Zobrazeno 1 - 10
of 43
pro vyhledávání: '"SHOJI KISHIMOTO"'
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:588-593
The spiro-epoxy group of fumagillol (2) was selectively modified and several analogues of AGM-1470 (3) with a (dialkyl)-β-hydroxyethylsulfonium moiety were prepared. These analogues were found to inhibit angiogenesis induced by basic fibroblast grow
Autor:
Shoji, Kishimoto
Publikováno v:
Kyobu geka. The Japanese journal of thoracic surgery. 65(2)
Autor:
Norikazu Tamura, Yoshihiro Matsushita, Toshi Iwama, Katsumi Itoh, Shoji Kishimoto, Setsuo Harada
Publikováno v:
ChemInform. 23
(S)-2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A (1)) is a novel amino acid antibiotic which shows a high affinity for glutamate receptors of the central nervous system. To improve the affinity for glutamate receptors, the stru
Publikováno v:
ChemInform. 26
Tripeptide analogues 2 and 3 containing a dioxoethylene moiety were designed based on the characteristic structure of the naturally occurring human immunodeficiency virus (HIV)-1 protease inhibitors RPI-856 A, B, C and D (1). The compounds (2, 3) pre
Publikováno v:
ChemInform. 26
Autor:
Shoji Kishimoto, Shogo Marui
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:575-579
6-Amino-6-deoxyfumagillol (5) was synthesized by reductive amination of 6-oxo-6-deoxyfumagillol (4), which was obtained by oxidation of fumagillol (2). The reduction proceeded stereoselectively by the equatorial attack of hydride and 5 was found to h
Autor:
Judah Folkman, Shoji Kishimoto, Takeshi Fujita, Harold Brem, Katsuichi Sudo, Tsuneo Kanamaru, Donald E. Ingber
Publikováno v:
Nature. 348:555-557
Neovascularization is critical for the growth of tumours and is a dominant feature in a variety of angiogenic diseases such as diabetic retinopathy, haemangiomas, arthritis and psoriasis. Recognition of the potential therapeutic benefit of controllin
Publikováno v:
31st Joint Propulsion Conference and Exhibit.
Publikováno v:
Chemicalpharmaceutical bulletin. 40(1)
The hydroxy group of fumagillol (3), a degradation product of fumagillin (1), was acylated, sulfonylated, alkylated or carbamoylated, and the anti-angiogenic activity of the resulting products was examined. These compounds inhibited the angiogenesis
Autor:
Toshi Iwama, Shoji Kishimoto, Setsuo Harada, Yoshihiro Matsushita, Katsumi Itoh, Norikazu Tamura
Publikováno v:
Chemicalpharmaceutical bulletin. 39(5)
(S)-2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A (1)) is a novel amino acid antibiotic which shows a high affinity for glutamate receptors of the central nervous system. To improve the affinity for glutamate receptors, the stru