Zobrazeno 1 - 10
of 215
pro vyhledávání: '"SIK2"'
LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
Autor:
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-18 (2023)
Abstract Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the LKB1‐SIK2 module in restraining uveal melanoma tumor
Externí odkaz:
https://doaj.org/article/1a3e75bad0684eebb8afbad93d505cd9
Publikováno v:
Cells, Vol 13, Iss 18, p 1565 (2024)
The neuronal etiology of obesity is centered around a diet-induced inflammatory state in the arcuate nucleus of the hypothalamus, which impairs the functionality of pro-opiomelanocortine neurons (POMCs) responsible for whole-body energy homeostasis a
Externí odkaz:
https://doaj.org/article/5902c644c26c4fa98d19d4b416405be6
Autor:
Jiaojiao Zhu, Chao Li, Ping Wang, Yuhao Liu, Zhongqiu Li, Zhongmin Chen, Ying Zhang, Bin Wang, Xueping Li, Ziyan Yan, Xinxin Liang, Shenghui Zhou, Xingkun Ao, Maoxiang Zhu, Pingkun Zhou, Yongqing Gu
Publikováno v:
MedComm, Vol 4, Iss 5, Pp n/a-n/a (2023)
Abstract Salt‐inducible kinase 2 (SIK2) belongs to the serine/threonine protein kinases of the AMPK/SNF1 family, which has important roles in cell cycle, tumor, melanogenesis, neuronal damage repair and apoptosis. Recent studies showed that SIK2 re
Externí odkaz:
https://doaj.org/article/f13792f2aa224b5e8542e02aadd73cb5
Akademický článek
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Akademický článek
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Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 38, Iss 9, Pp 869-878 (2022)
Abstract Excessive hepatic lipid accumulation is involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). A previous study showed that the circular RNA (circRNA) PTK2 was significantly downregulated in NAFLD mice. However, the detail
Externí odkaz:
https://doaj.org/article/48caabc99bca43f8ae780948352173f9
Autor:
Xiu Shi, Xuejiao Yu, Juan Wang, Shimin Bian, Qiutong Li, Fengqing Fu, Xinwei Zou, Lin Zhang, Robert C. Bast Jr., Zhen Lu, Lingchuan Guo, Youguo Chen, Jinhua Zhou
Publikováno v:
Molecular Oncology, Vol 16, Iss 13, Pp 2558-2574 (2022)
Salt‐inducible kinase 2 (SIK2; also known as serine/threonine‐protein kinase SIK2) is overexpressed in several cancers and has been implicated in cancer progression. However, the mechanisms by which SIK2 regulates cancer cell motility, migration
Externí odkaz:
https://doaj.org/article/79adc25e6b85439bb2e5bb149f97ac33
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Pulmonary fibrosis is a fatal lung disease with complex pathogenesis and limited effective therapies. Salt-inducible kinase 2 (SIK2) is a kinase that phosphorylates CRTCs and regulates many physiological processes. However, the ro
Externí odkaz:
https://doaj.org/article/da749230360b45dbbed3da97f6f1a544
Publikováno v:
Clinical and Experimental Hypertension, Vol 43, Iss 5, Pp 428-435 (2021)
Salt-inducible kinases (SIKs) represent a subfamily of AMPK family kinases. SIK1 has been shown to act as a mediator during the cellular adaptation to variations in intracellular sodium in a variety of cell types. SIK2, as an isoform of the SIK famil
Externí odkaz:
https://doaj.org/article/c5dd2429334345bca42fe373c73e695c
Autor:
Ka‐Kui Chan, Zahi Abdul‐Sater, Aditya Sheth, Dana K. Mitchell, Richa Sharma, Donna M. Edwards, Ying He, Grzegorz Nalepa, Steven D. Rhodes, D. Wade Clapp, Elizabeth A. Sierra Potchanant
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 860-884 (2022)
The Fanconi anemia (FA) pathway safeguards genomic stability through cell cycle regulation and DNA damage repair. The canonical tumor suppressive role of FA proteins in the repair of DNA damage during interphase is well established, but their functio
Externí odkaz:
https://doaj.org/article/af81c065551f42e1919675d6c2a442a5