Zobrazeno 1 - 10 of 73 770 pro vyhledávání: '"SIX genes"'
1
Akademický článek
Detection of polymorphisms in six genes and their association analysis with litter size in sheep.
Autor: Liu, Kai1 (AUTHOR), Liu, Yufang1 (AUTHOR) aigaiy@126.com, Chu, Mingxing1 (AUTHOR) mxchu@263.net
Publikováno v: Animal Biotechnology. Nov2024, Vol. 35 Issue 1, p1-10. 10p.
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2
Akademický článek
Analysis of Codon Usage Bias of Six Genes of Replicase/Coat Protein of Tobacco Mosaic Virus.
Autor: Cheeran, Kevin1, Suresh, Kuralayanapalya Puttahonnappa2, Jacob, Siju Susan2, Gowda, Chirathahalli Shivamurthy Sathish2, Gejendiran, Narayanan2, Sridevi, Rajangam2, Patil, Sharanagouda S.2 sharanspin13@gmail.com
Publikováno v: Indian Journal of Agricultural Research. Aug2024, Vol. 58 Issue 4, p720-726. 7p.
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4
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5
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6
Akademický článek
Online application for the diagnosis of atherosclerosis by six genes.
Autor: Zhao, Zunlan1 (AUTHOR), Chen, Shouhang2 (AUTHOR), Wei, Hongzhao3 (AUTHOR), Ma, Weile1 (AUTHOR), Shi, Weili1 (AUTHOR), Si, Yixin1 (AUTHOR), Wang, Jun1 (AUTHOR), Wang, Liuyi1 (AUTHOR), Li, Xiqing3 (AUTHOR) xiqinglee@zzu.edu.cn
Publikováno v: PLoS ONE. 4/10/2024, Vol. 19 Issue 4, p1-15. 15p.
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7
Akademický článek
Cross-Tissue Regulatory Network Analyses Reveal Novel Susceptibility Genes and Potential Mechanisms for Endometriosis Endometriosis (EMT) is a common gynecological disease with a strong genetic component, while its precise etiology remains elusive. This study aims to integrate transcriptome-wide association study (TWAS), Mendelian randomization (MR), and bioinformatics analyses to reveal novel putatively causal genes and potential mechanisms. We obtained summary-level data of the Genotype-Tissue Expression Project (GTEx), v8 expression quantitative loci (eQTL) data, and the genome-wide association study (GWAS) data of EMT and its subtypes from the R11 release results of the FinnGen consortium for analysis. GWAS data of modifiable risk factors were collected from IEU Open GWAS. Cross-tissue TWAS analyses were performed using the unified test for molecular signature (UTMOST), while functional summary-based imputation (FUSION) was employed for single-tissue TWAS analyses. Furthermore, we also conducted multi-marker analysis of genomic annotation (MAGMA) analyses to validate the significant associations. Subsequent Mendelian randomization (MR) and colocalization analysis elucidated the causal associations between the identified genes across various tissues and EMT. To further delve into mechanisms, two-sample network MR analyses were conducted. At last, bioinformatics analyses were employed to enhance our understanding of the functional implications and expression patterns of these identified genes. For EMT, 22 significant gene signals were identified by UTMOST, 615 by FUSION, and 354 by MAGMA. Ultimately, six genes, including CISD2, EFRB, GREB1, IMMT, SULT1E1, and UBE2D3, were identified as candidate susceptibility genes for EMT. Through similar procedures, we identified GREB1, IL1A, and SULT1E1 for EMT of the ovary, and we identified GREB1 for EMT of the pelvic peritoneum, EMT of rectovaginal septum and vagina, and deep EMT. In MR analyses, the expression of IMMT in 2
Autor: Zou, Mingrui1,2,3,4,5 (AUTHOR) 2110301145@stu.pku.edu.cn, Lin, Mingmei1,2,3,4 (AUTHOR) linmingmei2023@163.com, Hu, Kai-Lun1,2,3,4 (AUTHOR) hukailun@bjmu.edu.cn, Li, Rong1,2,3,4 (AUTHOR) hukailun@bjmu.edu.cn
Publikováno v: Biology (2079-7737). Nov2024, Vol. 13 Issue 11, p871. 18p.
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8
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9
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10
Akademický článek
Online application for the diagnosis of atherosclerosis by six genes.
Autor: Zunlan Zhao, Shouhang Chen, Hongzhao Wei, Weile Ma, Weili Shi, Yixin Si, Jun Wang, Liuyi Wang, Xiqing Li
Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0301912 (2024)
BackgroundAtherosclerosis (AS) is a primary contributor to cardiovascular disease, leading to significant global mortality rates. Developing effective diagnostic indicators and models for AS holds the potential to substantially reduce the fatalities
Externí odkaz: https://doaj.org/article/d3284561596349288ff2f0aa9d6df3e5
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