Zobrazeno 1 - 10
of 61
pro vyhledávání: '"SIMON KEANE"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Neuroblastoma is a childhood tumour that is responsible for approximately 15% of all childhood cancer deaths. Neuroblastoma tumours with amplification of the oncogene MYCN are aggressive, however, another aggressive subgroup without MYCN amp
Externí odkaz:
https://doaj.org/article/ef9079707b72466ba92e289298101e02
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased expression of DLG2, a
Externí odkaz:
https://doaj.org/article/ea7db444735f492ebc7edfa8092a4fba
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Neuroblastoma (NB) is a childhood neural crest tumor. There are two groups of aggressive NBs, one with MYCN amplification, and another with 11q chromosomal deletion; these chromosomal aberrations are generally mutually exclusive.
Externí odkaz:
https://doaj.org/article/e21452b582894cbda451a7a0f1f4dda3
Autor:
Fábio Trindade, Francisca Saraiva, Simon Keane, Adelino Leite-Moreira, Rui Vitorino, Homa Tajsharghi, Inês Falcão-Pires
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237000 (2020)
Currently, aortic valve replacement is the only treatment capable of relieving left ventricle pressure overload in patients with severe aortic stenosis. It aims to improve cardiac function and revert hypertrophy, by triggering myocardial reverse remo
Externí odkaz:
https://doaj.org/article/12b7a815d82c45fcac65684f916337b4
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 148:2295-2311
Purpose Loss of expression of DLG2 has been identified in a number of cancers to contribute to the disease by resulting in increased tumor cell proliferation and poor survival. In light of the previous evidence that DLG2 alters the cell cycle and aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650572cea05d08d1beaf0b57b5994792
https://doi.org/10.1007/s00432-022-04029-7
https://doi.org/10.1007/s00432-022-04029-7
Autor:
Lily, Deland, Simon, Keane, Thomas Olsson, Bontell, Henrik, Fagman, Helene, Sjögren, Anders E, Lind, Helena, Carén, Magnus, Tisell, Jonas A, Nilsson, Katarina, Ejeskär, Magnus, Sabel, Frida, Abel
Publikováno v:
Cancer Genomics Proteomics
Background/Aim: Although fusion genes involving the proto-oncogene receptor tyrosine kinase ROS1 are rare in pediatric glioma, targeted therapies with small inhibitors are increasingly being approved for histology-agnostic fusion-positive solid tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fdd0c8f7af2355a7f0a552103fdc21ca
https://pubmed.ncbi.nlm.nih.gov/36316040
https://pubmed.ncbi.nlm.nih.gov/36316040
PurposeLoss of expression of DLG2 has been identified in a number of cancers to contribute to the disease by resulting in increased tumor cell proliferation and poor survival. In light of the previous evidence that DLG2 alters the cell cycle and affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d66f23c3a3c2b0d1be3a1a1d00ef64
https://doi.org/10.21203/rs.3.rs-1299316/v1
https://doi.org/10.21203/rs.3.rs-1299316/v1
Autor:
LILY DELAND, SIMON KEANE, THOMAS OLSSON BONTELL, HENRIK FAGMAN, HELENE SJÖGREN, ANDERS E. LIND, HELENA CARÉN, MAGNUS TISELL, JONAS A. NILSSON, KATARINA EJESKÄR, MAGNUS SABEL, FRIDA ABEL
BACKGROUND/AIM: Although fusion genes involving the proto-oncogene receptor tyrosine kinase ROS1 are rare in pediatric glioma, targeted therapies with small inhibitors are increasingly being approved for histology-agnostic fusion-positive solid tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76905c783246a995ac43a1144e0940b
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-22033
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-22033
Publikováno v:
Scientific reports. 12(1)
Neuroblastoma is a childhood tumour that is responsible for approximately 15% of all childhood cancer deaths. Neuroblastoma tumours with amplification of the oncogene MYCN are aggressive, however, another aggressive subgroup without MYCN amplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312490aecbe1104a586526b462cff4bb
https://pubmed.ncbi.nlm.nih.gov/36396668
https://pubmed.ncbi.nlm.nih.gov/36396668
Publikováno v:
DNA repair. 112
Background In primary neuroblastoma, deletions on chromosome 11q are known to result in an increase in the total number of chromosomal breaks. The DNA double-strand break repair pathways mediated by NHEJ are often upregulated in cancer. DLG2, a candi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa54ac92f0077ed8a327084948b7368c
https://pubmed.ncbi.nlm.nih.gov/35217496
https://pubmed.ncbi.nlm.nih.gov/35217496