Výsledky vyhledávání - "SHUNSAKU NOGUCHI"

Enantiomer-Differentiating Ability of Cyclo(Phe-Pro)4 for Noradrenaline Hydrochloride and Preparation of Complexes with Various Amine Hydrochlorides

Autor: Shunsaku Noguchi, Takashi Ishizu

Publikováno v: Chemical and Pharmaceutical Bulletin. 46:1303-1307

Cyclo(Phe-Pro) 4 (1) formed a 1:1 complex with noradrenaline hydrochloride (NAd.HCl) through intermolecular hydrogen bonds and a hydrophobic effect. The formation constant of the 1:1 complex of 1 with l-NAd.HCl was approximately 12.3 times that of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::242626952d9decee71bfb79ab838a569
https://doi.org/10.1248/cpb.46.1303

Zobrazit plný text záznamu

Reaction of Steroid-17.ALPHA.-hydroxy-17-carboxylic Acids with Carbodiimides. Synthesis of Steroid-17-spiro-5'-(2'-imino-4'-oxazolidinones) and 17-Spiro-5'-(2',4'-oxazolidinediones)

Autor: Shunsaku Noguchi, Ayumi Fujii, Koki Hashitani, Takashi Ishizu

Publikováno v: Chemical and Pharmaceutical Bulletin. 42:1567-1570

Steroid-17α-hydroxy-17-carboxylic acids (2) were allowed to react with carbodiimides (DCCI, DPCI, DTCI, EDCI) to afford 17-spiro-5'-[2'-imino-4'-oxazolidinones] (3-5, 11), 17-spiro-5'-[2', 4'-oxazolidinediones] (7-9)and N-acylureas (10), depending o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::511c4646ba0ca5de14ee07b028b56eea
https://doi.org/10.1248/cpb.42.1567

Zobrazit plný text záznamu

ChemInform Abstract: Reaction of Steroid-17α-hydroxy-17-carboxylic Acids with Carbodiimides. Synthesis of Steroid-17-spiro-5′-(2′-imino-4′- oxazolidinones) and 17-Spiro-5′-(2′,4′-oxazolidinediones)

Autor: Shunsaku Noguchi, Koki Hashitani, Takashi Ishizu, Ayumi Fujii

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a911049e31470ceb7a8ca1f57db5d34a
https://doi.org/10.1002/chin.199513245

Zobrazit plný text záznamu

ChemInform Abstract: Solution Conformation of Ginseng Tetrapeptide H-L-Val-γ-D-Glu-D-Arg-Gly-OH

Autor: Shunsaku Noguchi, Masako Fujiwara, Takashi Ishizu, Akira Yagi

Publikováno v: ChemInform. 29

The ginseng tetrapeptide H-L-Val-γ-D-Gly-D-Arg-Gly-OH (1) was synthesized using a solution-phase methodology, and its solution conformation in dimethyl sulfoxide (DMSO)-d 6 was determined by a combination of NMR and computational techniques with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::027f97446e1a4c547dd4ddd247eaf0f9
https://doi.org/10.1002/chin.199841206

Zobrazit plný text záznamu

Enantiomer-Differentiating Ability of Cyclo(L-Phe-L-Pro)4 Having a Rigid Skeleton for Phenylalanine Methylester Hydrochloride

Autor: Shunsaku Noguchi, Takashi Ishizu

Publikováno v: Chemical and Pharmaceutical Bulletin. 45:1202-1204

The formation constant of the 1 : 1 complex of cyclo(L-Phe-L-Pro)4 (1) with L-PheOMe·HCl was about 13.2 times that of the complex with D-PheOMe·HCl. The 1 : 1 complex of 1 with L-PheOMe·HCl formed three intermolecular hydrogen bonds between Pro2 C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4f58aaaf7e2db83867c7faf7a13dac6
https://doi.org/10.1248/cpb.45.1202

Zobrazit plný text záznamu

Complex Formation of Cyclo(L-Phe-L-Pro)4 with Noradrenaline Hydrochloride

Autor: Jungo Hirayama, Shunsaku Noguchi, Takashi Ishizu

Publikováno v: Chemical and Pharmaceutical Bulletin. 42:1146-1148

The 13C-NMR spectrum of cyclo(L-Phe-L-Pro)4 (1) and DL-noradrenaline hydrochloride (DL-NA·HCl) in a mixture of CDCl3 and CD3OD suggested the formation of a complex, which was demonstrated to be 1 : 1 from examination of the titration curves. The com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00267b4ed721f80cc78960c4501f76ba
https://doi.org/10.1248/cpb.42.1146

Zobrazit plný text záznamu

Preparation and Complex Formation of Cyclic Octapeptides Containing L-Proline Residues with Phenylalanine Methylester Hydrochloride

Autor: Jungo Hirayama, Takashi Ishizu, Shunsaku Noguchi, Hiroyuki Iwamoto, Junzo Hirose, Keitaro Hiromi

Publikováno v: Chemical and Pharmaceutical Bulletin. 41:2029-2031

Cyclic octapeptides, cyclo[L-Tyr(Bzl)-L-Pro]4 (2) and cyclo(L-Tyr-L-Pro)4 (3), were prepared and their conformations investigated. A C2-symmetric conformation containing two cis peptide bonds was found in 2 in CDCl3 and 3 in CD3OD. Cyclo(L-Phe-L-Pro)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5e2e01f0a49aeb23355cdab538d6d0d
https://doi.org/10.1248/cpb.41.2029

Zobrazit plný text záznamu

Conformational studies of cyclo(L-Phe-L-Pro-Gly-L-Pro)2 by 13C nuclear magnetic resonance

Autor: Takashi Ishizu, Ayumi Fujii, Shunsaku Noguchi

Publikováno v: Chemical and Pharmaceutical Bulletin. 39:1617-1619

The 13C-NMR spectrum (Fig. 2,1) of cyclooctapeptide cyclo(L-phe-L-Pro-Gly-L-Pro)2 (A) in CDC13 suggested that its conformation involved the coexistence of two kinds of C2-symmetric conformation with trans-trans-trans-trans and cis-trans-trans-trans f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126fb228cec27d9d452c5f8c749a6349
https://doi.org/10.1248/cpb.39.1617

Zobrazit plný text záznamu

Growth of cultured human bronchiogenic epithelioid CCD-14 Br cells and dermal fibroblasts, NB1 RGB treated with ginseng tetrapeptide and its isomer

Autor: Akira Yagi, Nobuyuki Okamura, Hiroshi Itoh, Shunsaku Noguchi, Takashi Ishizu

Publikováno v: Planta medica. 62(2)

The configurations of the component amino acids in ginseng tetrapeptide 1 isolated from Panax ginseng were determined by HPLC with an optical resolution column and the structure of 1 was established to be H-L-Val-gamma-D-Glu-D-Arg- Gly-OH. Synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d797e5da5f3127545bddfa5db964a28b
https://pubmed.ncbi.nlm.nih.gov/8657740

Zobrazit plný text záznamu

Conformational studies of cyclo(L-Phe-L-Pro-Gly-L-Pro)2 by 1H- and 13C-nuclear magnetic resonance spectroscopy, and its enantioface-differentiating ability

Autor: Ayumi Fujii, Shunsaku Noguchi, Takashi Ishizu

Publikováno v: Chemicalpharmaceutical bulletin. 41(2)

Analyses of the 1H- and 13C-nuclear magnetic resonance (1H- and 13C-NMR) spectra of the cyclooctapeptide cyclo (L-Phe-L-Pro-Gly-L-Pro)2 (3) in CDCl3 with the aid of the C-H correlated spectroscopy (C-H COSY) two-dimensional NMR spectrum (Fig. 2) sugg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1300fced6eb7b6104603a9b698444ecf
https://pubmed.ncbi.nlm.nih.gov/8500196

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání