Zobrazeno 1 - 10
of 148
pro vyhledávání: '"SILVIA PARAPINI"'
Autor:
Estefanía Calvo-Alvarez, Sarah D’Alessandro, Nunzia Zanotta, Nicoletta Basilico, Silvia Parapini, Lucia Signorini, Federica Perego, Kevin Kamau Maina, Pasquale Ferrante, Annalisa Modenese, Pierluigi Pizzocri, Andrea Ronsivalle, Serena Delbue, Manola Comar
Publikováno v:
BMC Immunology, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background The systemic inflammatory syndrome called “cytokine storm” has been described in COVID-19 pathogenesis, contributing to disease severity. The analysis of cytokine and chemokine levels in the blood of 21 SARS-CoV-2 positive pat
Externí odkaz:
https://doaj.org/article/6eb1b363eac44ad98e0adce025d33ffa
Autor:
Alessandra Altomare, Giovanna Baron, Giulia Cambiaghi, Giulio Ferrario, Beatrice Zoanni, Larissa Della Vedova, Giulio Maria Fumagalli, Sarah D’Alessandro, Silvia Parapini, Serena Vittorio, Giulio Vistoli, Patrizia Riso, Marina Carini, Serena Delbue, Giancarlo Aldini
Publikováno v:
Molecules, Vol 29, Iss 11, p 2702 (2024)
Background: The viral main protease (Mpro) of SARS-CoV-2 has been recently proposed as a key target to inhibit virus replication in the host. Therefore, molecules that can bind the catalytic site of Mpro could be considered as potential drug candidat
Externí odkaz:
https://doaj.org/article/05b4538bfe704fb6a0e0ceb9106c400d
Autor:
Katarzyna Sidoryk, Silvia Parapini, Nicoletta Basilico, Magdalena Zaremba-Czogalla, Marek Kubiszewski, Marcin Cybulski, Jerzy Gubernator, Agnieszka Zagórska, Anna Jaromin
Publikováno v:
Journal of Parasitology Research, Vol 2023 (2023)
New protocol for the preparation of the novel caffeic acid derivatives using the Wittig reaction has been applied to follow the principles of green chemistry. The compounds have been evaluated against chloroquine-sensitive and chloroquine-resistant P
Externí odkaz:
https://doaj.org/article/02de833a697a4bdd82cdc523d373951c
Autor:
Anna Jaromin, Silvia Parapini, Nicoletta Basilico, Magdalena Zaremba-Czogalla, Agnieszka Lewińska, Agnieszka Zagórska, Maria Walczak, Bożena Tyliszczak, Aleksandra Grzeszczak, Marcin Łukaszewicz, Łukasz Kaczmarek, Jerzy Gubernator
Publikováno v:
Bioactive Materials, Vol 6, Iss 4, Pp 1163-1174 (2021)
Alternative therapies are necessary for the treatment of malaria due to emerging drug resistance. However, many promising antimalarial compounds have poor water solubility and suffer from the lack of suitable delivery systems, which seriously limits
Externí odkaz:
https://doaj.org/article/fd740140ed2f4b7bba98aa643597dfb4
Autor:
Nicoletta Basilico, Silvia Parapini, Sarah D’Alessandro, Paola Misiano, Sergio Romeo, Giulio Dondio, Vanessa Yardley, Livia Vivas, Shereen Nasser, Laurent Rénia, Bruce M. Russell, Rossarin Suwanarusk, François Nosten, Anna Sparatore, Donatella Taramelli
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 836 (2023)
The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives. We previously described the excellent in vitro activity
Externí odkaz:
https://doaj.org/article/fe1997e4bed24f56a94dd9fe831661dd
Autor:
Andrea Galbiati, Aureliano Zana, Chiara Borsari, Marco Persico, Stefania Bova, Oleh Tkachuk, Alexandra Ioana Corfu, Lucia Tamborini, Nicoletta Basilico, Caterina Fattorusso, Stefano Bruno, Silvia Parapini, Paola Conti
Publikováno v:
Molecules, Vol 28, Iss 7, p 3172 (2023)
Chiral natural compounds are often biosynthesized in an enantiomerically pure fashion, and stereochemistry plays a pivotal role in biological activity. Herein, we investigated the significance of chirality for nature-inspired 3-Br-acivicin (3-BA) and
Externí odkaz:
https://doaj.org/article/640877a73467454187830b2b5472f319
Autor:
Serena Delbue, Elena Pariani, Silvia Parapini, Cristina Galli, Nicoletta Basilico, Sarah D’Alessandro, Sara Pellegrino, Elena Pini, Samuele Ciceri, Patrizia Ferraboschi, Paride Grisenti
Publikováno v:
Molecules, Vol 28, Iss 6, p 2848 (2023)
Lysozyme (E.C. 3.2.1.17), an about 14 kDa protein and pI 11, widely spread in nature, is present in humans mainly in milk, saliva, and intestinal mucus as a part of innate defense mechanisms. It is endowed with antimicrobial activity due to its actio
Externí odkaz:
https://doaj.org/article/4f92bd36551a4faf955ec76a98c077f9
Autor:
Yolanda Corbett, Silvia Parapini, Federica Perego, Valeria Messina, Serena Delbue, Paola Misiano, Mario Falchi, Francesco Silvestrini, Donatella Taramelli, Nicoletta Basilico, Sarah D’Alessandro
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background The innate immune response against various life cycle stages of the malaria parasite plays an important role in protection against the disease and regulation of its severity. Phagocytosis of asexual erythrocytic stages is well doc
Externí odkaz:
https://doaj.org/article/fe02e78e240a4d3da01e9f7ca157949c
Autor:
Silvio Paone, Sarah D’Alessandro, Silvia Parapini, Francesco Celani, Valentina Tirelli, Manoochehr Pourshaban, Anna Olivieri
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Malaria is still a devastating disease with 228 million cases globally and 405,000 lethal outcomes in 2018, mainly in children under five years of age. The threat of emerging malaria strains resistant to currently available drugs has made th
Externí odkaz:
https://doaj.org/article/054f741b11594b4ba3f56720cd9c53cb
Publikováno v:
Molecules, Vol 28, Iss 4, p 1712 (2023)
Pyrazole core represents a privilege scaffold in medicinal chemistry; a number of pyrazole compounds are endowed with various pharmacological activities in different therapeutic areas including antimalarial treatment. Supported by this evidence, a se
Externí odkaz:
https://doaj.org/article/d36aaccdf19142b78361ceb78895deb3