Výsledky vyhledávání - "SHP2 phosphatase"

Akademický článek

Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet

Autor: Michelangelo Marasco, John Kirkpatrick, Teresa Carlomagno, Jochen S. Hub, Massimiliano Anselmi

Publikováno v: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1169-1180 (2024)

SHP2 is a tyrosine phosphatase that plays a regulatory role in multiple intracellular signaling cascades and is known to be oncogenic in certain contexts. In the absence of effectors, SHP2 adopts an autoinhibited conformation with its N-SH2 domain bl

Externí odkaz: https://doaj.org/article/0029acf72ec94573abd1f3e2e607cb5f

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Akademický článek

PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

Autor: Federica Liotti, Narender Kumar, Nella Prevete, Maria Marotta, Daniela Sorriento, Caterina Ieranò, Andrea Ronchi, Federica Zito Marino, Sonia Moretti, Renato Colella, Efiso Puxeddu, Simona Paladino, Yoshihito Kano, Michael Ohh, Stefania Scala, Rosa Marina Melillo

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)

Abstract Background The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 and PD-L2 are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express the PD-Ls that bind PD-1 on immune cells, inhibiting their acti

Externí odkaz: https://doaj.org/article/2f4f62c217e14f8f9af474f8e752ef34

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Akademický článek

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Akademický článek

Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review

Autor: Mojdeh Abbasi, Vivek Gupta, Nitin Chitranshi, Yuyi You, Yogita Dheer, Mehdi Mirzaei, Stuart L. Graham

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

SH2 domain-containing tyrosine phosphatase-2 (PTPN11 or Shp2) is a ubiquitously expressed protein that plays a key regulatory role in cell proliferation, differentiation and growth factor (GF) signaling. This enzyme is well expressed in various retin

Externí odkaz: https://doaj.org/article/c44b7c0164c14e4a9bb54bfef44aee51

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Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner

Autor: Rashi Rajput, Mehdi Mirzaei, Nitin Chitranshi, Ghasem Hosseini Salekdeh, Veer Bala Gupta, Robert G. Parton, Stuart L. Graham, Kanishka Pushpitha, K. B. Devaraj, Mojdeh Abbasi, Reza Ranjbaran, Vivek Gupta, Yuyi You

Publikováno v: Theranostics

SH2 domain containing tyrosine phosphatase 2 (Shp2; PTPN11) regulates several intracellular pathways downstream of multiple growth factor receptors. Our studies implicate that Shp2 interacts with Caveolin-1 (Cav-1) protein in retinal ganglion cells (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043a6f38aa76a9ede23f78b7158232b5
http://europepmc.org/articles/PMC8120201

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Akademický článek

TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders

Autor: Stuart L. Graham, Alexander Klistorner, Vivek K. Gupta, Yuyi You, Veer Bala Gupta

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 10122-10142 (2013)

The Trk family of receptors play a wide variety of roles in physiological and disease processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in particular has attracted major attention due to its critical role in signall

Externí odkaz: https://doaj.org/article/e94e0d88dd604292a2fcdd5bee4b4559

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Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions

Publikováno v: Journal of Medicinal Chemistry
Journal of medicinal chemistry, 64(21), 15973-15990. American Chemical Society
Journal of medicinal chemistry (2021). doi:10.1021/acs.jmedchem.1c01371
info:cnr-pdr/source/autori:Bobone, Sara; Pannone, Luca; Biondi, Barbara; Solman, Maja; Flex, Elisabetta; Canale, Viviana Claudia; Calligari, Paolo; De Faveri, Chiara; Gandini, Tommaso; Quercioli, Andrea; Torini, Giuseppe; Venditti, Martina; Lauri, Antonella; Fasano, Giulia; Hoeksma, Jelmer; Santucci, Valerio; Cattani, Giada; Bocedi, Alessio; Carpentieri, Giovanna; Tirelli, Valentina; Sanchez, Massimo; Peggion, Cristina; Formaggio, Fernando; Den Hertog, Jeroen; Martinelli, Simone; Bocchinfuso, Gianfranco; Tartaglia, Marco; Stella, Lorenzo/titolo:Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions/doi:10.1021%2Facs.jmedchem.1c01371/rivista:Journal of medicinal chemistry/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

We developed a new class of inhibitors of protein-protein interactions of the SHP2 phosphatase, which is pivotal in multiple signaling pathways and a central target in the therapy of cancer and rare diseases. Currently available SHP2 inhibitors targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8496126c4af6cc863ef8628f307fff54
https://pubmed.ncbi.nlm.nih.gov/34714648

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