491. Date of Electronic Publication: 2017 Jan 20.

Negative feedback regulation of NF-κB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosis.

Autor: Gray CM; Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, United States., McCorkell KA; Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, United States., Chunduru SK; PKPD Biosciences, 717 Constitution Drive, Suite 104, Exton, PA 19341, United States., McKinlay MA; Task Force for Global Health, 325 Swanton Way, Decatur, GA 30030, United States., May MJ; Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, United States; Mari Lowe Center for Comparative Oncology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, United States. Electronic address: maym@vet.upenn.edu.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2014 Jul 18; Vol. 450 (1), pp. 341-6. Date of Electronic Publication: 2014 Jun 02.

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

Autor: Benetatos CA; Authors' Affiliations: TetraLogic Pharmaceuticals, 343 Phoenixville Pike, Malvern, Pennsylvania; and Tsinghua University School of Medicine, Beijing, China., Mitsuuchi Y, Burns JM, Neiman EM, Condon SM, Yu G, Seipel ME, Kapoor GS, Laporte MG, Rippin SR, Deng Y, Hendi MS, Tirunahari PK, Lee YH, Haimowitz T, Alexander MD, Graham MA, Weng D, Shi Y, McKinlay MA, Chunduru SK

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2014 Apr; Vol. 13 (4), pp. 867-79. Date of Electronic Publication: 2014 Feb 21.