Zobrazeno 1 - 10
of 45
pro vyhledávání: '"SHUICHI TAWARA"'
Autor:
Shuichi Tawara, Seitaro Mutoh, Fumiaki Ikeda, Etsuko Watabe, Yumi Iguchi, Satoru Matsumoto, Katsuyuki Maki, Ann R. Holmes
Publikováno v:
Scopus-Elsevier
The aim of this study was to compare the pharmacodynamics of the azole antifungal drugs fluconazole, itraconazole and ketoconazole, and the polyene antifungal amphotericin B, in a mouse model of disseminated Candida albicans infection. In order to di
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:1376-1381
The characteristics of in vitro micafungin (FK463) antifungal activity against six species of dimorphic fungi were investigated in accordance with the NCCLS M27-A microdilution methods. MICs of micafungin, amphotericin B, itraconazole, and fluconazol
Autor:
Satoru Matsumoto, Kohji Kawabata, Yoshiteru Eikyu, Shuichi Tawara, Yoshimi Matsumoto, Hirofumi Yamamoto, Hisashi Takasugi, Shinya Okuda, Hirokazu Tanaka
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:1535-1545
A series of 3-(4-pyrazolylmethylthio)cephalosporins with various C-7 side chains was designed, synthesized and evaluated for antibacterial activity and oral absorption in rats. Antibacterial activity against Haemophilus influenzae was markedly increa
Autor:
Akiko Ikemoto, Keizo Matsumoto, Yoshimi Wakai, Yoshimi Matsumoto, Shuichi Tawara, Fumiaki Ikeda
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:2450-2454
Typhoid fever continues to be one of the major public health problems in developing countries. Moreover, a transferable plasmid encoding resistance to chloramphenicol, co-trimoxazole, and ampicillin has spread to Salmonella enterica serovar Typhi in
Autor:
Takeshi Terasawa, Hisashi Takasugi, Hirokazu Tanaka, Satoru Matsumoto, Ayako Nakamura, Hirofumi Yamamoto, Yoshimi Matsumoto, Kohji Kawabata, Shuichi Tawara
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:465-475
A series of 7β-[( Z )-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-(heteroarylmethylthio)cephalosporins was designed, synthesized and evaluated for antibacterial activity and oral absorption in rats. Antibacterial activity was markedly influen
Autor:
Keiji Matsuda, Yoshiki Yoshida, Satoru Matsumoto, Shuichi Tawara, Hisashi Takasugi, Yoshimi Matsumoto, Hiroshi Sasaki
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:2317-2335
The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of cephem derivatives are described. Introduction of thio-heterocyclic groups containing N- and S-atoms to the 3-position and phenyl or thienyl acetamido groups
Autor:
Takeshi Terasawa, Kohji Kawabata, Hirofumi Yamamoto, Satoru Matsumoto, Shuichi Tawara, Kazuo Sakane, Ayako Nakamura, Yoshimi Matsumoto
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:1159-1170
A series of 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamid o]cephalosporins having a pyridine ring connected through various spacer moieties at the C-3 position was designed and synthesized and evaluated for antibacterial activity and oral
Autor:
Shogo Kuwahara, Toshio Goto, Satoru Matsumoto, Yuji Watanabe, Katsuyuki Maki, Etsuko Watabe, Fumio Matsumoto, Shuichi Tawara, Fumiaki Ikeda, Yoshimi Wakai
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:614-618
The efficacy of intravenous injection of FK463, a novel water-soluble lipopeptide, was evaluated in mouse models of disseminated candidiasis and aspergillosis and was compared with those of fluconazole (FLCZ) and amphotericin B (AMPH-B). In the candi
Publikováno v:
The Journal of Antibiotics. 53:1223-1227
Autor:
Kazumi Otomo, Noriko Teratani, Katsuyuki Maki, Akira Yamada, Hidenori Ohki, Hisashi Takasugi, Yoshihiko Morishita, Masaki Tomishima, Hirokazu Tanaka, Fumiaki Ikeda, Koji Kawabata, Fumio Matsumoto, Shogo Kuwahara, Toshio Goto, Shuichi Tawara, Kazuo Sakane
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:57-62
The currently available antifungal drugs for the treatment of deep-seated mycoses are limited to amphotericin B (AMPH-B), azole compounds, and flucytosine. AMPH-B remains the drug of choice for the treatment of most fungal diseases because it has bro